PMID- 34908197
OWN - NLM
STAT- MEDLINE
DCOM- 20220804
LR  - 20220912
IS  - 1365-277X (Electronic)
IS  - 0952-3871 (Linking)
VI  - 35
IP  - 4
DP  - 2022 Aug
TI  - Interaction between CETP Taq1B polymorphism and HEI, DQI and DPI on metabolic 
      biomarkers in patients with type 2 diabetes.
PG  - 651-662
LID - 10.1111/jhn.12958 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is a multidimensional consequence of 
      environmental and genetic factors. Cholesteryl ester transfer protein (CETP) 
      Taq1B polymorphism has been reported as a main predictor of dyslipidaemia, 
      comprising an important complication in persons with T2DM. However, diet could 
      affect T2DM patients metabolic health. METHODS: We investigated the combination 
      of gene-diet effects on some metabolic biomarkers. In our cross-sectional study, 
      blood samples of 220 patients were collected. Dietary indices (healthy eating 
      index, dietary quality index and dietary phytochemical index) were obtained from 
      a validated semi-quantitative food frequency questionnaire. CETP Taq1B 
      polymorphism was genotyped by a polymerase chain reaction-restriction fragment 
      polymorphism method. Data were analysed by analysis of covariance. RESULTS: The 
      interaction between the CETP Taq1B polymorphism and dietary indices on low 
      density lipoprotein/high density lipoprotein was significant (p < 0.001 both 
      crude and adjusted models). In addition, the interaction between polymorphism and 
      dietary quality index on total antioxidant capacity (p = 0.004 crude model, 
      p = 0.005 after adjusting) and pentraxin 3 (p = 0.01 both crude and adjusted 
      models) was significant. Also, the interaction between polymorphism and healthy 
      eating index on waist circumference (p = 0.005 both crude and adjusted models) 
      and dietary phytochemical index on interleukin-18 (p = 0.03 crude model) was 
      significant. CONCLUSIONS: Our results indicated the effect of CETP Taq1B 
      polymorphism on some inflammatory and anthropometrics markers (total antioxidant 
      capacity, pentraxin 3, interleukin-18, low density lipoprotein/high density 
      lipoprotein and waist circumference) with high and low adherence to dietary 
      incides.
CI  - (c) 2021 The British Dietetic Association Ltd.
FAU - Kalantar, Zahra
AU  - Kalantar Z
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Sotoudeh, Gity
AU  - Sotoudeh G
AUID- ORCID: 0000-0001-6541-2581
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Esmaeily, Zahra
AU  - Esmaeily Z
AUID- ORCID: 0000-0003-0353-4457
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Rafiee, Masoumeh
AU  - Rafiee M
AD  - Department of Clinical Nutrition, School of Nutrition & Food sciences, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
FAU - Koohdani, Fariba
AU  - Koohdani F
AUID- ORCID: 0000-0002-7108-5350
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
AD  - Diabetic Research Center, Endocrinology and Metabolism Clinical Sciences 
      Institute, Tehran University of Medical Sciences, Tehran, Iran.
LA  - eng
GR  - 92-03-161-24464/Tehran University of Medical Sciences/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211214
PL  - England
TA  - J Hum Nutr Diet
JT  - Journal of human nutrition and dietetics : the official journal of the British 
      Dietetic Association
JID - 8904840
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (CETP protein, human)
RN  - 0 (Cholesterol Ester Transfer Proteins)
RN  - 0 (Interleukin-18)
RN  - 0 (Lipoproteins, HDL)
RN  - 0 (Lipoproteins, LDL)
SB  - IM
MH  - Antioxidants
MH  - Biomarkers
MH  - *Cholesterol Ester Transfer Proteins/genetics
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/genetics
MH  - Genotype
MH  - Humans
MH  - Interleukin-18/genetics
MH  - Lipoproteins, HDL/genetics
MH  - Lipoproteins, LDL/genetics
OTO - NOTNLM
OT  - CETP Taq1B polymorphism
OT  - T2DM
OT  - dietary indices
OT  - metabolic biomarkers
EDAT- 2021/12/16 06:00
MHDA- 2022/08/05 06:00
CRDT- 2021/12/15 09:02
PHST- 2021/04/11 00:00 [received]
PHST- 2021/09/19 00:00 [accepted]
PHST- 2021/12/16 06:00 [pubmed]
PHST- 2022/08/05 06:00 [medline]
PHST- 2021/12/15 09:02 [entrez]
AID - 10.1111/jhn.12958 [doi]
PST - ppublish
SO  - J Hum Nutr Diet. 2022 Aug;35(4):651-662. doi: 10.1111/jhn.12958. Epub 2021 Dec 
      14.