PMID- 34902249
OWN - NLM
STAT- MEDLINE
DCOM- 20220331
LR  - 20220331
IS  - 1520-6025 (Electronic)
IS  - 0163-3864 (Linking)
VI  - 84
IP  - 12
DP  - 2021 Dec 24
TI  - Evodiamine Lowers Blood Lipids by Up-Regulating the PPARgamma/ABCG1 Pathway in 
      High-Fat-Diet-Fed Mice.
PG  - 3110-3116
LID - 10.1021/acs.jnatprod.1c00881 [doi]
AB  - The natural alkaloid evodiamine enhances cholesterol efflux from cultured 
      THP-1-derived macrophages, but whether it has any impact on blood lipids in vivo 
      remains unknown. In this study, the effect of evodiamine on hyperlipidemia 
      induced by a high-fat diet (HFD) was investigated in mice. Intragastric 
      administrations of evodiamine (10 and 20 mg/kg) for 8 weeks resulted in a 
      significant improvement of metabolic lipid profiles by reducing the plasma levels 
      of triglycerides (TG), total cholesterol (TC), and low-density lipoprotein 
      cholesterol (LDL-C). Evodiamine also significantly decreased hepatic lipid 
      accumulation and hepatic total bile acids (TBA). Mechanistically, evodiamine 
      increased ATP-binding cassette transporter G1 (ABCG1) mRNA and protein expression 
      and up-regulated peroxisome proliferator-activated receptor gamma (PPARgamma) 
      expression in the liver. Taken together, the natural product evodiamine lowers 
      blood lipids in HFD-fed mice likely through promoting the PPARgamma-ABCG1 signaling 
      pathway.
FAU - Hou, Xingming
AU  - Hou X
AD  - Department of Pharmacology, School of Pharmacy, Qingdao University Medical 
      College, Qingdao 266073, Shandong, China.
FAU - Malainer, Clemens
AU  - Malainer C
AD  - Department of Pharmaceutical Sciences, Faculty of Life Science, University of 
      Vienna, Althanstrasse 14, 1090 Vienna, Austria.
FAU - Atanasov, Atanas G
AU  - Atanasov AG
AD  - Department of Pharmaceutical Sciences, Faculty of Life Science, University of 
      Vienna, Althanstrasse 14, 1090 Vienna, Austria.
AD  - Ludwig Boltzmann Institute for Digital Health and Patient Safety, Medical 
      University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.
AD  - Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, 
      Jastrzebiec, 05-552 Magdalenka, Poland.
FAU - Heiss, Elke H
AU  - Heiss EH
AD  - Department of Pharmaceutical Sciences, Faculty of Life Science, University of 
      Vienna, Althanstrasse 14, 1090 Vienna, Austria.
FAU - Dirsch, Verena M
AU  - Dirsch VM
AUID- ORCID: 0000-0002-9261-5293
AD  - Department of Pharmaceutical Sciences, Faculty of Life Science, University of 
      Vienna, Althanstrasse 14, 1090 Vienna, Austria.
FAU - Wang, Limei
AU  - Wang L
AUID- ORCID: 0000-0002-0333-5063
AD  - Department of Pharmacology, School of Pharmacy, Qingdao University Medical 
      College, Qingdao 266073, Shandong, China.
AD  - Institute of Innovative Drugs, Qingdao University, Qingdao 266071, Shandong, 
      China.
FAU - Wang, KeWei
AU  - Wang K
AUID- ORCID: 0000-0001-7023-9998
AD  - Department of Pharmacology, School of Pharmacy, Qingdao University Medical 
      College, Qingdao 266073, Shandong, China.
AD  - Institute of Innovative Drugs, Qingdao University, Qingdao 266071, Shandong, 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211213
PL  - United States
TA  - J Nat Prod
JT  - Journal of natural products
JID - 7906882
RN  - 0 (ABCG1 protein, mouse)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily G, Member 1)
RN  - 0 (Bile Acids and Salts)
RN  - 0 (Lipids)
RN  - 0 (PPAR gamma)
RN  - 0 (Plant Extracts)
RN  - 0 (Quinazolines)
RN  - C01825BVNL (evodiamine)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily G, Member 1/*metabolism
MH  - Animals
MH  - Bile Acids and Salts/metabolism
MH  - Body Weight/drug effects
MH  - *Diet, High-Fat
MH  - Lipids/*blood
MH  - Liver/drug effects/metabolism
MH  - Mice
MH  - PPAR gamma/*metabolism
MH  - Plant Extracts/pharmacology
MH  - Quinazolines/*pharmacology
EDAT- 2021/12/14 06:00
MHDA- 2022/04/01 06:00
CRDT- 2021/12/13 20:11
PHST- 2021/12/14 06:00 [pubmed]
PHST- 2022/04/01 06:00 [medline]
PHST- 2021/12/13 20:11 [entrez]
AID - 10.1021/acs.jnatprod.1c00881 [doi]
PST - ppublish
SO  - J Nat Prod. 2021 Dec 24;84(12):3110-3116. doi: 10.1021/acs.jnatprod.1c00881. Epub 
      2021 Dec 13.