PMID- 34909331
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211217
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 13
IP  - 11
DP  - 2021 Nov
TI  - Failed Emergence After Pediatric Epilepsy Surgery: Is Propofol-Related Infusion 
      Syndrome to Blame?
PG  - e19414
LID - 10.7759/cureus.19414 [doi]
LID - e19414
AB  - Propofol infusion syndrome was first reported in the literature by Bray in 1998. 
      He described a series of fatal outcomes after a presenting constellation of 
      symptoms observed in pediatric patients who had received prolonged propofol 
      infusions. Profound metabolic acidosis and bradycardia are the disease's hallmark 
      features, which can further develop expeditiously to rhabdomyolysis, renal 
      failure, and heart failure. It has been subsequently theorized that a triggering 
      mechanism or a precipitating factor sets up the progressive physiologic spiral 
      which can ensue. The name of the disease was expanded to Propofol Related 
      Infusion Syndrome (PRIS), as propofol alone was no longer considered the culprit. 
      The disease process is rare and can present with an insidious onset in some 
      cases, causing much speculation of whether there is a proper grasp of the disease 
      entity in its entirety as currently reported. The case discussed in this article 
      depicts an adverse neurologic outcome following a craniotomy for temporal 
      lobectomy in a child with lesional epilepsy. Since there was no obvious causative 
      factor for these findings, PRIS became a diagnosis that was robustly discussed 
      among the involved services.
CI  - Copyright (c) 2021, Doherty et al.
FAU - Doherty, Tara M
AU  - Doherty TM
AD  - Pediatric Anesthesiology, Westchester Medical Center, Valhalla, USA.
FAU - Gruffi, Catherine
AU  - Gruffi C
AD  - Pediatric Anesthesiology, Westchester Medical Center, Valhalla, USA.
FAU - Overby, Philip
AU  - Overby P
AD  - Pediatric Neurology, Westchester Medical Center, Valhalla, USA.
LA  - eng
PT  - Case Reports
DEP - 20211109
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC8660594
OTO - NOTNLM
OT  - fatty acid oxidation
OT  - lactic acidosis
OT  - mitochondrial disease
OT  - neuromonitoring
OT  - neurosurgery for epilepsy
OT  - propofol infusion syndrome
OT  - rhabdomyolysis
OT  - total intravenous anesthesia
COIS- The authors have declared that no competing interests exist.
EDAT- 2021/12/16 06:00
MHDA- 2021/12/16 06:01
PMCR- 2021/11/09
CRDT- 2021/12/15 12:30
PHST- 2021/11/01 00:00 [accepted]
PHST- 2021/12/15 12:30 [entrez]
PHST- 2021/12/16 06:00 [pubmed]
PHST- 2021/12/16 06:01 [medline]
PHST- 2021/11/09 00:00 [pmc-release]
AID - 10.7759/cureus.19414 [doi]
PST - epublish
SO  - Cureus. 2021 Nov 9;13(11):e19414. doi: 10.7759/cureus.19414. eCollection 2021 
      Nov.