PMID- 34900812
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221003
IS  - 2251-6581 (Print)
IS  - 2251-6581 (Electronic)
IS  - 2251-6581 (Linking)
VI  - 20
IP  - 2
DP  - 2021 Dec
TI  - Role of ferritin and oxidative stress index in gestational diabetes mellitus.
PG  - 1615-1619
LID - 10.1007/s40200-021-00911-2 [doi]
AB  - OBJECTIVES: To investigate the role of serum ferritin and oxidative stress in the 
      development of GDM and to assess their relationship with the ensuing 
      hyperglycemia. METHODS: A case-control study was carried on 90 non-anemic 
      pregnant women of 20-40 years with a gestation of 24-28 weeks. Study group 
      (n = 65) was identified according to the Diabetes in Pregnancy Study Group India 
      (DIPSI) criteria (2-h plasma glucose >/= 140 mg/dl) and controls (n = 25) having 
      2-h plasma glucose < 120 mg/dl. DIPSI 2-h plasma glucose, HbA1c and serum 
      ferritin were measured and oxidative stress index (OSI) was calculated. 
      Statistical tests were performed using SPSS version 25.0. RESULTS: Pre-pregnancy 
      BMI showed a significant difference between control and study group. DIPSI 2 h 
      blood glucose, HbA1c, serum ferritin and OSI were significantly higher in study 
      group compared to control group. Both 2 h blood glucose and HbA1c were positively 
      correlated with serum ferritin and OSI, serum ferritin and OSI were also 
      positively correlated with each other. CONCLUSION: Higher pre-pregnancy BMI 
      elevates serum ferritin, which in turn increases the OSI. Both ferritin and 
      oxidative stress raises 2 h blood glucose and HbA1c in GDM patients possibly by 
      causing in-vivo pancreatic beta -cell injury and death (ferroptosis). Serum ferritin 
      and OSI could become newer personalized theranostic and monitoring targets in 
      overweight/obese pregnant females especially GDM patients.
CI  - (c) Springer Nature Switzerland AG 2021.
FAU - Gautam, Surabhi
AU  - Gautam S
AD  - Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim 
      University, Aligarh, 202002 UP India. GRID: grid.411340.3. ISNI: 0000 0004 1937 
      0765
FAU - Alam, Feroz
AU  - Alam F
AUID- ORCID: 0000-0001-8775-0821
AD  - Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim 
      University, Aligarh, 202002 UP India. GRID: grid.411340.3. ISNI: 0000 0004 1937 
      0765
FAU - Moin, Shagufta
AU  - Moin S
AD  - Department of Biochemistry, Jawaharlal Nehru Medical College, Aligarh Muslim 
      University, Aligarh, 202002 UP India. GRID: grid.411340.3. ISNI: 0000 0004 1937 
      0765
FAU - Noor, Nasreen
AU  - Noor N
AD  - Department of Obstetrics & Gynaecology, Jawaharlal Nehru Medical College, Aligarh 
      Muslim University, Aligarh, 202002 UP India. GRID: grid.411340.3. ISNI: 0000 0004 
      1937 0765
FAU - Arif, S H
AU  - Arif SH
AD  - Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim 
      University, Aligarh, 202002 UP India. GRID: grid.411340.3. ISNI: 0000 0004 1937 
      0765
LA  - eng
PT  - Journal Article
DEP - 20211001
PL  - Switzerland
TA  - J Diabetes Metab Disord
JT  - Journal of diabetes and metabolic disorders
JID - 101590741
PMC - PMC8630333
OTO - NOTNLM
OT  - Fenton reaction
OT  - Ferritin
OT  - Ferroptosis
OT  - Gestational Diabetes Mellitus
OT  - Oxidative Stress Index
COIS- Conflict of interestNil.
EDAT- 2021/12/14 06:00
MHDA- 2021/12/14 06:01
PMCR- 2022/10/01
CRDT- 2021/12/13 18:08
PHST- 2021/07/13 00:00 [received]
PHST- 2021/09/25 00:00 [accepted]
PHST- 2021/12/13 18:08 [entrez]
PHST- 2021/12/14 06:00 [pubmed]
PHST- 2021/12/14 06:01 [medline]
PHST- 2022/10/01 00:00 [pmc-release]
AID - 911 [pii]
AID - 10.1007/s40200-021-00911-2 [doi]
PST - epublish
SO  - J Diabetes Metab Disord. 2021 Oct 1;20(2):1615-1619. doi: 
      10.1007/s40200-021-00911-2. eCollection 2021 Dec.