PMID- 34910930
OWN - NLM
STAT- MEDLINE
DCOM- 20220222
LR  - 20240510
IS  - 1097-4180 (Electronic)
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 55
IP  - 1
DP  - 2022 Jan 11
TI  - Epithelial colonization by gut dendritic cells promotes their functional 
      diversification.
PG  - 129-144.e8
LID - S1074-7613(21)00499-4 [pii]
LID - 10.1016/j.immuni.2021.11.008 [doi]
AB  - Dendritic cells (DCs) patrol tissues and transport antigens to lymph nodes to 
      initiate adaptive immune responses. Within tissues, DCs constitute a complex cell 
      population composed of distinct subsets that can exhibit different activation 
      states and functions. How tissue-specific cues orchestrate DC diversification 
      remains elusive. Here, we show that the small intestine included two pools of 
      cDC2s originating from common pre-DC precursors: (1) lamina propria (LP) 
      CD103(+)CD11b(+) cDC2s that were mature-like proinflammatory cells and (2) 
      intraepithelial cDC2s that exhibited an immature-like phenotype as well as 
      tolerogenic properties. These phenotypes resulted from the action of food-derived 
      retinoic acid (ATRA), which enhanced actomyosin contractility and promoted LP 
      cDC2 transmigration into the epithelium. There, cDC2s were imprinted by 
      environmental cues, including ATRA itself and the mucus component Muc2. Hence, by 
      reaching distinct subtissular niches, DCs can exist as immature and mature cells 
      within the same tissue, revealing an additional mechanism of DC functional 
      diversification.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Rivera, Claudia A
AU  - Rivera CA
AD  - Institut Curie, INSERM U932, PSL Research University, 75005 Paris, France.
FAU - Randrian, Violaine
AU  - Randrian V
AD  - Institut Curie, INSERM U932, PSL Research University, 75005 Paris, France.
FAU - Richer, Wilfrid
AU  - Richer W
AD  - Institut Curie, INSERM U932, PSL Research University, 75005 Paris, France.
FAU - Gerber-Ferder, Yohan
AU  - Gerber-Ferder Y
AD  - Institut Curie, INSERM U932, PSL Research University, 75005 Paris, France.
FAU - Delgado, Maria-Graciela
AU  - Delgado MG
AD  - Institut Curie, INSERM U932, PSL Research University, 75005 Paris, France.
FAU - Chikina, Aleksandra S
AU  - Chikina AS
AD  - Institut Curie, INSERM U932, PSL Research University, 75005 Paris, France; 
      Institut Curie, CNRS UMR 144, PSL Research University, 75005 Paris, France.
FAU - Frede, Annika
AU  - Frede A
AD  - Immunology and Allergy division, Department of Medicine, Solna, Karolinska 
      Institutet and University Hospital, 17176 Stockholm, Sweden; Center of Molecular 
      Medicine, 17176 Stockholm, Sweden.
FAU - Sorini, Chiara
AU  - Sorini C
AD  - Immunology and Allergy division, Department of Medicine, Solna, Karolinska 
      Institutet and University Hospital, 17176 Stockholm, Sweden; Center of Molecular 
      Medicine, 17176 Stockholm, Sweden.
FAU - Maurin, Mathieu
AU  - Maurin M
AD  - Institut Curie, INSERM U932, PSL Research University, 75005 Paris, France.
FAU - Kammoun-Chaari, Hana
AU  - Kammoun-Chaari H
AD  - Biology of Infection Unit, Institut Pasteur, INSERM U1117, 75015 Paris, France.
FAU - Parigi, Sara M
AU  - Parigi SM
AD  - Immunology and Allergy division, Department of Medicine, Solna, Karolinska 
      Institutet and University Hospital, 17176 Stockholm, Sweden; Center of Molecular 
      Medicine, 17176 Stockholm, Sweden.
FAU - Goudot, Christel
AU  - Goudot C
AD  - Institut Curie, INSERM U932, PSL Research University, 75005 Paris, France.
FAU - Cabeza-Cabrerizo, Mar
AU  - Cabeza-Cabrerizo M
AD  - Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
FAU - Baulande, Sylvain
AU  - Baulande S
AD  - ICGex Next-Generation Sequencing Platform, Institut Curie, PSL Research 
      University, 75005 Paris, France.
FAU - Lameiras, Sonia
AU  - Lameiras S
AD  - ICGex Next-Generation Sequencing Platform, Institut Curie, PSL Research 
      University, 75005 Paris, France.
