PMID- 34887960
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240404
IS  - 1880-4276 (Print)
IS  - 1883-2148 (Electronic)
IS  - 1880-4276 (Linking)
VI  - 37
IP  - 6
DP  - 2021 Dec
TI  - Increasing age and atrial arrhythmias are associated with increased 
      thromboembolic events in a young cohort of adults with repaired tetralogy of 
      Fallot.
PG  - 1546-1554
LID - 10.1002/joa3.12630 [doi]
AB  - BACKGROUND: Adults with repaired Tetralogy of Fallot (rTOF) comprise one of the 
      largest cohorts among adults with congenital heart disease (ACHD). These patients 
      have a higher burden of atrial arrhythmias (AA), leading to increased adverse 
      events, including stroke and transient ischemic attack (TIA). However, the data 
      on factors associated with stroke/TIA in rTOF are limited, and classic risk 
      factors may not apply. We studied event rates and associated factors for 
      thromboembolism in a rTOF cohort. METHODS: Retrospective cohort study of all 
      adult patients age >18 years with rTOF followed at a single ACHD tertiary care 
      center. AA of interest were atrial fibrillation (AF) and atrial flutter (AFL). 
      RESULTS: Data from 260 patients were identified, mean age 37.6 SD 13.3 years, 
      followed over 5108 patient-years (mean 16.6 SD 8.2 years). 43 patients had AF 
      and/or AFL, and 30 patients had thromboembolic events, of which 19 patients had 
      stroke/TIA. The event rate for any thromboembolism was 3.39 per 100 patient-years 
      follow-up in patients with AA, compared to 1.80 in patients without (P = .07). In 
      univariate analysis, older age and diabetes were associated with thromboembolic 
      events. In multivariate analysis, only older age was associated with 
      thromboembolic events. CONCLUSIONS: In our relatively young cohort of adults with 
      rTOF, there was a high prevalence of AA, associated with nearly double the rate 
      of thromboembolic events compared to patients without AA. Older age alone is 
      independently associated with thromboembolic events. Further studies into 
      assessment of silent AA are required, and routine assessments should be 
      considered at an earlier age.
CI  - (c) 2021 The Authors. Journal of Arrhythmia published by John Wiley & Sons 
      Australia, Ltd on behalf of Japanese Heart Rhythm Society.
FAU - Tsui, Clara
AU  - Tsui C
AUID- ORCID: 0000-0002-0606-385X
AD  - Department of Medicine University of British Columbia Vancouver BC Canada.
FAU - Wan, Darryl
AU  - Wan D
AD  - Department of Medicine University of British Columbia Vancouver BC Canada.
FAU - Grewal, Jasmine
AU  - Grewal J
AD  - Division of Cardiology Department of Medicine St. Paul's Hospital Vancouver BC 
      Canada.
FAU - Kiess, Marla
AU  - Kiess M
AD  - Division of Cardiology Department of Medicine St. Paul's Hospital Vancouver BC 
      Canada.
FAU - Barlow, Amanda
AU  - Barlow A
AD  - Division of Cardiology Department of Medicine St. Paul's Hospital Vancouver BC 
      Canada.
FAU - Human, Derek
AU  - Human D
AD  - Division of Cardiology Department of Medicine St. Paul's Hospital Vancouver BC 
      Canada.
FAU - Chakrabarti, Santabhanu
AU  - Chakrabarti S
AD  - Division of Cardiology Department of Medicine St. Paul's Hospital Vancouver BC 
      Canada.
LA  - eng
PT  - Journal Article
DEP - 20210912
PL  - Japan
TA  - J Arrhythm
JT  - Journal of arrhythmia
JID - 101263026
PMC - PMC8637093
OTO - NOTNLM
OT  - atrial arrhythmia
OT  - congenital heart disease
OT  - tetralogy of Fallot
OT  - thromboembolic events
EDAT- 2021/12/11 06:00
MHDA- 2021/12/11 06:01
PMCR- 2021/09/12
CRDT- 2021/12/10 06:42
PHST- 2021/02/21 00:00 [received]
PHST- 2021/08/04 00:00 [revised]
PHST- 2021/08/20 00:00 [accepted]
PHST- 2021/12/10 06:42 [entrez]
PHST- 2021/12/11 06:00 [pubmed]
PHST- 2021/12/11 06:01 [medline]
PHST- 2021/09/12 00:00 [pmc-release]
AID - JOA312630 [pii]
AID - 10.1002/joa3.12630 [doi]
PST - epublish
SO  - J Arrhythm. 2021 Sep 12;37(6):1546-1554. doi: 10.1002/joa3.12630. eCollection 
      2021 Dec.