PMID- 34893049
OWN - NLM
STAT- MEDLINE
DCOM- 20211214
LR  - 20211214
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 21
IP  - 1
DP  - 2021 Dec 10
TI  - RPE disruption and hyper-transmission are early signs of secondary CNV with 
      punctate inner choroidopathy in structure-OCT.
PG  - 427
LID - 10.1186/s12886-021-02197-7 [doi]
LID - 427
AB  - PURPOSE: To study whether retinal pigment epithelium (RPE) disruption and 
      choroidal hyper-transmission on spectral-domain optical coherence tomography 
      (SD-OCT) are signs of inflammatory neovascularization (CNV) in punctate inner 
      choroidopathy (PIC). METHODS: This is a prospective cohort study. Seventeen 
      patients (18 eyes) were diagnosed as PIC without CNV at baseline. Changes of 
      morphological characteristics including choroidal hyper-transmission, 
      hypo-transmission, RPE disruption, and ellipsoid zone (EZ) damage on SD-OCT were 
      observed and recorded at baseline, 4, 8 and 12 weeks, respectively. The 
      occurrence of CNV was detected by OCTA at each visit. Fisher's exact test was 
      used to compare the relationship with each morphological sign and evaluate the 
      predictable capability of secondary CNV in PIC (PIC+CNV) based on the structure 
      changes on OCT. RESULTS: Among the 18 eyes, a total of 5 eyes (27.8%) developed 
      PIC+CNV subsequently within 4 weeks follow-up. At 4, 8 and 12 weeks of follow-up, 
      RPE disruption and choroidal hyper-transmission were found in all 5 PIC+CNV eyes. 
      The incidence of RPE disruption was significant higher in PIC+CNV eyes compared 
      with PIC eyes (P=0.001). PIC eyes with hyper-transmission had a higher risk for 
      developing CNV compared with those without hyper-transmission (P=1.17x10(-3)). 2 
      out of 5 PIC+CNV eyes had a choroidal hypo-transmission component adjacent to 
      hyper-transmission zone at 4 weeks of follow-up, and hypo-transmission could be 
      observed in all 5 PIC+CNV eyes at 8 weeks of follow-up. The incidence of 
      choroidal hypo-transmission was significant higher in PIC+CNV eyes than PIC eyes 
      after 8 weeks. EZ damage began to recover at 4 weeks of follow-up and had no 
      significant difference in the PIC eyes and PIC+CNV eyes (P=0.150, 0.196, 0.353). 
      CONCLUSION: The presence of choroidal hyper-transmission and RPE disruption on 
      SD-OCT is associated with the PIC+CNV. SD-OCT imaging facilitates the 
      differentiation and track of the progression of inflammatory lesions and 
      secondary CNV in PIC.
CI  - (c) 2021. The Author(s).
FAU - Chen, Yanru
AU  - Chen Y
AD  - Xiamen University affiliated Xiamen Eye Center, Wutong West Road 989, Hu Li 
      District, Xiamen, 361100, Fujian, China.
FAU - Chen, Qian
AU  - Chen Q
AD  - Eye Institute of Xiamen University; School of Medicine, Xiamen University, 
      Xiamen, 361102, Fujian, China.
FAU - Li, Xiaoxin
AU  - Li X
AD  - Xiamen University affiliated Xiamen Eye Center, Wutong West Road 989, Hu Li 
      District, Xiamen, 361100, Fujian, China. dr_lixiaoxin@163.com.
FAU - Li, Minghan
AU  - Li M
AD  - Xiamen University affiliated Xiamen Eye Center, Wutong West Road 989, Hu Li 
      District, Xiamen, 361100, Fujian, China. 740118340@qq.com.
LA  - eng
PT  - Journal Article
DEP - 20211210
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
SB  - IM
MH  - Choroid
MH  - Humans
MH  - Prospective Studies
MH  - *Retinal Pigment Epithelium
MH  - Tomography, Optical Coherence
MH  - *White Dot Syndromes
PMC - PMC8662850
OTO - NOTNLM
OT  - Choroidal neovascularization
OT  - Optical coherence tomography
OT  - Punctuate inner choroidopathy
OT  - Transmission
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2021/12/12 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/12/10
CRDT- 2021/12/11 05:23
PHST- 2021/07/27 00:00 [received]
PHST- 2021/11/29 00:00 [accepted]
PHST- 2021/12/11 05:23 [entrez]
PHST- 2021/12/12 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/12/10 00:00 [pmc-release]
AID - 10.1186/s12886-021-02197-7 [pii]
AID - 2197 [pii]
AID - 10.1186/s12886-021-02197-7 [doi]
PST - epublish
SO  - BMC Ophthalmol. 2021 Dec 10;21(1):427. doi: 10.1186/s12886-021-02197-7.