PMID- 34906654
OWN - NLM
STAT- MEDLINE
DCOM- 20220214
LR  - 20220214
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 159
DP  - 2022 Jan
TI  - Gestational exposure to acrylamide suppresses luteal endocrine function through 
      dysregulation of ovarian angiogenesis, oxidative stress and apoptosis in mice.
PG  - 112766
LID - S0278-6915(21)00799-7 [pii]
LID - 10.1016/j.fct.2021.112766 [doi]
AB  - The discovery of acrylamide in various carbohydrate-rich foods cooked at high 
      temperatures has attracted public health concerns. This study aimed to elucidate 
      the effects and mechanisms additional with acrylamide exposure on the luteal 
      function in vivo during early- and mid-pregnancy. Mice were fed with different 
      dosages of acrylamide (0, 10 and 50 mg/kg/day) by gavage from gestational days 
      (GD) 3 to GD 8 or GD 13. The results indicated that acrylamide exposure 
      significantly decreased levels of serum progesterone and estradiol, and the 
      numbers and relative areas of ovarian corpora lutea. The expression levels of 
      Hsd3b1, Cyp11a1 and Star mRNA markedly reduced in acrylamide-treated ovaries. 
      Furthermore, acrylamide exposure obviously suppressed the activities of catalase 
      and superoxide dismutase, but increased the levels of H(2)O(2) and 
      malondialdehyde. Additionally, acrylamide treatment significantly inhibited 
      luteal angiogenesis and induced the apoptosis of ovarian cells by up-regulation 
      of P53 and Bax protein and down-regulation of Bcl-2 protein. Thus, our results 
      showed that gestational exposure to acrylamide significantly inhibited luteal 
      endocrine function via dysregulation of ovarian angiogenesis, oxidative stress 
      and apoptosis in vivo.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Yu, Dainan
AU  - Yu D
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi, 330006, PR China. Electronic address: 1747060467@qq.com.
FAU - Jiang, Xun
AU  - Jiang X
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi, 330006, PR China; Department of Clinic Medicine, The First Clinical 
      Medical College, Nanchang University, Nanchang, Jiangxi, 330006, PR China. 
      Electronic address: jx1757784513@163.com.
FAU - Ge, Wenjing
AU  - Ge W
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi, 330006, PR China; Department of Clinical Medicine, School of Queen Mary, 
      Nanchang University, Nanchang, Jiangxi, 330006, PR China. Electronic address: 
      gracelovefruit@outlook.com.
FAU - Qiao, Bo
AU  - Qiao B
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi, 330006, PR China. Electronic address: qiaoxiaogu@163.com.
FAU - Zhang, Dalei
AU  - Zhang D
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi, 330006, PR China. Electronic address: zhangdalei@ncu.edu.cn.
FAU - Liu, Hui
AU  - Liu H
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi, 330006, PR China. Electronic address: hhcomeon@126.com.
FAU - Kuang, Haibin
AU  - Kuang H
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi, 330006, PR China; Jiangxi Provincial Key Laboratory of Reproductive 
      Physiology and Pathology, Medical Experimental Teaching Center, Nanchang 
      University, Nanchang, Jiangxi, 330006, PR China. Electronic address: 
      kuanghaibin@ncu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20211211
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 20R035KLCI (Acrylamide)
SB  - IM
MH  - Acrylamide/*toxicity
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Corpus Luteum/*drug effects
MH  - Female
MH  - Male
MH  - Mice
MH  - Neovascularization, Physiologic/drug effects
MH  - *Ovary/blood supply/drug effects/physiopathology
MH  - Oxidative Stress/*drug effects
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
OTO - NOTNLM
OT  - Acrylamide
OT  - Corpus luteum
OT  - Endocrine
OT  - Ovary
OT  - Pregnancy
EDAT- 2021/12/16 06:00
MHDA- 2022/02/15 06:00
CRDT- 2021/12/15 06:01
PHST- 2021/09/26 00:00 [received]
PHST- 2021/11/30 00:00 [revised]
PHST- 2021/12/08 00:00 [accepted]
PHST- 2021/12/16 06:00 [pubmed]
PHST- 2022/02/15 06:00 [medline]
PHST- 2021/12/15 06:01 [entrez]
AID - S0278-6915(21)00799-7 [pii]
AID - 10.1016/j.fct.2021.112766 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2022 Jan;159:112766. doi: 10.1016/j.fct.2021.112766. Epub 2021 
      Dec 11.