PMID- 34902718
OWN - NLM
STAT- MEDLINE
DCOM- 20220111
LR  - 20220111
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1662
DP  - 2022 Jan 11
TI  - Amphiphilic copolymers grafted on monodisperse magnetic microspheres as an 
      efficient adsorbent for the extraction of safrole in the plasma.
PG  - 462733
LID - S0021-9673(21)00855-4 [pii]
LID - 10.1016/j.chroma.2021.462733 [doi]
AB  - Polystyrene (PS) microsphere is a kind of attractive extracting medium due to its 
      high stability in different matrices and its particle size can be controlled. The 
      attachment of amphiphilic copolymers to the PS microsphere surface can overcome 
      the drawback of PS relevant to its hydrophobic nature and low wettability. In our 
      previous work, the magnetic composite based on PS microsphere (5 microm) and poly 
      (divinylbenzene-co-N-vinylpyrrolidone, DVB-co-NVP) shell was successfully 
      fabricated and applied for the extraction of safrole in cola drinks. However, the 
      large size and ease of sedimentation limited its application in the enrichment of 
      safrole from blood samples. Considering the adjustability of PS microsphere size, 
      we synthesized the porous PS microspheres with the uniform size of 3 microm and then 
      functionalized with Fe(3)O(4) nanoparticles and poly (DVB-co-NVP) layer in this 
      work. Using the proposed material as extraction sorbent, a simple and fast 
      magnetic solid phase extraction (MSPE) method coupled with HPLC was developed for 
      quantification of safrole in the plasma. Under the optimized conditions, the 
      response to safrole was linear in the range of 0.02-12 microg mL(-1), and the limit 
      of detection (LOD) was 0.006 microg mL(-1). Satisfactory recoveries were obtained 
      between 85.67% and 97.74% (spiked at 0.05, 0.2, 2 microg mL(-1)) and the relative 
      standard deviations (RSDs) for the above spiked levels of the analyte were below 
      3.9% (n = 6). The adsorbent can be reused for 6 cycles without a significant loss 
      of extraction capability.
CI  - Copyright (c) 2021. Published by Elsevier B.V.
FAU - Nie, Ying
AU  - Nie Y
AD  - College of Medical Technology, Chengdu University of Traditional Chinese 
      Medicine, 1166 Liutai Avenue, Chengdu, Sichuan 611137, China.
FAU - Luo, Yuan
AU  - Luo Y
AD  - College of Medical Technology, Chengdu University of Traditional Chinese 
      Medicine, 1166 Liutai Avenue, Chengdu, Sichuan 611137, China.
FAU - Luo, Shajie
AU  - Luo S
AD  - College of Medical Technology, Chengdu University of Traditional Chinese 
      Medicine, 1166 Liutai Avenue, Chengdu, Sichuan 611137, China.
FAU - Cao, Xiujun
AU  - Cao X
AD  - College of Medical Technology, Chengdu University of Traditional Chinese 
      Medicine, 1166 Liutai Avenue, Chengdu, Sichuan 611137, China; Research Center of 
      Analysis and Measurement, Fudan University, 2005 Songhu Road, Shanghai 200438, 
      China; Department of Chemistry, The University of Warwick, Coventry, CV4 7AL, UK. 
      Electronic address: 072037001@fudan.edu.cn.
FAU - Song, Guoxin
AU  - Song G
AD  - Research Center of Analysis and Measurement, Fudan University, 2005 Songhu Road, 
      Shanghai 200438, China. Electronic address: gxsong@fudan.edu.cn.
FAU - Deng, Chunhui
AU  - Deng C
AD  - Department of Chemistry, Institutes of Biomedical Sciences, Fudan University, 
      2005 Songhu Road, Shanghai 200438, China.
LA  - eng
PT  - Journal Article
DEP - 20211204
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - RSB34337V9 (Safrole)
SB  - IM
MH  - Adsorption
MH  - Chromatography, High Pressure Liquid
MH  - Limit of Detection
MH  - Magnetic Phenomena
MH  - Microspheres
MH  - *Safrole
MH  - *Solid Phase Extraction
OTO - NOTNLM
OT  - Amphiphilic copolymers
OT  - Magnetic solid phase extraction
OT  - Plasma
OT  - Polystyrene
OT  - Safrole
COIS- Declaration of Competing Interest We declare that we have no financial and 
      personal relationships with other people or organizations that can 
      inappropriately influence our work, there is no professional or other personal 
      interest of any nature or kind in any product, service and/or company that could 
      be construed as influencing the position presented in, or the review of, the 
      manuscript entitled.
EDAT- 2021/12/14 06:00
MHDA- 2022/01/12 06:00
CRDT- 2021/12/13 20:23
PHST- 2021/08/09 00:00 [received]
PHST- 2021/11/27 00:00 [revised]
PHST- 2021/12/02 00:00 [accepted]
PHST- 2021/12/14 06:00 [pubmed]
PHST- 2022/01/12 06:00 [medline]
PHST- 2021/12/13 20:23 [entrez]
AID - S0021-9673(21)00855-4 [pii]
AID - 10.1016/j.chroma.2021.462733 [doi]
PST - ppublish
SO  - J Chromatogr A. 2022 Jan 11;1662:462733. doi: 10.1016/j.chroma.2021.462733. Epub 
      2021 Dec 4.