PMID- 34897372
OWN - NLM
STAT- MEDLINE
DCOM- 20220427
LR  - 20220427
IS  - 1528-8951 (Electronic)
IS  - 0148-0731 (Linking)
VI  - 144
IP  - 7
DP  - 2022 Jul 1
TI  - Mesoscale Simulation-Based Parametric Study of Damage Potential in Brain Tissue 
      Using Hyperelastic and Internal State Variable Models.
LID - 071005 [pii]
LID - 10.1115/1.4053205 [doi]
AB  - Two-dimensional mesoscale finite element analysis (FEA) of a multilayered brain 
      tissue was performed to calculate the damage-related average stress triaxiality 
      and local maximum von Mises strain in the brain. The FEA was integrated with 
      rate-dependent hyperelastic and internal state variable (ISV) models, 
      respectively, describing the behaviors of wet and dry brain tissues. Using the 
      finite element results, a statistical method of design of experiments (DOE) was 
      utilized to independently screen the relative influences of seven parameters 
      related to brain morphology (sulcal width/depth, gray matter (GM) thickness, 
      cerebrospinal fluid (CSF) thickness and brain lobe) and loading/environment 
      conditions (strain rate and humidity) with respect to the potential damage 
      growth/coalescence in the brain tissue. The results of the parametric study 
      illustrated that the GM thickness and humidity were the two most crucial 
      parameters affecting average stress triaxiality. For the local maximum von Mises 
      strain at the depth of brain sulci, the brain lobe/region was the most 
      influential factor. The conclusion of this investigation gives insight for the 
      future development and refinement of a macroscale brain damage model 
      incorporating information from lower length scale.
CI  - Copyright (c) 2022 by ASME.
FAU - He, Ge
AU  - He G
AD  - Shanghai Key Laboratory of Mechanics in Energy Engineering, Shanghai Institute of 
      Applied Mathematics and Mechanics, School of Mechanics and Engineering Science, 
      Shanghai University, Shanghai 200444, China.
FAU - Fan, Lei
AU  - Fan L
AD  - Department of Mechanical Engineering, Michigan State University, East Lansing, MI 
      48824.
FAU - Liu, Yucheng
AU  - Liu Y
AD  - Department of Mechanical Engineering, South Dakota State University, Brookings, 
      SD 57007.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biomech Eng
JT  - Journal of biomechanical engineering
JID - 7909584
SB  - IM
MH  - Biomechanical Phenomena
MH  - *Brain
MH  - Computer Simulation
MH  - Finite Element Analysis
MH  - *Head
MH  - Stress, Mechanical
OTO - NOTNLM
OT  - brain tissue
OT  - design of experiments
OT  - hyperelasticity
OT  - internal state variable
EDAT- 2021/12/14 06:00
MHDA- 2022/04/28 06:00
CRDT- 2021/12/13 13:23
PHST- 2021/09/15 00:00 [received]
PHST- 2021/12/14 06:00 [pubmed]
PHST- 2022/04/28 06:00 [medline]
PHST- 2021/12/13 13:23 [entrez]
AID - 1129242 [pii]
AID - 10.1115/1.4053205 [doi]
PST - ppublish
SO  - J Biomech Eng. 2022 Jul 1;144(7):071005. doi: 10.1115/1.4053205.