FAU - Guermonprez, Pierre
AU  - Guermonprez P
AD  - Universite de Paris, Centre for Inflammation Research, CNRS ERL8252, INSERM1149, 
      Paris, France.
FAU - Reis e Sousa, Caetano
AU  - Reis e Sousa C
AD  - Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
FAU - Lecuit, Marc
AU  - Lecuit M
AD  - Biology of Infection Unit, Institut Pasteur, INSERM U1117, 75015 Paris, France; 
      Universite de Paris, Necker-Enfants Malades University Hospital, Department of 
      Infectious Diseases and Tropical Medicine, APHP, Institut Imagine, Paris, France.
FAU - Moreau, Helene D
AU  - Moreau HD
AD  - Institut Curie, INSERM U932, PSL Research University, 75005 Paris, France.
FAU - Helft, Julie
AU  - Helft J
AD  - Institut Curie, INSERM U932, PSL Research University, 75005 Paris, France.
FAU - Vignjevic, Danijela Matic
AU  - Vignjevic DM
AD  - Institut Curie, CNRS UMR 144, PSL Research University, 75005 Paris, France.
FAU - Villablanca, Eduardo J
AU  - Villablanca EJ
AD  - Immunology and Allergy division, Department of Medicine, Solna, Karolinska 
      Institutet and University Hospital, 17176 Stockholm, Sweden; Center of Molecular 
      Medicine, 17176 Stockholm, Sweden.
FAU - Lennon-Dumenil, Ana-Maria
AU  - Lennon-Dumenil AM
AD  - Institut Curie, INSERM U932, PSL Research University, 75005 Paris, France. 
      Electronic address: amlennon@curie.fr.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 22369/CRUK_/Cancer Research UK/United Kingdom
GR  - FC001136/ARC_/Arthritis Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211214
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Antigens, CD)
RN  - 0 (CD11b Antigen)
RN  - 0 (Integrin alpha Chains)
RN  - 0 (MUC2 protein, human)
RN  - 0 (Mucin-2)
RN  - 0 (alpha E integrins)
RN  - 5688UTC01R (Tretinoin)
RN  - 9013-26-7 (Actomyosin)
SB  - IM
MH  - Actomyosin/metabolism
MH  - Animals
MH  - Antigen Presentation
MH  - Antigens, CD/metabolism
MH  - CD11b Antigen/metabolism
MH  - Cell Differentiation
MH  - Cell Movement
MH  - Cells, Cultured
MH  - Dendritic Cells/*immunology
MH  - Immune Tolerance
MH  - Inflammation/*immunology
MH  - Integrin alpha Chains/metabolism
MH  - Intestinal Mucosa/*pathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Mucin-2/immunology
MH  - T-Lymphocytes/*immunology
MH  - Tretinoin/metabolism
PMC - PMC8751639
OTO - NOTNLM
OT  - T cell activation and tolerance
OT  - antigen presentation
OT  - epithelium
OT  - immature and mature dendritic cells
OT  - niche
OT  - small intestine
OT  - transmigration
COIS- Declaration of interests C.R.S. has an additional appointment as professor in the 
      Faculty of Medicine at Imperial College London. C.R.S. is a founder of Adendra 
      Therapeutics and owns stock options and/or is a paid consultant for Adendra 
      Therapeutics, Bicara Therapeutics, Montis Biosciences, Oncurious NV, Bicycle 
      Therapeutics, and Sosei Heptares, all unrelated to this work.
EDAT- 2021/12/16 06:00
MHDA- 2022/02/23 06:00
PMCR- 2022/01/11
CRDT- 2021/12/15 20:08
PHST- 2021/06/15 00:00 [received]
PHST- 2021/08/19 00:00 [revised]
PHST- 2021/11/15 00:00 [accepted]
PHST- 2021/12/16 06:00 [pubmed]
PHST- 2022/02/23 06:00 [medline]
PHST- 2021/12/15 20:08 [entrez]
PHST- 2022/01/11 00:00 [pmc-release]
AID - S1074-7613(21)00499-4 [pii]
AID - 10.1016/j.immuni.2021.11.008 [doi]
PST - ppublish
SO  - Immunity. 2022 Jan 11;55(1):129-144.e8. doi: 10.1016/j.immuni.2021.11.008. Epub 
      2021 Dec 14.