PMID- 34909047
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240404
IS  - 1735-5362 (Print)
IS  - 1735-9414 (Electronic)
IS  - 1735-5362 (Linking)
VI  - 17
IP  - 1
DP  - 2022 Feb
TI  - Determination of plasma and erythrocyte levels of copper, magnesium and zinc by 
      atomic absorption spectrometry in type-2 diabetes mellitus patients with 
      metabolic syndrome.
PG  - 86-98
LID - 10.4103/1735-5362.329929 [doi]
AB  - BACKGROUND AND PURPOSE: Imbalance in blood levels of trace elements is 
      independent risk factor for metabolic syndrome (MetS), type 2 diabetes mellitus 
      (T2DM), and its complications. This study investigated plasma and erythrocyte 
      levels of copper, magnesium, zinc, and their correlations with biochemical 
      components of the MetS in T2DM patients compared to the healthy controls. 
      EXPERIMENTAL APPROACH: Forty men recently diagnosed T2DM with MetS without 
      complications and thirty six age-matched healthy controls were enrolled in this 
      cross-sectional study. Plasma and erythrocyte levels of selected elements were 
      measured by graphite furnace atomic absorption spectroscopy. FINDINGS/RESULTS: 
      The results of the present study showed significantly lower plasma levels of 
      copper, magnesium, and zinc and lower erythrocytes copper in the patients' group 
      compared to the controls; while erythrocyte levels of magnesium and zinc were not 
      significantly different between the two groups. Significant negative correlations 
      were observed between plasma levels of copper with waist and hip circumferences, 
      waist to hip ratio, systolic and diastolic blood pressures, fasting blood 
      glucose, and glycated hemoglobin levels in all subjects; while erythrocyte copper 
      levels showed significant negative correlation with triglyceride, and erythrocyte 
      zinc was positively correlated with diastolic blood pressure and negatively with 
      triglyceride. CONCLUSION AND IMPLICATIONS: Alterations of trace elements may have 
      a significant role in the pathogenesis of MetS and T2DM patients. It is suggested 
      that the body status of copper, magnesium, and zinc might be significantly 
      correlated with components of MetS in T2DM patients; and plasma copper levels may 
      be correlated with complications of type 2 diabetes mellitus.
CI  - Copyright: (c) 2021 Research in Pharmaceutical Sciences.
FAU - Omidian, Amin
AU  - Omidian A
AD  - Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical 
      Sciences, Isfahan University of Medical Sciences, I.R. Iran.
FAU - Pourfarzam, Morteza
AU  - Pourfarzam M
AD  - Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical 
      Sciences, Isfahan University of Medical Sciences, I.R. Iran.
FAU - Ghanadian, Seyed Mostafa
AU  - Ghanadian SM
AD  - Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, 
      Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
FAU - Zadhoush, Fouzieh
AU  - Zadhoush F
AD  - Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical 
      Sciences, Isfahan University of Medical Sciences, I.R. Iran.
LA  - eng
PT  - Journal Article
DEP - 20211111
PL  - Iran
TA  - Res Pharm Sci
JT  - Research in pharmaceutical sciences
JID - 101516968
PMC - PMC8621840
OTO - NOTNLM
OT  - Atomic absorption spectrometry
OT  - Copper
OT  - Diabetes mellitus
OT  - Magnesium
OT  - Metabolic syndrome
OT  - Zinc
COIS- The authors declared no conflict of interest in this study.
EDAT- 2021/12/16 06:00
MHDA- 2021/12/16 06:01
PMCR- 2021/11/11
CRDT- 2021/12/15 12:27
PHST- 2020/10/27 00:00 [received]
PHST- 2021/01/19 00:00 [revised]
PHST- 2021/08/23 00:00 [accepted]
PHST- 2021/12/15 12:27 [entrez]
PHST- 2021/12/16 06:00 [pubmed]
PHST- 2021/12/16 06:01 [medline]
PHST- 2021/11/11 00:00 [pmc-release]
AID - RPS-17-86 [pii]
AID - 10.4103/1735-5362.329929 [doi]
PST - epublish
SO  - Res Pharm Sci. 2021 Nov 11;17(1):86-98. doi: 10.4103/1735-5362.329929. 
      eCollection 2022 Feb.