PMID- 34888686
OWN - NLM
STAT- MEDLINE
DCOM- 20220316
LR  - 20220316
IS  - 2042-7158 (Electronic)
IS  - 0022-3573 (Linking)
VI  - 74
IP  - 2
DP  - 2022 Feb 1
TI  - Neuroprotective effects of synthetic borneol and natural borneol based on the 
      neurovascular unit against cerebral ischaemic injury.
PG  - 236-249
LID - 10.1093/jpp/rgab167 [doi]
AB  - OBJECTIVES: Natural borneol and synthetic borneol were commonly used to treat 
      ischaemic stroke in clinical practice. This study evaluated their different 
      neuroprotective effects on the remodelling and repair of the neurovascular unit 
      (NVU) after cerebral ischaemia. METHODS: We evaluated the different effects of 
      borneol through neurological test and staining methods in cerebral ischaemia 
      injury. Western blot, immunohistochemistry and transmission electron microscopy 
      were used to evaluate the reparative effects of borneol on NVU. KEY FINDINGS: The 
      prevention and treatment of borneol could prolong recovery time, reduce body 
      temperature and cerebral infarction rate and improve pathological conditions. 
      Further investigations revealed that borneol could inhibit the expression of 
      DII4, Hes1, Hes5 and p65 and increase the Nissl body number and microvessel 
      density. They also inhibited the activation of the microglia. It was also 
      observed through an ultramicroelectron microscope that the structural stability 
      of the NVU has also been repaired. Moreover, natural borneol shows better results 
      in most indicators when compared with synthetic borneol. CONCLUSIONS: Natural 
      borneol showed a stronger effectiveness and had better regulation and 
      neuroprotection on the NVU when compared with synthetic borneol, indicating that 
      it may be better to use natural borneol in the prescription of Chinese patent 
      medicine in clinical practice.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the Royal 
      Pharmaceutical Society. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Xie, Qian
AU  - Xie Q
AD  - State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest 
      China, Chengdu, P.R. China.
AD  - School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 
      P.R. China.
FAU - Li, Jinxiu
AU  - Li J
AD  - State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest 
      China, Chengdu, P.R. China.
AD  - School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 
      P.R. China.
FAU - Dong, Taiwei
AU  - Dong T
AD  - College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, P.R. 
      China.
FAU - Yuan, Jianmei
AU  - Yuan J
AD  - State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest 
      China, Chengdu, P.R. China.
AD  - School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 
      P.R. China.
FAU - Lu, Danni
AU  - Lu D
AD  - State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest 
      China, Chengdu, P.R. China.
AD  - School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 
      P.R. China.
FAU - Ma, Rong
AU  - Ma R
AD  - State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest 
      China, Chengdu, P.R. China.
AD  - School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 
      P.R. China.
FAU - Li, Hongyan
AU  - Li H
AD  - State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest 
      China, Chengdu, P.R. China.
AD  - School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 
      P.R. China.
FAU - Li, Yong
AU  - Li Y
AD  - State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest 
      China, Chengdu, P.R. China.
AD  - School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 
      P.R. China.
FAU - Ren, Mihong
AU  - Ren M
AD  - State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest 
      China, Chengdu, P.R. China.
AD  - School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 
      P.R. China.
FAU - Chen, Hai
AU  - Chen H
AD  - State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest 
      China, Chengdu, P.R. China.
AD  - School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 
      P.R. China.
FAU - Wang, Jian
AU  - Wang J
AUID- ORCID: 0000-0002-5773-2486
AD  - State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest 
      China, Chengdu, P.R. China.
AD  - School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 
      P.R. China.
LA  - eng
GR  - 81873023/National Natural Science Foundation of China/
GR  - CXTD2018004/Chengdu University of Traditional Chinese Medicine/
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - J Pharm Pharmacol
JT  - The Journal of pharmacy and pharmacology
JID - 0376363
RN  - 0 (Camphanes)
RN  - 0 (Neuroprotective Agents)
RN  - L88RA8N5EG (isoborneol)
SB  - IM
MH  - Animals
MH  - Body Temperature/drug effects
MH  - Brain Ischemia/*drug therapy/pathology
MH  - Camphanes/chemistry/*pharmacology
MH  - Disease Models, Animal
MH  - Male
MH  - Microglia/drug effects
MH  - Microscopy, Electron, Transmission
MH  - Neuroprotective Agents/chemistry/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Notch pathway
OT  - middle cerebral artery occlusion model
OT  - natural borneol
OT  - neuroprotection
OT  - neurovascular units
OT  - synthetic borneol
EDAT- 2021/12/11 06:00
MHDA- 2022/03/17 06:00
CRDT- 2021/12/10 06:56
PHST- 2021/05/05 00:00 [received]
PHST- 2021/11/05 00:00 [accepted]
PHST- 2021/12/11 06:00 [pubmed]
PHST- 2022/03/17 06:00 [medline]
PHST- 2021/12/10 06:56 [entrez]
AID - 6457965 [pii]
AID - 10.1093/jpp/rgab167 [doi]
PST - ppublish
SO  - J Pharm Pharmacol. 2022 Feb 1;74(2):236-249. doi: 10.1093/jpp/rgab167.