PMID- 34908244
OWN - NLM
STAT- MEDLINE
DCOM- 20220314
LR  - 20220314
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 25
IP  - 2
DP  - 2022 Feb
TI  - Increased gene expression of B cell-activating factor of tumor necrosis factor 
      family, in remitting antineutrophil cytoplasmic antibody-associated vasculitis 
      patients.
PG  - 218-227
LID - 10.1111/1756-185X.14262 [doi]
AB  - AIM: To study the expression of B cell-activating factor of tumor necrosis factor 
      family (BAFF) and A proliferation-inducing ligand (APRIL) genes in active and 
      remitting patients with anti-neutrophil cytoplasmic antibody-associated 
      vasculitis (AAV) and healthy controls and their correlation with disease 
      activity. METHODS: This was a prospective case-control study. Gene expressions of 
      BAFF and APRIL were studied in 32 patients with AAV (16 each with active disease 
      and in remission) and 30 healthy age and sex matched controls by real-time 
      polymerase chain reaction. RESULTS: Out of 32 AAV patients, 26 had granulomatosis 
      with polyangiitis (GPA) and 6 had microscopic polyangiitis (MPA). Mean ages of 
      patients in active (12 GPA and 4 MPA) and remission (14 GPA and 2 MPA) groups 
      were 39.4 +/- 17.2 and 44.6 +/- 16.1 years, respectively. BAFF gene expression was 
      significantly higher in both the active AAV group and remission AAV group 
      compared to controls (P < .01). The BAFF expression was significantly higher in 
      AAV patients in remission compared to active AAV patients (P = .003). In 
      contrast, APRIL expression did not differ between AAV patients and controls 
      (P = .829). However, APRIL had significantly higher expression in remission as 
      compared to active patients (P = .048). There was no significant correlation of 
      both BAFF and APRIL expression with disease activity markers (erythrocyte 
      sedimentation rate, C-reactive protein, platelets and Birmingham Vasculitis 
      Activity Score version 3). CONCLUSION: BAFF gene is significantly expressed in 
      patients with AAV. Among AAV patients, there is a significantly higher expression 
      of BAFF and APRIL in remitting state of the disease as compared to active state. 
      There is no significant change in APRIL gene expression in patients with AAV as 
      compared to controls. This makes a case for anti-BAFF therapy in future for AAV 
      patients in northern India.
CI  - (c) 2021 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons 
      Australia, Ltd.
FAU - Jha, Saket
AU  - Jha S
AUID- ORCID: 0000-0001-9011-464X
AD  - Clinical Immunology and Rheumatology Wing, Department of Internal Medicine, 
      Postgraduate Institute of Medical Education and Research, Chandigarh, India.
FAU - Singh, Jagdeep
AU  - Singh J
AUID- ORCID: 0000-0003-4539-5870
AD  - Department of Immunopathology, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Minz, Ranjana W
AU  - Minz RW
AUID- ORCID: 0000-0003-1304-542X
AD  - Department of Immunopathology, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Dhooria, Aadhar
AU  - Dhooria A
AUID- ORCID: 0000-0002-1680-0585
AD  - Clinical Immunology and Rheumatology Wing, Department of Internal Medicine, 
      Postgraduate Institute of Medical Education and Research, Chandigarh, India.
FAU - Naidu, Gsrsnk
AU  - Naidu G
AUID- ORCID: 0000-0002-9727-044X
AD  - Clinical Immunology and Rheumatology Wing, Department of Internal Medicine, 
      Postgraduate Institute of Medical Education and Research, Chandigarh, India.
FAU - Ranjan Kumar, Rajiv
AU  - Ranjan Kumar R
AUID- ORCID: 0000-0002-9743-2541
AD  - Clinical Immunology and Rheumatology Wing, Department of Internal Medicine, 
      Postgraduate Institute of Medical Education and Research, Chandigarh, India.
FAU - Rathi, Manish
AU  - Rathi M
AD  - Department of Nephrology, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Jain, Sanjay
AU  - Jain S
AD  - Clinical Immunology and Rheumatology Wing, Department of Internal Medicine, 
      Postgraduate Institute of Medical Education and Research, Chandigarh, India.
FAU - Anand, Shashi
AU  - Anand S
AD  - Department of Immunopathology, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Sharma, Aman
AU  - Sharma A
AUID- ORCID: 0000-0003-0813-1243
AD  - Clinical Immunology and Rheumatology Wing, Department of Internal Medicine, 
      Postgraduate Institute of Medical Education and Research, Chandigarh, India.
LA  - eng
GR  - Indian Rheumatology Association/
PT  - Journal Article
DEP - 20211215
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
RN  - 0 (B-Cell Activating Factor)
RN  - 0 (TNFSF13B protein, human)
SB  - IM
MH  - Adult
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated 
      Vasculitis/*genetics/physiopathology
MH  - B-Cell Activating Factor/*metabolism
MH  - Case-Control Studies
MH  - Female
MH  - Gene Expression
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Real-Time Polymerase Chain Reaction
OTO - NOTNLM
OT  - ANCA-associated vasculitis
OT  - APRIL
OT  - BAFF
OT  - correlation
OT  - gene expression
EDAT- 2021/12/16 06:00
MHDA- 2022/03/15 06:00
CRDT- 2021/12/15 09:05
PHST- 2021/10/14 00:00 [revised]
PHST- 2021/06/23 00:00 [received]
PHST- 2021/11/15 00:00 [accepted]
PHST- 2021/12/16 06:00 [pubmed]
PHST- 2022/03/15 06:00 [medline]
PHST- 2021/12/15 09:05 [entrez]
AID - 10.1111/1756-185X.14262 [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2022 Feb;25(2):218-227. doi: 10.1111/1756-185X.14262. Epub 2021 
      Dec 15.