PMID- 3489051
OWN - NLM
STAT- MEDLINE
DCOM- 19861010
LR  - 20190723
IS  - 0022-202X (Print)
IS  - 0022-202X (Linking)
VI  - 86
IP  - 3
DP  - 1986 Mar
TI  - Circulating T- and B-cell abnormalities in cutaneous lupus erythematosus.
PG  - 235-9
AB  - Seven patients with subacute cutaneous lupus erythematosus (SCLE), 11 patients 
      with discoid lupus erythematosus (DLE), and 17 age-, sex-, and race-matched 
      controls were examined for the number of circulating peripheral blood T and B 
      cells, immunoglobulin (Ig) synthesizing cells, and Ig secreting cells. A 
      significant alteration in T-cell subsets was detected only in SCLE patients who 
      manifested a decreased number of OKT8 cells. Circulating B cells were 
      significantly increased only in the SCLE patients. The percentage of Ig 
      synthesizing and secreting cells was significantly increased in both the DLE and 
      the SCLE groups. The somewhat unexpected increase in Ig synthesizing and 
      secreting cells in the DLE patients could not be accounted for by antimalarial 
      treatment or the concurrence of the HLA-DR3 phenotype. There was, however, a weak 
      but significant correlation between the degree of B-cell activation in the DLE 
      patients and the number of American Rheumatism Association criteria for the 
      classification of systemic lupus erythematosus (SLE) possessed by these patients. 
      These data demonstrate that abnormalities in B-cell function similar to those 
      seen in SLE can also be found in a group of lupus erythematosus patients whose 
      clinical disease expression is limited predominantly to the skin.
FAU - Kind, P
AU  - Kind P
FAU - Lipsky, P E
AU  - Lipsky PE
FAU - Sontheimer, R D
AU  - Sontheimer RD
LA  - eng
GR  - AI17363/AI/NIAID NIH HHS/United States
GR  - AM09989/AM/NIADDK NIH HHS/United States
GR  - AM19101/AM/NIADDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
RN  - 0 (HLA-DR3 Antigen)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Immunoglobulins)
SB  - IM
MH  - B-Lymphocytes/*immunology
MH  - Female
MH  - HLA-DR3 Antigen
MH  - Histocompatibility Antigens Class II/analysis
MH  - Humans
MH  - Immunoglobulins/biosynthesis
MH  - Lupus Erythematosus, Discoid/*immunology
MH  - Lymphocyte Activation
MH  - Male
MH  - T-Lymphocytes/*immunology
EDAT- 1986/03/01 00:00
MHDA- 1986/03/01 00:01
CRDT- 1986/03/01 00:00
PHST- 1986/03/01 00:00 [pubmed]
PHST- 1986/03/01 00:01 [medline]
PHST- 1986/03/01 00:00 [entrez]
AID - S0022-202X(86)90933-4 [pii]
AID - 10.1111/1523-1747.ep12285191 [doi]
PST - ppublish
SO  - J Invest Dermatol. 1986 Mar;86(3):235-9. doi: 10.1111/1523-1747.ep12285191.