PMID- 34901284
OWN - NLM
STAT- MEDLINE
DCOM- 20220120
LR  - 20220120
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2021
DP  - 2021
TI  - hsa_circ_0023305 Enhances Laryngeal Squamous Cell Carcinoma Progression and 
      Modulates TRPM7 via miR-218-5p Sponging.
PG  - 9968499
LID - 10.1155/2021/9968499 [doi]
LID - 9968499
AB  - Recently, circular RNAs have been shown to function as critical regulators of 
      many human cancers. However, the circRNA mechanism in laryngeal squamous cell 
      carcinoma (LSCC) remains elusive. Recent investigations using bioinformatics 
      analysis revealed high expression of hsa_circ_0023305 in LSCC tissues compared to 
      normal tissues. Furthermore, we discovered that hsa_circ_0023305 expression level 
      was positively correlated to tumor/node/metastasis (TNM) stage as well as lymph 
      node metastasis in LSCC. Moreover, higher hsa_circ_0023305 levels were correlated 
      to poorer LSCC patient outcomes. Knockdown of hsa_circ_0023305 significantly 
      inhibited LSCC cell proliferation, invasion, and migration abilities. Our team 
      validated that hsa_circ_0023305 functioned as a miR-218-5p sponge from a 
      mechanistic perspective, targeting the melastatin-related transient receptor 
      potential 7 (TRPM7) in LSCC cells. TRPM7 regulates a nonselective cation channel 
      and promotes cancer proliferation and metastasis. Our data demonstrated that 
      miR-218-5p was downregulated in LSCC and that miR-218-5p upregulation repressed 
      LSCC proliferation and invasion both in vivo and in vitro. Additionally, we found 
      that hsa_circ_0023305-mediated upregulation of TRPM7 inhibited miR-218-5p and 
      contributed to LSCC migration, proliferation, and invasion. In summary, these 
      data propose a new mechanism by which the hsa_circ_0023305/miR-218-5p/TRPM7 
      network enhances LSCC progression.
CI  - Copyright (c) 2021 Yi Zhang et al.
FAU - Zhang, Yi
AU  - Zhang Y
AUID- ORCID: 0000-0003-1539-7322
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Pudong New Area 
      Gongli Hospital, Shanghai 200135, China.
FAU - Tian, Kaisai
AU  - Tian K
AD  - Ningxia Medical University, Yinchuan, Ningxia 750004, China.
FAU - Zhou, Enhui
AU  - Zhou E
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Pudong New Area 
      Gongli Hospital, Shanghai 200135, China.
FAU - Xue, Xiaocheng
AU  - Xue X
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Pudong New Area 
      Gongli Hospital, Shanghai 200135, China.
FAU - Yan, Shiling
AU  - Yan S
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Pudong New Area 
      Gongli Hospital, Shanghai 200135, China.
FAU - Chen, Yixin
AU  - Chen Y
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Pudong New Area 
      Gongli Hospital, Shanghai 200135, China.
FAU - Qiao, Peipei
AU  - Qiao P
AD  - Ningxia Medical University, Yinchuan, Ningxia 750004, China.
FAU - Yang, Liyun
AU  - Yang L
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Pudong New Area 
      Gongli Hospital, Shanghai 200135, China.
FAU - Chen, Xiaoping
AU  - Chen X
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Pudong New Area 
      Gongli Hospital, Shanghai 200135, China.
LA  - eng
PT  - Journal Article
DEP - 20211202
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (MIRN218 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Circular)
RN  - 0 (TRPM Cation Channels)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (TRPM7 protein, human)
SB  - IM
MH  - Animals
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics
MH  - Cell Proliferation/genetics
MH  - Disease Progression
MH  - Down-Regulation/genetics
MH  - Gene Expression Regulation, Neoplastic/genetics
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/pathology
MH  - Lymphatic Metastasis/genetics/pathology
MH  - Mice
MH  - MicroRNAs/*genetics
MH  - Protein Serine-Threonine Kinases/*genetics
MH  - RNA, Circular/*genetics
MH  - Squamous Cell Carcinoma of Head and Neck/*genetics/pathology
MH  - TRPM Cation Channels/*genetics
MH  - Up-Regulation/genetics
PMC - PMC8660181
COIS- None is declared.
EDAT- 2021/12/14 06:00
MHDA- 2022/01/21 06:00
PMCR- 2021/12/02
CRDT- 2021/12/13 18:10
PHST- 2021/03/08 00:00 [received]
PHST- 2021/11/07 00:00 [revised]
PHST- 2021/11/08 00:00 [accepted]
PHST- 2021/12/13 18:10 [entrez]
PHST- 2021/12/14 06:00 [pubmed]
PHST- 2022/01/21 06:00 [medline]
PHST- 2021/12/02 00:00 [pmc-release]
AID - 10.1155/2021/9968499 [doi]
PST - epublish
SO  - Biomed Res Int. 2021 Dec 2;2021:9968499. doi: 10.1155/2021/9968499. eCollection 
      2021.