PMID- 34901080
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211215
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 8
DP  - 2021
TI  - Comparative Efficacy and Safety of Anterograde vs. Retrograde Iodine Staining 
      During Esophageal Chromoendoscopy: A Single-Center, Prospective, Parallel-Group, 
      Randomized, Controlled, Single-Blind Trial.
PG  - 764111
LID - 10.3389/fmed.2021.764111 [doi]
LID - 764111
AB  - Background and Aim: Chromoendoscopy with iodine staining is an important 
      diagnostic method for esophageal carcinomas or precancerous lesions. 
      Unfortunately, iodine staining can be associated with numerous adverse events 
      (AEs). We found that the starting position of spraying iodine solution is likely 
      the main reason of causing AEs. We conducted this work to determine whether 
      clinical outcomes from anterograde iodine staining were superior to those 
      achieved after retrograde iodine staining. Methods: A total of 134 subjects with 
      a health risk appraisal flushing (HRA-F) score of >6 for esophageal cancer were 
      randomly assigned to receive anterograde or retrograde iodine staining in the 
      esophagus. The primary endpoints were the pain and the amount of iodine solution 
      consumption. The secondary endpoints were iodine-staining effect, detection 
      yield, and response to starch indicator. Results: Nine patients suffered from 
      pain and six patients revealed positive response to starch indicator in 
      retrograde iodine-staining group; however, no patient reported pain (0/67) and 
      all patients revealed a negative response to starch indicator in anterograde 
      iodine-staining group. The amount of iodine solution consumption in anterograde 
      iodine-staining group (4.97 mL) was significantly lower than that (6.23 mL) in 
      retrograde iodine-staining group; however, the iodine-staining effect and 
      detection yield were comparable between the two groups. Conclusions: Anterograde 
      iodine staining during Lugol chromoendoscopy appears to be as effective, but 
      significantly safer than retrograde iodine staining.
CI  - Copyright (c) 2021 Tian, Yang and Chen.
FAU - Tian, Xu
AU  - Tian X
AD  - Nursing Department, Universitat Rovira i Virgili, Tarragona, Spain.
FAU - Yang, Wei
AU  - Yang W
AD  - Department of Gastroenterology, Chongqing University Cancer Hospital, Chongqing, 
      China.
FAU - Chen, Wei-Qing
AU  - Chen WQ
AD  - Department of Gastroenterology, Chongqing University Cancer Hospital, Chongqing, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20211125
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC8655331
OTO - NOTNLM
OT  - chromoendoscopy
OT  - endoscopic screening
OT  - esophageal cancer
OT  - iodine solution
OT  - staining
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/12/14 06:00
MHDA- 2021/12/14 06:01
PMCR- 2021/11/25
CRDT- 2021/12/13 18:09
PHST- 2021/08/25 00:00 [received]
PHST- 2021/11/01 00:00 [accepted]
PHST- 2021/12/13 18:09 [entrez]
PHST- 2021/12/14 06:00 [pubmed]
PHST- 2021/12/14 06:01 [medline]
PHST- 2021/11/25 00:00 [pmc-release]
AID - 10.3389/fmed.2021.764111 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2021 Nov 25;8:764111. doi: 10.3389/fmed.2021.764111. 
      eCollection 2021.