PMID- 34899393
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211215
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 12
DP  - 2021
TI  - Hematological and Hematopoietic Effects of Bactericidal Doses of 
      Trans-Cinnamaldehyde and Thyme Oil on Cyprinus carpio Juveniles.
PG  - 771243
LID - 10.3389/fphys.2021.771243 [doi]
LID - 771243
AB  - The effects of two potential antibacterial agents of plant origin: 
      trans-cinnamaldehyde (TC) and thyme oil (TO) on the peripheral blood parameters 
      and cellular composition of hematopoietic tissue of Cyprinus carpio were studied. 
      Both phytochemicals were used in the doses based on the bactericidal 
      concentrations against Aeromonas spp. developed earlier in in vitro study. The 
      fish were fed for 2 weeks on a commercial feed supplemented with 10 mul/kg of TC 
      or 20 mul/kg of TO. Groups TC1 and TO1 were fed diets containing phytochemicals 
      daily, while groups TC2 and TO2 every 2 days. Control group and groups TC2 and 
      TO2 on the remaining days were fed plain feed. Peripheral blood and head kidney 
      hematopoietic tissue were sampled from all the fish at the end of the experiment. 
      In all the groups, hematological values were within the reference ranges for the 
      healthy common carp juveniles. However, blood hemoglobin (Hb) concentration and 
      mean corpuscular hemoglobin concentration (MCHC) were significantly lower in all 
      the groups exposed to TC and TO, while MCH in TC1, TO1, and TO2 compared to the 
      control. TC and TO did not affect leukocyte count [white blood cell (WBC)], 
      differential leukocyte count, the oxidative activity of phagocytes [nitroblue 
      tetrazolium (NBT)], or thrombocyte count (Thro). No significant alterations were 
      observed in the hematopoietic tissue. The results showed that TC and TO exhibited 
      no considerable hematotoxic effects and trials of their use in the treatment of 
      fish infected with Aeromonas spp. may be undertaken.
CI  - Copyright (c) 2021 Kondera, Bojarski, Lugowska, Kot and Witeska.
FAU - Kondera, Elzbieta
AU  - Kondera E
AD  - Faculty of Exact and Natural Sciences, Institute of Biological Sciences, Siedlce 
      University of Natural Sciences and Humanities, Siedlce, Poland.
FAU - Bojarski, Bartosz
AU  - Bojarski B
AD  - Institute of Ichthyobiology and Aquaculture in Golysz, Polish Academy of 
      Sciences, Zaborze, Poland.
FAU - Lugowska, Katarzyna
AU  - Lugowska K
AD  - Faculty of Exact and Natural Sciences, Institute of Biological Sciences, Siedlce 
      University of Natural Sciences and Humanities, Siedlce, Poland.
FAU - Kot, Barbara
AU  - Kot B
AD  - Faculty of Exact and Natural Sciences, Institute of Biological Sciences, Siedlce 
      University of Natural Sciences and Humanities, Siedlce, Poland.
FAU - Witeska, Malgorzata
AU  - Witeska M
AD  - Faculty of Exact and Natural Sciences, Institute of Biological Sciences, Siedlce 
      University of Natural Sciences and Humanities, Siedlce, Poland.
LA  - eng
PT  - Journal Article
DEP - 20211124
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC8652124
OTO - NOTNLM
OT  - blood
OT  - fish
OT  - head kidney
OT  - phytochemicals
OT  - toxicity
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/12/14 06:00
MHDA- 2021/12/14 06:01
PMCR- 2021/11/24
CRDT- 2021/12/13 17:54
PHST- 2021/09/06 00:00 [received]
PHST- 2021/10/04 00:00 [accepted]
PHST- 2021/12/13 17:54 [entrez]
PHST- 2021/12/14 06:00 [pubmed]
PHST- 2021/12/14 06:01 [medline]
PHST- 2021/11/24 00:00 [pmc-release]
AID - 10.3389/fphys.2021.771243 [doi]
PST - epublish
SO  - Front Physiol. 2021 Nov 24;12:771243. doi: 10.3389/fphys.2021.771243. eCollection 
      2021.