PMID- 34894109
OWN - NLM
STAT- MEDLINE
DCOM- 20220418
LR  - 20220418
IS  - 1099-0496 (Electronic)
IS  - 1099-0496 (Linking)
VI  - 57
IP  - 3
DP  - 2022 Mar
TI  - Outdoor pollen concentration is not associated with exercise-induced 
      bronchoconstriction in children.
PG  - 695-701
LID - 10.1002/ppul.25782 [doi]
AB  - BACKGROUND: Free running exercise test outdoors is an important method to 
      diagnose asthma in children. However, the extent of how much exposure to pollens 
      of outdoor air affects the results of the test is not known. METHODS: We analyzed 
      all reliable exercise challenge tests with impulse oscillometry in children 
      (n = 799) between January 2012 and December 2014 in Tampere University Hospital. 
      Pollen concentrations at the time of the test were collected from the register of 
      Biodiversity Unit of the University of Turku. We compared the frequency of 
      exercise-induced bronchoconstriction and pollen concentrations. RESULTS: The 
      analyses were restricted to birch and alder pollen as high counts of grass and 
      mugwort pollen were so infrequent. The relative change in resistance at 5 Hz 
      after exercise or the frequency of exercise-induced bronchoconstriction were not 
      related to alder or birch pollen concentrations over 10 grains/m(3) 
      (p = 0.125-0.398). In logistic regression analysis comparing the effects of alder 
      or birch pollen concentrations, immunoglobulin E (IgE)-mediated alder or birch 
      allergy and absolute humidity over 10 g/m(3) only absolute humidity was 
      independently associated with change in airway resistance (odds ratio [OR]: 0.32, 
      confidence interval [CI]: 0.13-0.67, p: 0.006). CONCLUSIONS: In our large 
      clinical sample, outdoor air pollen concentration was not associated with the 
      probability of exercise-induced bronchoconstriction in free running test in 
      children while low absolute humidity was the best predictor of airway 
      obstruction.
CI  - (c) 2021 Wiley Periodicals LLC.
FAU - Tikkakoski, Anna P
AU  - Tikkakoski AP
AD  - Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
FAU - Karjalainen, Jussi
AU  - Karjalainen J
AD  - Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
AD  - Allergy Centre, Tampere University Hospital, Tampere, Finland.
FAU - Sipila, Kalle
AU  - Sipila K
AD  - Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
FAU - Kivisto, Juho E
AU  - Kivisto JE
AD  - Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
AD  - Allergy Centre, Tampere University Hospital, Tampere, Finland.
FAU - Kahonen, Mika
AU  - Kahonen M
AD  - Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
AD  - Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
FAU - Lehtimaki, Lauri
AU  - Lehtimaki L
AD  - Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
AD  - Allergy Centre, Tampere University Hospital, Tampere, Finland.
FAU - Tikkakoski, Antti
AU  - Tikkakoski A
AD  - Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211221
PL  - United States
TA  - Pediatr Pulmonol
JT  - Pediatric pulmonology
JID - 8510590
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens
MH  - *Asthma/diagnosis/etiology
MH  - Bronchoconstriction
MH  - Child
MH  - Humans
MH  - *Hypersensitivity
MH  - Immunoglobulin E
MH  - Pollen
OTO - NOTNLM
OT  - asthma
OT  - exercise test
OT  - exercise-induced asthma
OT  - pollen
OT  - pulmonary function tests
EDAT- 2021/12/12 06:00
MHDA- 2022/04/19 06:00
CRDT- 2021/12/11 06:27
PHST- 2021/11/07 00:00 [revised]
PHST- 2021/03/23 00:00 [received]
PHST- 2021/12/01 00:00 [accepted]
PHST- 2021/12/12 06:00 [pubmed]
PHST- 2022/04/19 06:00 [medline]
PHST- 2021/12/11 06:27 [entrez]
AID - 10.1002/ppul.25782 [doi]
PST - ppublish
SO  - Pediatr Pulmonol. 2022 Mar;57(3):695-701. doi: 10.1002/ppul.25782. Epub 2021 Dec 
      21.