PMID- 34909637
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211217
IS  - 2590-2571 (Electronic)
IS  - 2590-2571 (Linking)
VI  - 1
DP  - 2020 Apr
TI  - Systemic MCPIP1 deficiency in mice impairs lipid homeostasis.
PG  - 1-9
LID - 10.1016/j.crphar.2020.03.001 [doi]
AB  - Atherosclerosis involves interactions between inflammation system and 
      dyslipidemia. MCPIP1 (Monocyte Chemotactic Protein induced Protein-1) is induced 
      by proinflammatory molecules and serves as a negative feedback loop in regulating 
      inflammatory responses. Our current study was designed to test the role of MCPIP1 
      in maintaining lipid homeostasis, the latter a pivotal factor that contributes to 
      the pathogenesis of atherosclerosis. We found that MCPIP1 knockout mice displayed 
      a decrease in levels of serum HDL-cholesterol and total triglycerides but an 
      increase in serum LDL/VLDL-cholesterol levels when compared to wild-type mice. 
      Additionally, ApoA-1 expression was reduced but LPL expression was upregulated in 
      plasma from MCPIP1 knockout mice. The livers from the MCPIP1 knockout mice 
      revealed a decrease in hepatocyte number and an increase in collagen deposition 
      when compared to wild-type mice. These findings suggest that MCPIP1 deficiency 
      can induce liver fibrosis, alter the expression of lipoproteins, and affect 
      transportation and metabolism of lipids, indicating that MCPIP1 is involved in 
      maintaining lipid homeostasis, possibly via negatively regulating inflammatory 
      responses.
CI  - (c) 2020 Published by Elsevier B.V.
FAU - Moody, Joshua
AU  - Moody J
AD  - Department of Pharmacology, A.T. Still University, Kirksville College of 
      Osteopathic Medicine, Kirksville, MO, 63501, USA.
FAU - Yang, Chalen
AU  - Yang C
AD  - Department of Pharmacology, A.T. Still University, Kirksville College of 
      Osteopathic Medicine, Kirksville, MO, 63501, USA.
FAU - Sedinkin, Jessica
AU  - Sedinkin J
AD  - Department of Pharmacology, A.T. Still University, Kirksville College of 
      Osteopathic Medicine, Kirksville, MO, 63501, USA.
FAU - Chang, Yingzi
AU  - Chang Y
AD  - Department of Pharmacology, A.T. Still University, Kirksville College of 
      Osteopathic Medicine, Kirksville, MO, 63501, USA.
LA  - eng
PT  - Journal Article
DEP - 20200506
PL  - Netherlands
TA  - Curr Res Pharmacol Drug Discov
JT  - Current research in pharmacology and drug discovery
JID - 9918300982506676
PMC - PMC8663940
OTO - NOTNLM
OT  - ApoA-1, apoprotein A1
OT  - ApoB-100, apoprotein B100
OT  - Atherosclerosis
OT  - Dyslipidemia
OT  - IL-1 beta , interleukin 1 beta
OT  - IL-6, interleukin 6
OT  - Lipoproteins
OT  - Liver
OT  - MCP-1, monocyte chemoattractant protein 1
OT  - MCPIP1 knockout
OT  - MCPIP1, Monocyte Chemotactic Protein induced Protein-1
OT  - TNF- alpha , Tissue necrosis factor alpha
COIS- None declared.
EDAT- 2020/05/06 00:00
MHDA- 2020/05/06 00:01
PMCR- 2020/05/06
CRDT- 2021/12/15 12:33
PHST- 2020/01/28 00:00 [received]
PHST- 2020/03/05 00:00 [revised]
PHST- 2020/03/05 00:00 [accepted]
PHST- 2021/12/15 12:33 [entrez]
PHST- 2020/05/06 00:00 [pubmed]
PHST- 2020/05/06 00:01 [medline]
PHST- 2020/05/06 00:00 [pmc-release]
AID - S2590-2571(20)30001-8 [pii]
AID - 10.1016/j.crphar.2020.03.001 [doi]
PST - epublish
SO  - Curr Res Pharmacol Drug Discov. 2020 May 6;1:1-9. doi: 
      10.1016/j.crphar.2020.03.001. eCollection 2020 Apr.