PMID- 34899614
OWN - NLM
STAT- MEDLINE
DCOM- 20220218
LR  - 20220218
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 12
DP  - 2021
TI  - Comparison of Bolus and Continuous Infusion of Adrenocorticotropic Hormone During 
      Adrenal Vein Sampling.
PG  - 784706
LID - 10.3389/fendo.2021.784706 [doi]
LID - 784706
AB  - BACKGROUND: Adrenocorticotropic hormone (ACTH) is widely used in adrenal vein 
      sampling (AVS) and can be administered as a bolus injection or continuous 
      infusion. The optimal administration method has not been determined. We aimed to 
      compare the effects of ACTH bolus with infusion on cannulation success, 
      lateralization assessment and adverse events (AEs). METHODS: Retrospectively 
      collected data from patients with primary aldosteronism who underwent AVS with 
      ACTH at a tertiary hospital in China. Rate of successful cannulation, 
      lateralization index (LI), complete biochemical remission and AEs related to AVS 
      were analyzed. RESULTS: The study included 80 patients receiving ACTH bolus and 
      94 receiving infusions. The rate of successful cannulation was comparable between 
      bolus and infusion groups (75/80, 93.4% vs 88/94, 93.6%). In those with 
      successful cannulation, the bolus group had a higher selectivity index than the 
      infusion group, while LI [6.4(1.8-17.5) vs. 7.6(2.0-27.8), P=0.48] and rate of 
      complete biochemical remission (43/44, 97.7% vs 53/53, 100%, P=0.45) did not 
      significantly differ between the two groups. One in the bolus and one patient in 
      the infusion group had adrenal vein rupture but they recovered with conservative 
      treatment. The bolus group reported more transient AEs such as palpitation (52.9% 
      vs 2.2%) and abdominal discomfort (40.0% vs 2.2%) than the infusion group. 
      CONCLUSIONS: Due to their similar effects on cannulation success and 
      lateralization, but a lower rate of transient AEs in the infusion group, the 
      continuous infusion method should be recommended for ACTH stimulation in AVS.
CI  - Copyright (c) 2021 Hu, Chen, Cheng, Jing, Yang, Du, Song, Ma, Yang, Luo, Wang, Li 
      and Yang.
FAU - Hu, Jinbo
AU  - Hu J
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Chen, Jiangqiong
AU  - Chen J
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Cheng, Qingfeng
AU  - Cheng Q
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Jing, Ying
AU  - Jing Y
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Yang, Jun
AU  - Yang J
AD  - Department of Medicine, Monash University, Clayton, VIC, Australia.
AD  - Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, 
      Clayton, VIC, Australia.
FAU - Du, Zhipeng
AU  - Du Z
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Song, Ying
AU  - Song Y
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Ma, Linqiang
AU  - Ma L
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Yang, Yi
AU  - Yang Y
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Luo, Ting
AU  - Luo T
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Wang, Yue
AU  - Wang Y
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Li, Qifu
AU  - Li Q
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Yang, Shumin
AU  - Yang S
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211126
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
SB  - IM
MH  - Adrenal Glands/*blood supply/drug effects
MH  - Adrenocorticotropic Hormone/*administration & dosage
MH  - Adult
MH  - Blood Specimen Collection/*methods/standards
MH  - Catheterization/methods/standards
MH  - Female
MH  - Humans
MH  - Hyperaldosteronism/*blood/drug therapy
MH  - Infusions, Intravenous
MH  - Injections, Intravenous
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
PMC - PMC8662304
OTO - NOTNLM
OT  - adrenal
OT  - adrenal vein sampling
OT  - adrenocorticotropic hormone
OT  - hypertension
OT  - primary aldosteronism
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/12/14 06:00
MHDA- 2022/02/19 06:00
PMCR- 2021/01/01
CRDT- 2021/12/13 17:55
PHST- 2021/09/28 00:00 [received]
PHST- 2021/10/29 00:00 [accepted]
PHST- 2021/12/13 17:55 [entrez]
PHST- 2021/12/14 06:00 [pubmed]
PHST- 2022/02/19 06:00 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2021.784706 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2021 Nov 26;12:784706. doi: 
      10.3389/fendo.2021.784706. eCollection 2021.