PMID- 34891919
OWN - NLM
STAT- MEDLINE
DCOM- 20211230
LR  - 20211230
IS  - 2694-0604 (Electronic)
IS  - 2375-7477 (Linking)
VI  - 2021
DP  - 2021 Nov
TI  - A Method for Integrative Analysis of Local and Global Brain Dynamics.
PG  - 3189-3192
LID - 10.1109/EMBC46164.2021.9630444 [doi]
AB  - The most common pipelines for studying time-varying network connectivity in 
      resting state functional magnetic resonance imaging (rs-fMRI) operate at the 
      whole brain level, capturing a small discrete set of "states" that best represent 
      time-resolved joint measures of connectivity over all network pairs in the brain. 
      This whole-brain hidden Markov model (HMM) approach "uniformizes" the dynamics 
      over what is typically more than 1000 pairs of networks, forcing each 
      time-resolved high-dimensional observation into its best-matched high-dimensional 
      state. While straightforward and convenient, this HMM simplification obscures 
      functional and temporal nonstationarities that could reveal systematic, 
      informative features of resting state brain dynamics at a more granular scale. We 
      introduce a framework for studying functionally localized dynamics that 
      intrinsically embeds them within a whole-brain HMM frame of reference. The 
      approach is validated in a large rs-fMRI schizophrenia study where it identifies 
      group differences in localized patterns of entropy and dynamics that help explain 
      consistently observed differences between schizophrenia patients and controls in 
      occupancy of whole-brain dFNC states more mechanistically.
FAU - Miller, Robyn L
AU  - Miller RL
FAU - Vergara, Victor M
AU  - Vergara VM
FAU - Calhoun, Vince D
AU  - Calhoun VD
LA  - eng
GR  - R01 MH123610/MH/NIMH NIH HHS/United States
GR  - R01 MH118695/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Annu Int Conf IEEE Eng Med Biol Soc
JT  - Annual International Conference of the IEEE Engineering in Medicine and Biology 
      Society. IEEE Engineering in Medicine and Biology Society. Annual International 
      Conference
JID - 101763872
SB  - IM
MH  - Brain/diagnostic imaging
MH  - *Brain Mapping
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Research Design
MH  - *Schizophrenia/diagnostic imaging
EDAT- 2021/12/12 06:00
MHDA- 2021/12/31 06:00
CRDT- 2021/12/11 01:03
PHST- 2021/12/11 01:03 [entrez]
PHST- 2021/12/12 06:00 [pubmed]
PHST- 2021/12/31 06:00 [medline]
AID - 10.1109/EMBC46164.2021.9630444 [doi]
PST - ppublish
SO  - Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:3189-3192. doi: 
      10.1109/EMBC46164.2021.9630444.