PMID- 34909622
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230206
IS  - 2589-0565 (Electronic)
IS  - 2589-0557 (Print)
IS  - 2589-0557 (Linking)
VI  - 42
IP  - 2
DP  - 2021 Jul-Dec
TI  - A case of primary and secondary syphilis presenting together as immune 
      reconstitution inflammatory syndrome.
PG  - 156-158
LID - 10.4103/ijstd.IJSTD_58_20 [doi]
AB  - Immune reconstitution inflammatory syndrome (IRIS) is a condition during the 
      clinical course of HIV infection in which there is paradoxical worsening and/or 
      new onset of opportunistic infections in a HIV-positive patient who has recently 
      been started on anti-retroviral therapy (ART). We present a case of AIDS with CD4 
      count of 20 cells/mul who presented within 6 weeks of starting ART with a CD4 
      count of 160 cells/mul and a painless solitary genital ulcer along with annular 
      dark-colored plaques over soles. His screening test for syphilis was negative 
      both during baseline evaluation, prior to initiation of ART, and during his 
      clinical presentation. His disease was confirmed based on a positive treponema 
      pallidum hemagglutination test report and a suggestive skin biopsy. He responded 
      well to three doses of Benzathine Penicillin and continuation of ART. There are 
      very few case reports of syphilis presenting as IRIS and this case is all the 
      more unique as he had features of both primary and secondary syphilis occurring 
      together within 6 weeks of starting ART. This report would reiterate the fact 
      that syphilis and HIV co-infection can alter the natural course of both the 
      diseases and a high index of suspicion is required for treating them.
CI  - Copyright: (c) 2021 Indian Journal of Sexually Transmitted Diseases and AIDS.
FAU - Mitra, Debdeep
AU  - Mitra D
AD  - Department of Dermatology, Base Hospital Delhi, Base Hospital Delhi Cantt, New 
      Delhi, India.
FAU - Singh, Gautam Kumar
AU  - Singh GK
AD  - Department of Dermatology, Base Hospital Delhi, Base Hospital Delhi Cantt, New 
      Delhi, India.
FAU - Mitra, Barnali
AU  - Mitra B
AD  - Department of Pediatrics, Base Hospital Delhi, Base Hospital Delhi Cantt, New 
      Delhi, India.
FAU - Talukdar, Krishna
AU  - Talukdar K
AD  - Department of Dermatology, Jorhat Medical College and Hospital, Jorhat, Assam, 
      India.
FAU - Dhillon, Amen
AU  - Dhillon A
AD  - Department of Dermatology, Base Hospital Delhi, Base Hospital Delhi Cantt, New 
      Delhi, India.
FAU - Singh, Tegveer
AU  - Singh T
AD  - Department of Dermatology, Base Hospital Delhi, Base Hospital Delhi Cantt, New 
      Delhi, India.
LA  - eng
PT  - Case Reports
DEP - 20210727
PL  - India
TA  - Indian J Sex Transm Dis AIDS
JT  - Indian journal of sexually transmitted diseases and AIDS
JID - 101730896
CIN - Indian J Sex Transm Dis AIDS. 2022 Jul-Dec;43(2):224-226. PMID: 36743116
PMC - PMC8628094
OTO - NOTNLM
OT  - HIV
OT  - immune reconstitution inflammatory syndrome
OT  - syphilis
COIS- There are no conflicts of interest.
EDAT- 2021/12/16 06:00
MHDA- 2021/12/16 06:01
PMCR- 2021/07/01
CRDT- 2021/12/15 12:33
PHST- 2020/05/20 00:00 [received]
PHST- 2021/01/19 00:00 [revised]
PHST- 2021/02/04 00:00 [accepted]
PHST- 2021/12/15 12:33 [entrez]
PHST- 2021/12/16 06:00 [pubmed]
PHST- 2021/12/16 06:01 [medline]
PHST- 2021/07/01 00:00 [pmc-release]
AID - IJSTD-42-156 [pii]
AID - 10.4103/ijstd.IJSTD_58_20 [doi]
PST - ppublish
SO  - Indian J Sex Transm Dis AIDS. 2021 Jul-Dec;42(2):156-158. doi: 
      10.4103/ijstd.IJSTD_58_20. Epub 2021 Jul 27.