PMID- 34910689
OWN - NLM
STAT- MEDLINE
DCOM- 20220131
LR  - 20220131
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 13
IP  - 24
DP  - 2021 Dec 15
TI  - A novel pyroptosis-related gene signature to predict outcomes in laryngeal 
      squamous cell carcinoma.
PG  - 25960-25979
LID - 10.18632/aging.203783 [doi]
AB  - Pyroptosis, a pro-inflammatory form of programmed cell death, is associated with 
      carcinogenesis and progression. However, there is little information concerning 
      pyroptosis-related genes (PRGs) in laryngeal squamous cell carcinoma (LSCC). 
      Herein, we aim to explore the prognostic value of PRGs in LSCC. The expression 
      and clinical data of 47 PRGs in LSCC patients were obtained from The Cancer 
      Genome Atlas. A novel prognostic PRG signature was constructed using least 
      absolute shrinkage and selection operator analysis. Receiver operating 
      characteristic (ROC) curves were drawn, and Kaplan-Meier survival Cox 
      proportional hazard regression analyses were performed to measure the predictive 
      capacity of the PRG signature. Furthermore, we constructed a six-PRG signature to 
      divide LSCC patients into high- and low-risk groups. Patients in the high-risk 
      group had worse overall survival than the low-risk group. The area under the 
      time-dependent ROC curve was 0.696 for 1 year, 0.784 for 3 years, and 0.738 for 5 
      years. We proved that the PRGs signature was an independent predictor for LSCC. 
      Functional enrichment analysis indicated that several immune-related pathways 
      were significantly enriched in the low-risk group. Consistent with this, patients 
      with low-risk scores had higher immune scores and better immunotherapeutic 
      responses than the high-risk group. In conclusion, we established a novel PRGs 
      signature that can predict outcome and response to immunotherapy of LSCC, 
      pyroptosis may be a potential target for LSCC.
FAU - Zhou, Chongchang
AU  - Zhou C
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Medical Center 
      Lihuili Hospital, Ningbo 315040, Zhejiang, China.
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Lihuili Hospital 
      Affiliated to Ningbo University, Ningbo 315040, Zhejiang, China.
FAU - Zhan, Guowen
AU  - Zhan G
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Yinzhou Second 
      Hospital, Ningbo 315040, Zhejiang, China.
FAU - Jin, Yangli
AU  - Jin Y
AD  - Department of Ultrasonography, Ningbo Yinzhou Second Hospital, Ningbo 315040, 
      Zhejiang, China.
FAU - Chen, Jianneng
AU  - Chen J
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Zhenhai Longsai 
      Hospital, Ningbo 315200, Zhejiang, China.
FAU - Shen, Zhisen
AU  - Shen Z
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Medical Center 
      Lihuili Hospital, Ningbo 315040, Zhejiang, China.
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Lihuili Hospital 
      Affiliated to Ningbo University, Ningbo 315040, Zhejiang, China.
FAU - Shen, Yi
AU  - Shen Y
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Medical Center 
      Lihuili Hospital, Ningbo 315040, Zhejiang, China.
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Lihuili Hospital 
      Affiliated to Ningbo University, Ningbo 315040, Zhejiang, China.
FAU - Deng, Hongxia
AU  - Deng H
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Medical Center 
      Lihuili Hospital, Ningbo 315040, Zhejiang, China.
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Lihuili Hospital 
      Affiliated to Ningbo University, Ningbo 315040, Zhejiang, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211215
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
SB  - IM
MH  - Carcinoma, Squamous Cell/*genetics
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics
MH  - Models, Statistical
MH  - *Outcome Assessment, Health Care
MH  - Pyroptosis/*genetics
MH  - Risk Factors
PMC - PMC8751611
OTO - NOTNLM
OT  - LSCC
OT  - immune microenvironment
OT  - immunotherapy
OT  - outcome
OT  - pyroptosis
COIS- CONFLICTS OF INTEREST: The authors declare there are no financial or other 
      conflicts of interest associated with this study.
EDAT- 2021/12/16 06:00
MHDA- 2022/02/01 06:00
PMCR- 2021/12/31
CRDT- 2021/12/15 17:16
PHST- 2021/08/28 00:00 [received]
PHST- 2021/12/02 00:00 [accepted]
PHST- 2021/12/16 06:00 [pubmed]
PHST- 2022/02/01 06:00 [medline]
PHST- 2021/12/15 17:16 [entrez]
PHST- 2021/12/31 00:00 [pmc-release]
AID - 203783 [pii]
AID - 10.18632/aging.203783 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2021 Dec 15;13(24):25960-25979. doi: 10.18632/aging.203783. 
      Epub 2021 Dec 15.