PMID- 34891890
OWN - NLM
STAT- MEDLINE
DCOM- 20211230
LR  - 20211230
IS  - 2694-0604 (Electronic)
IS  - 2375-7477 (Linking)
VI  - 2021
DP  - 2021 Nov
TI  - Multiframe Evolving Dynamic Functional Network Connectivity Motifs (Evodfncs) 
      from Continuity-Preserving Planar Embedding.
PG  - 3066-3069
LID - 10.1109/EMBC46164.2021.9630532 [doi]
AB  - The study of brain network connectivity as a time-varying property began 
      relatively recently and to date has remained primarily concerned with capturing a 
      handful of discrete static states that characterize connectivity as measured on a 
      timescale shorter than that of the full scan. Capturing group- level 
      representations of temporally evolving patterns of connectivity is a challenging 
      and important next step in fully leveraging the information available in large 
      resting state functional magnetic resonance imaging (rs-fMRI) studies. We 
      introduce a flexible, extensible data-driven framework for the identification of 
      group-level multiframe (movie-style) dynamic functional network connectivity 
      (dFNC) states. Our approach employs uniform manifold approximation and embedding 
      (UMAP) to produce a planar embedding of the high-dimensional whole-brain 
      connectivity dynamics that preserves important features, such as trajectory 
      continuity, characterizing dynamics in the native high dimensional state space. 
      The method is validated in application to a large rs- fMRI study of schizophrenia 
      where it extracts naturalistic fluidly-varying connectivity motifs that differ 
      between schizophrenia patients (SZs) and healthy controls (HC).Functional 
      Magnetic Resonance Imaging, Functional Network Connectivity, Dynamic Functional 
      Network Connectivity, Schizophrenia.
FAU - Miller, Robyn L
AU  - Miller RL
FAU - Vergara, Victor M
AU  - Vergara VM
FAU - Calhoun, Vince D
AU  - Calhoun VD
LA  - eng
GR  - R01 EB006841/EB/NIBIB NIH HHS/United States
GR  - R01 MH118695/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Annu Int Conf IEEE Eng Med Biol Soc
JT  - Annual International Conference of the IEEE Engineering in Medicine and Biology 
      Society. IEEE Engineering in Medicine and Biology Society. Annual International 
      Conference
JID - 101763872
SB  - IM
MH  - Brain/diagnostic imaging
MH  - *Brain Mapping
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - *Schizophrenia
EDAT- 2021/12/12 06:00
MHDA- 2021/12/31 06:00
CRDT- 2021/12/11 01:02
PHST- 2021/12/11 01:02 [entrez]
PHST- 2021/12/12 06:00 [pubmed]
PHST- 2021/12/31 06:00 [medline]
AID - 10.1109/EMBC46164.2021.9630532 [doi]
PST - ppublish
SO  - Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:3066-3069. doi: 
      10.1109/EMBC46164.2021.9630532.