PMID- 34895639
OWN - NLM
STAT- MEDLINE
DCOM- 20211214
LR  - 20211214
IS  - 1740-6749 (Electronic)
IS  - 1740-6749 (Linking)
VI  - 38
DP  - 2020 Dec
TI  - Synthetic carbohydrate-based cell wall components from Staphylococcus aureus.
PG  - 35-43
LID - S1740-6749(21)00005-6 [pii]
LID - 10.1016/j.ddtec.2021.01.003 [doi]
AB  - Glycopolymers are found surrounding the outer layer of many bacterial species. 
      The first uses as immunogenic component in vaccines are reported since the 
      beginning of the XX century, but it is only in the last decades that 
      glycoconjugate based vaccines have been effectively applied for controlling and 
      preventing several infectious diseases, such as H. influenzae type b (Hib), N. 
      meningitidis, S. pneumoniae or group B Streptococcus. Methicillin resistant S. 
      aureus (MRSA) strains has been appointed by the WHO as one of those pathogens, 
      for which new treatments are urgently needed. Herein we present an overview of 
      the carbohydrate-based cell wall polymers associated with different S. aureus 
      strains and the related affords to deliver well-defined fragments through 
      synthetic chemistry.
CI  - Copyright (c) 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.
FAU - Berni, Francesca
AU  - Berni F
AD  - Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, 
      The Netherlands.
FAU - Enotarpi, Jacopo
AU  - Enotarpi J
AD  - Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, 
      The Netherlands.
FAU - Voskuilen, Thijs
AU  - Voskuilen T
AD  - Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, 
      The Netherlands.
FAU - Li, Sizhe
AU  - Li S
AD  - Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, 
      The Netherlands.
FAU - van der Marel, Gijs A
AU  - van der Marel GA
AD  - Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, 
      The Netherlands.
FAU - Codee, Jeroen D C
AU  - Codee JDC
AD  - Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, 
      The Netherlands. Electronic address: jcodee@chem.leidenuniv.nl.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210412
PL  - England
TA  - Drug Discov Today Technol
JT  - Drug discovery today. Technologies
JID - 101235076
RN  - 0 (Carbohydrates)
SB  - IM
MH  - Carbohydrates
MH  - Cell Wall
MH  - *Methicillin-Resistant Staphylococcus aureus
MH  - *Staphylococcus aureus
OTO - NOTNLM
OT  - Capsular polysaccharides
OT  - Synthetic antigens
OT  - Teichoic acids
EDAT- 2021/12/14 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/12/13 11:54
PHST- 2020/11/05 00:00 [received]
PHST- 2020/12/17 00:00 [revised]
PHST- 2021/01/19 00:00 [accepted]
PHST- 2021/12/13 11:54 [entrez]
PHST- 2021/12/14 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
AID - S1740-6749(21)00005-6 [pii]
AID - 10.1016/j.ddtec.2021.01.003 [doi]
PST - ppublish
SO  - Drug Discov Today Technol. 2020 Dec;38:35-43. doi: 10.1016/j.ddtec.2021.01.003. 
      Epub 2021 Apr 12.