PMID- 34888016
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211211
IS  - 1948-9358 (Print)
IS  - 1948-9358 (Electronic)
IS  - 1948-9358 (Linking)
VI  - 12
IP  - 11
DP  - 2021 Nov 15
TI  - Association between admission hemoglobin level and prognosis in patients with 
      type 2 diabetes mellitus.
PG  - 1917-1927
LID - 10.4239/wjd.v12.i11.1917 [doi]
AB  - BACKGROUND: Anaemia is common in patients with chronic kidney disease (CKD) and 
      is a major risk factor that contributes to mortality in such patients. Type 2 
      diabetes mellitus (T2DM) is one of the leading causes of CKD. The association 
      between admission hemoglobin levels and renal damage in patients with T2DM 
      remains unclear. AIM: To evaluate the relationship between admission hemoglobin 
      levels and prognosis in patients with T2DM. METHODS: We performed a retrospective 
      analysis of 265 consecutive patients presenting with T2DM between 2011 and 2015. 
      The composite endpoint was end-stage renal disease or a 50% reduction in the 
      estimated glomerular filtration rate. RESULTS: In multivariable-adjusted Cox 
      proportional hazards models (adjusting for demographic factors, traditional risk 
      factors, lipids), the adjusted hazard ratios (HRs) for the highest and middle 
      tertiles compared to the lowest tertile of hemoglobin were 0.82 (95%CI: 
      0.11-6.26, P = 0.8457) and 0.28 (95%CI: 0.09-0.85, P = 0.0246), respectively. 
      However, after further adjustment for glycaemia control, hemoglobin was 
      positively related to the risk of the composite endpoint (HR: 1.05, 95%CI: 
      0.14-8.09, P = 0.9602) when the highest tertile was compared to the lowest 
      tertile of hemoglobin. We found a U-shaped relationship between hemoglobin levels 
      and the composite endpoint. The curve tended to reach the lowest level at an 
      optimal hemoglobin level. CONCLUSION: Among patients with T2DM, a U-shaped 
      relationship was observed between hemoglobin levels and renal damage. A lower 
      admission hemoglobin level (hemoglobin < 13.3 g/dL) is an independent predictor 
      of renal damage.
CI  - (c)The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Song, Hai-Ying
AU  - Song HY
AD  - Department of Nephrology, The First Affiliated Hospital of Shenzhen University, 
      Shenzhen Second People's Hospital, Shenzhen 518035, Guangdong Province, China.
FAU - Wei, Cui-Mei
AU  - Wei CM
AD  - Department of Nephrology, The First Affiliated Hospital of Shenzhen University, 
      Shenzhen Second People's Hospital, Shenzhen 518035, Guangdong Province, China.
FAU - Zhou, Wen-Xiong
AU  - Zhou WX
AD  - Department of Nephrology, The First Affiliated Hospital of Shenzhen University, 
      Shenzhen Second People's Hospital, Shenzhen 518035, Guangdong Province, China.
FAU - Hu, Hao-Fei
AU  - Hu HF
AD  - Department of Nephrology, The First Affiliated Hospital of Shenzhen University, 
      Shenzhen Second People's Hospital, Shenzhen 518035, Guangdong Province, China.
FAU - Wan, Qi-Jun
AU  - Wan QJ
AD  - Department of Nephrology, The First Affiliated Hospital of Shenzhen University, 
      Shenzhen Second People's Hospital, Shenzhen 518035, Guangdong Province, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Diabetes
JT  - World journal of diabetes
JID - 101547524
PMC - PMC8613662
OTO - NOTNLM
OT  - Hemoglobin
OT  - Prognosis
OT  - Renal damage
OT  - Type 2 diabetes mellitus
COIS- Conflict-of-interest statement: The authors declare that they have no conflicts 
      of interest to disclose.
EDAT- 2021/12/11 06:00
MHDA- 2021/12/11 06:01
PMCR- 2021/11/15
CRDT- 2021/12/10 06:43
PHST- 2021/02/05 00:00 [received]
PHST- 2021/04/18 00:00 [revised]
PHST- 2021/10/11 00:00 [accepted]
PHST- 2021/12/10 06:43 [entrez]
PHST- 2021/12/11 06:00 [pubmed]
PHST- 2021/12/11 06:01 [medline]
PHST- 2021/11/15 00:00 [pmc-release]
AID - 10.4239/wjd.v12.i11.1917 [doi]
PST - ppublish
SO  - World J Diabetes. 2021 Nov 15;12(11):1917-1927. doi: 10.4239/wjd.v12.i11.1917.