PMID- 34899367
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211215
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 12
DP  - 2021
TI  - Beneficial Effects on Brain Micro-Environment by Caloric Restriction in 
      Alleviating Neurodegenerative Diseases and Brain Aging.
PG  - 715443
LID - 10.3389/fphys.2021.715443 [doi]
LID - 715443
AB  - Aging and neurodegenerative diseases are frequently associated with the 
      disruption of the extracellular microenvironment, which includes mesenchyme and 
      body fluid components. Caloric restriction (CR) has been recognized as a 
      lifestyle intervention that can improve long-term health. In addition to 
      preventing metabolic disorders, CR has been shown to improve brain health owing 
      to its enhancing effect on cognitive functions or retarding effect on the 
      progression of neurodegenerative diseases. This article summarizes current 
      findings regarding the neuroprotective effects of CR, which include the 
      modulation of metabolism, autophagy, oxidative stress, and neuroinflammation. 
      This review may offer future perspectives for brain aging interventions.
CI  - Copyright (c) 2021 Zhang, Xu, Ding, Li, Chen and Chen.
FAU - Zhang, Li
AU  - Zhang L
AD  - Key Laboratory of Central CNS Regeneration (Ministry of Education), 
      Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, 
      Guangzhou, China.
AD  - Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong 
      Kong-Macao Greater Bay Area, Guangzhou, China.
AD  - Bioland Laboratory, Guangzhou Regenerative Medicine and Health Guangdong 
      Laboratory, Guangzhou, China.
AD  - Neuroscience and Neurorehabilitation Institute, University of Health and 
      Rehabilitation Sciences, Qingdao, China.
FAU - Xu, Huachong
AU  - Xu H
AD  - School of Traditional Chinese Medicine, Jinan University, Guangzhou, China.
FAU - Ding, Ning
AU  - Ding N
AD  - Key Laboratory of Central CNS Regeneration (Ministry of Education), 
      Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, 
      Guangzhou, China.
AD  - Medical College, Kunming University of Science and Technology, Kunming, China.
FAU - Li, Xue
AU  - Li X
AD  - School of Sports Medicine and Health, Chengdu Sport University, Chengdu, China.
FAU - Chen, Xiaoyin
AU  - Chen X
AD  - School of Traditional Chinese Medicine, Jinan University, Guangzhou, China.
FAU - Chen, Zhuangfei
AU  - Chen Z
AD  - Medical College, Kunming University of Science and Technology, Kunming, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20211125
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC8660583
OTO - NOTNLM
OT  - brain aging
OT  - cognitive functions
OT  - extracellular microenvironment
OT  - metabolic homeostasis
OT  - neuroinflammation
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/12/14 06:00
MHDA- 2021/12/14 06:01
PMCR- 2021/11/25
CRDT- 2021/12/13 17:54
PHST- 2021/05/27 00:00 [received]
PHST- 2021/10/15 00:00 [accepted]
PHST- 2021/12/13 17:54 [entrez]
PHST- 2021/12/14 06:00 [pubmed]
PHST- 2021/12/14 06:01 [medline]
PHST- 2021/11/25 00:00 [pmc-release]
AID - 10.3389/fphys.2021.715443 [doi]
PST - epublish
SO  - Front Physiol. 2021 Nov 25;12:715443. doi: 10.3389/fphys.2021.715443. eCollection 
      2021.