PMID- 34899339
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211215
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 12
DP  - 2021
TI  - Veratrilla baillonii Franch Ameliorates Diabetic Liver Injury by Alleviating 
      Insulin Resistance in Rats.
PG  - 775563
LID - 10.3389/fphar.2021.775563 [doi]
LID - 775563
AB  - Type 2 diabetes mellitus (T2DM) is a complex and polygenic disorder with diverse 
      complications. Veratrilla baillonii Franch (V. baillonii) has been applied in the 
      intervention and treatment a diverse range of diseases, including diabetes. In 
      this study, we revealed that water extracts of V. baillonii (WVBF) can ameliorate 
      liver injury and insulin resistance in T2DM rat model. To elucidate the 
      anti-diabetic mechanisms of WVBF, we performed liver transcriptome analysis that 
      displayed WVBF treatment significantly suppressed many gene expressions involved 
      in insulin resistance. Furthermore, functional experiments showed that WVBF 
      treatment reduced the pathological damages of liver and pancreas, which may be 
      regulated by Foxo1, Sirt1, G6pc, c-Met, Irs1, Akt1, Pik3r1. These results 
      indicated that WVBF improves diabetic liver injury and insulin resistance in 
      diabetic rats. Therefore, this study demonstrated WVBF could be used as a 
      promising therapeutic agent for intervention and treatment of diabetes.
CI  - Copyright (c) 2021 Zhang, Li, Li, Ma and Huang.
FAU - Zhang, Zhi-Hao
AU  - Zhang ZH
AD  - College of Pharmacy, South-Central University for Nationalities, Wuhan, China.
FAU - Li, Juan
AU  - Li J
AD  - Key Laboratory of Environmental Health, Ministry of Education, Department of 
      Toxicology, School of Public Health, Tongji Medical College, Huazhong University 
      of Science and Technology, Wuhan, China.
FAU - Li, Jun
AU  - Li J
AD  - College of Pharmacy, South-Central University for Nationalities, Wuhan, China.
FAU - Ma, Zhaowu
AU  - Ma Z
AD  - School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, 
      China.
FAU - Huang, Xian-Ju
AU  - Huang XJ
AD  - College of Pharmacy, South-Central University for Nationalities, Wuhan, China.
LA  - eng
PT  - Journal Article
DEP - 20211126
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC8662784
OTO - NOTNLM
OT  - Veratrilla baillonii franch
OT  - diabetes mellitus
OT  - diabetic liver injury
OT  - insulin resistance
OT  - transcriptome
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/12/14 06:00
MHDA- 2021/12/14 06:01
PMCR- 2021/11/26
CRDT- 2021/12/13 17:53
PHST- 2021/09/14 00:00 [received]
PHST- 2021/10/27 00:00 [accepted]
PHST- 2021/12/13 17:53 [entrez]
PHST- 2021/12/14 06:00 [pubmed]
PHST- 2021/12/14 06:01 [medline]
PHST- 2021/11/26 00:00 [pmc-release]
AID - 775563 [pii]
AID - 10.3389/fphar.2021.775563 [doi]
PST - epublish
SO  - Front Pharmacol. 2021 Nov 26;12:775563. doi: 10.3389/fphar.2021.775563. 
      eCollection 2021.