PMID- 34894090
OWN - NLM
STAT- MEDLINE
DCOM- 20220411
LR  - 20220411
IS  - 1942-7611 (Electronic)
IS  - 1942-7603 (Linking)
VI  - 14
IP  - 4
DP  - 2022 Apr
TI  - Recent applications of phosphodiesterase (PDE5) inhibition assays for detecting 
      adulterated sexual enhancement products.
PG  - 757-761
LID - 10.1002/dta.3209 [doi]
AB  - Consumer products marketed for sexual enhancement are frequently adulterated with 
      erectile dysfunction (ED) drugs and analogs; consuming these undisclosed 
      adulterants can pose significant health hazards. Although ED drugs/analogs have 
      unpredictable and diverse structures that pose challenges for detecting them, 
      they all share the ability to inhibit phosphodiesterase-5 (PDE5) activity, a 
      pharmacological mechanism responsible for their effects. Consequently, several 
      PDE5 inhibition assays have been recently applied as screening methods to detect 
      ED drug/analogs in products. Here, the successes and challenges are highlighted 
      for screening sexual enhancement products by PDE5 inhibition assays.
CI  - Published 2021. This article is a U.S. Government work and is in the public 
      domain in the USA.
FAU - Santillo, Michael F
AU  - Santillo MF
AUID- ORCID: 0000-0001-8087-5859
AD  - Division of Toxicology, Office of Applied Research and Safety Assessment, Center 
      for Food Safety and Applied Nutrition, U.S. Food and Drug Administration (FDA), 
      Laurel, Maryland, USA.
LA  - eng
PT  - Journal Article
DEP - 20211215
PL  - England
TA  - Drug Test Anal
JT  - Drug testing and analysis
JID - 101483449
RN  - 0 (Phosphodiesterase 5 Inhibitors)
RN  - EC 3.1.4.- (Phosphoric Diester Hydrolases)
SB  - IM
MH  - *Erectile Dysfunction/drug therapy
MH  - Humans
MH  - Male
MH  - *Phosphodiesterase 5 Inhibitors/pharmacology
MH  - Phosphoric Diester Hydrolases
EDAT- 2021/12/12 06:00
MHDA- 2022/04/12 06:00
CRDT- 2021/12/11 06:26
PHST- 2021/11/09 00:00 [revised]
PHST- 2021/10/05 00:00 [received]
PHST- 2021/11/19 00:00 [accepted]
PHST- 2021/12/12 06:00 [pubmed]
PHST- 2022/04/12 06:00 [medline]
PHST- 2021/12/11 06:26 [entrez]
AID - 10.1002/dta.3209 [doi]
PST - ppublish
SO  - Drug Test Anal. 2022 Apr;14(4):757-761. doi: 10.1002/dta.3209. Epub 2021 Dec 15.