PMID- 34895017
OWN - NLM
STAT- MEDLINE
DCOM- 20220608
LR  - 20220727
IS  - 1744-5094 (Electronic)
IS  - 1381-6810 (Linking)
VI  - 43
IP  - 3
DP  - 2022 Jun
TI  - Polymorphism analysis of ADIPOQ gene in Greek patients with diabetic retinopathy.
PG  - 326-331
LID - 10.1080/13816810.2021.2015787 [doi]
AB  - BACKGROUND: Several genetic polymorphisms have been identified as risk factors 
      for diabetic retinopathy (DR) onset. The purpose of our study was to determine 
      whether ADIPOQ rs1501299 and rs2241766 gene polymorphisms are associated with DR 
      in a cohort of Greek diabetic patients. MATERIALS AND METHODS: 218 patients with 
      type-2 diabetes mellitus (T2DM) were included in the study; 109 suffered from DR 
      and 109 not. All the participants underwent a complete ophthalmological 
      examination, while clinical and demographic data were assessed. Furthermore, they 
      were genotyped for G276T (rs1501299) and T45G (rs2241766) single nucleotide 
      polymorphisms of ADIPOQ gene. RESULTS: Between the studied groups, no significant 
      differences were detected regarding the demographic and clinical data (p > .05 
      for all), except for hemoglobin A1c levels and frequency of insulin treatment 
      (higher in DR patients). We detected that the frequency of rs1501299 GT genotype 
      was significantly elevated in DR patients (53% vs. 34%, p = .004) and was 
      associated with a higher risk of developing retinopathy (OR 2.31, 95% CI 
      1.30-4.11). Furthermore, we demonstrated that the rs1501299 GT genotype was 
      significantly and independently associated with increased odds for DR development 
      in diabetic subjects (OR 2.68, 95% CI 1.38-5.21, p = .004), regardless of the 
      impact of other known risk factors. CONCLUSIONS: We documented that rs1501299 GT 
      genotype could be recognized as an independent risk factor of retinopathy in T2DM 
      Greek patients, while no role for rs2241766 polymorphism was identified. Further 
      research in different ethnic groups will clarify the exact association of these 
      polymorphisms with the risk of DR development.
FAU - Gouliopoulos, Nikolaos
AU  - Gouliopoulos N
AUID- ORCID: 0000-0002-4154-1597
AD  - 2nd Department of Ophthalmology, University of Athens Medical School, Athens, 
      Greece.
AD  - 1st Department of Ophthalmology, University of Athens Medical School, Athens, 
      Greece.
FAU - Siasos, Gerasimos
AU  - Siasos G
AD  - 1st Department of Cardiology, University of Athens Medical School, Athens, 
      Greece.
FAU - Bouratzis, Nikolaos
AU  - Bouratzis N
AD  - 2 Department of Ophthalmology, University of Athens Medical School, Athens, 
      Greece.
FAU - Oikonomou, Evangelos
AU  - Oikonomou E
AD  - 1 Department of Cardiology, University of Athens Medical School, Athens, Greece.
FAU - Kollia, Christina
AU  - Kollia C
AD  - 1 Department of Cardiology, University of Athens Medical School, Athens, Greece.
FAU - Konsola, Theodosia
AU  - Konsola T
AD  - 1 Department of Cardiology, University of Athens Medical School, Athens, Greece.
FAU - Oikonomou, Dimitra
AU  - Oikonomou D
AD  - 2 Department of Ophthalmology, University of Athens Medical School, Athens, 
      Greece.
FAU - Rouvas, Alexandros
AU  - Rouvas A
AD  - 2 Department of Ophthalmology, University of Athens Medical School, Athens, 
      Greece.
FAU - Kassi, Eva
AU  - Kassi E
AD  - 1st Department of Propaedeutic and Internal Medicine, Division of Diabetes, 
      University of Athens Medical School, Athens, Greece.
FAU - Tousoulis, Dimitrios
AU  - Tousoulis D
AD  - 1 Department of Cardiology, University of Athens Medical School, Athens, Greece.
FAU - Moschos, Marilita M
AU  - Moschos MM
AD  - 1 Department of Ophthalmology, University of Athens Medical School, Athens, 
      Greece.
LA  - eng
PT  - Journal Article
DEP - 20211213
PL  - England
TA  - Ophthalmic Genet
JT  - Ophthalmic genetics
JID - 9436057
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
SB  - IM
MH  - *Adiponectin/genetics
MH  - Case-Control Studies
MH  - *Diabetes Mellitus, Type 2/complications/genetics
MH  - *Diabetic Retinopathy/complications/genetics
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Greece/epidemiology
MH  - Humans
MH  - Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - Diabetic retinopathy
OT  - adiponectin
OT  - gene polymorphisms
OT  - rs1501299
OT  - rs2241766
EDAT- 2021/12/14 06:00
MHDA- 2022/06/09 06:00
CRDT- 2021/12/13 11:29
PHST- 2021/12/14 06:00 [pubmed]
PHST- 2022/06/09 06:00 [medline]
PHST- 2021/12/13 11:29 [entrez]
AID - 10.1080/13816810.2021.2015787 [doi]
PST - ppublish
SO  - Ophthalmic Genet. 2022 Jun;43(3):326-331. doi: 10.1080/13816810.2021.2015787. 
      Epub 2021 Dec 13.