PMID- 34888362
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211211
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 8
DP  - 2021
TI  - Incidence- and In-hospital Mortality-Related Risk Factors of Acute Kidney Injury 
      Requiring Continuous Renal Replacement Therapy in Patients Undergoing Surgery for 
      Acute Type a Aortic Dissection.
PG  - 749592
LID - 10.3389/fcvm.2021.749592 [doi]
LID - 749592
AB  - Background: Few studies on the risk factors for postoperative continuous renal 
      replacement therapy (CRRT) in a homogeneous population of patients with acute 
      type A aortic dissection (AAAD). This retrospective analysis aimed to investigate 
      the risk factors for CRRT and in-hospital mortality in the patients undergoing 
      AAAD surgery and to discuss the perioperative comorbidities and short-term 
      outcomes. Methods: The study collected electronic medical records and laboratory 
      data from 432 patients undergoing surgery for AAAD between March 2009 and June 
      2021. All the patients were divided into CRRT and non-CRRT groups; those in the 
      CRRT group were divided into the survivor and non-survivor groups. The 
      univariable and multivariable analyses were used to identify the independent risk 
      factors for CRRT and in-hospital mortality. Results: The proportion of requiring 
      CRRT and in-hospital mortality in the patients with CRRT was 14.6 and 46.0%, 
      respectively. Baseline serum creatinine (SCr) [odds ratio (OR), 1.006], cystatin 
      C (OR, 1.438), lung infection (OR, 2.292), second thoracotomy (OR, 5.185), 
      diabetes mellitus (OR, 6.868), AKI stage 2-3 (OR, 22.901) were the independent 
      risk factors for receiving CRRT. In-hospital mortality in the CRRT group (46%) 
      was 4.6 times higher than in the non-CRRT group (10%). In the non-survivor (n = 
      29) and survivor (n = 34) groups, New York Heart Association (NYHA) class III-IV 
      (OR, 10.272, P = 0.019), lactic acidosis (OR, 10.224, P = 0.019) were the 
      independent risk factors for in-hospital mortality in patients receiving CRRT. 
      Conclusion: There was a high rate of CRRT requirement and high in-hospital 
      mortality after AAAD surgery. The risk factors for CRRT and in-hospital mortality 
      in the patients undergoing AAAD surgery were determined to help identify the 
      high-risk patients and make appropriate clinical decisions. Further randomized 
      controlled studies are urgently needed to establish the risk factors for CRRT and 
      in-hospital mortality.
CI  - Copyright (c) 2021 Chen, Zhou, Fang, Yang, Wang, Wang, Li, Zhu, Ji and Yang.
FAU - Chen, Xuelian
AU  - Chen X
AD  - Division of Nephrology, Department of Medicine, West China Hospital of Sichuan 
      University, Chengdu, China.
FAU - Zhou, Jiaojiao
AU  - Zhou J
AD  - Division of Ultrasound, West China Hospital, Sichuan University, Chengdu, China.
FAU - Fang, Miao
AU  - Fang M
AD  - Department of Orthopedics, Second People's Hospital of Chengdu, Chengdu, China.
FAU - Yang, Jia
AU  - Yang J
AD  - Division of Nephrology, Department of Medicine, West China Hospital of Sichuan 
      University, Chengdu, China.
FAU - Wang, Xin
AU  - Wang X
AD  - Department of Pediatric Nephrology, West China Second University Hospital, 
      Sichuan University, Chengdu, China.
FAU - Wang, Siwen
AU  - Wang S
AD  - Division of Nephrology, Department of Medicine, West China Hospital of Sichuan 
      University, Chengdu, China.
FAU - Li, Linji
AU  - Li L
AD  - Department of Anesthesiology, West China Hospital, Sichuan University, The 
      Research Units of West China (2018RU012), Chinese Academy of Medical Sciences, 
      Chengdu, China.
FAU - Zhu, Tao
AU  - Zhu T
AD  - Department of Anesthesiology, West China Hospital, Sichuan University, The 
      Research Units of West China (2018RU012), Chinese Academy of Medical Sciences, 
      Chengdu, China.
FAU - Ji, Ling
AU  - Ji L
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 
      China.
FAU - Yang, Lichuan
AU  - Yang L
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20211123
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC8650701
OTO - NOTNLM
OT  - CRRT
OT  - acute kidney injury
OT  - acute type A aortic dissection
OT  - continuous renal replacement therapy
OT  - risk factors
OT  - surgery
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/12/11 06:00
MHDA- 2021/12/11 06:01
PMCR- 2021/01/01
CRDT- 2021/12/10 06:47
PHST- 2021/07/29 00:00 [received]
PHST- 2021/09/27 00:00 [accepted]
PHST- 2021/12/10 06:47 [entrez]
PHST- 2021/12/11 06:00 [pubmed]
PHST- 2021/12/11 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2021.749592 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2021 Nov 23;8:749592. doi: 10.3389/fcvm.2021.749592. 
      eCollection 2021.