PMID- 34911030
OWN - NLM
STAT- MEDLINE
DCOM- 20220323
LR  - 20220323
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 102
DP  - 2022 Jan
TI  - Association between exposure to chemical mixtures in relation to serum total IgE 
      among adults 19-86 years old.
PG  - 108428
LID - S1567-5769(21)01064-X [pii]
LID - 10.1016/j.intimp.2021.108428 [doi]
AB  - There is a scarcity of studies on the effects of mixed chemicals on total IgE. We 
      aim to assess whether there is a link between chemical mixtures (blood and urine 
      of 26 chemicals including lead, mercury, cadmium, t,t-muconic acid, 
      benzylmercapturic acid , 1-hydroxypyrene, 2-naphthol, 2-hydroxyfluorene, 
      1-hydroxyphenanthrene, mono-(2-ethyl-5-hydroxyhexyl) phthalate, 
      mono-(2-ethyl-5-oxohexyl) phthalate, mono-n-butyl phthalate, mono-benzyl 
      phthalate, mono-(2-ethyl-5-carboxypentyl) phthalate, mono-carboxyoctyl phthalate, 
      mono-carboxy-isononly phthalate, mono (3-carboxypropyl) phthalate, bisphenol A, 
      bisphenol F, bisphenol S, triclosan, methylparaben, ethylparaben, propylparaben, 
      3-phenoxybenzoic acid, and cotinine), and total IgE in 3,642 Korean adults 
      aged >/= 19. The effects of mixed chemical exposure on total IgE were identified 
      using linear regression models, weighted quantile sum (WQS) regression, quantile 
      g-computation (qgcomp), and Bayesian kernel machine regression (BKMR). The most 
      relevant factors linked with IgE, according to the linear regression models, were 
      blood or urine mercury and urine bisphenol A levels, with significant trends 
      detected for these chemical tertiles (p < 0.01). The WQS index was significantly 
      linked with ln2-transformed levels of serum total IgE (beta = 0.30, 95 %CI 
      0.25-0.32). The qgcomp index also found a significant link between chemicals and 
      ln2-transformed levels of serum total IgE (beta = 0.52, 95 %CI 0.21-0.82), and 
      elevated serum total IgE levels (OR = 2.55, 95 %CI 1.14-5.71). In BKMR analysis, 
      the overall effect of the mixture was significantly associated with 
      ln2-transformed levels of serum total IgE. The cutoff levels for exposure levels 
      related to serum total IgE levels/elevated serum total IgE levels were reported. 
      We discovered that whole-body exposure to 26 chemicals was associated with serum 
      total IgE levels after assessing the findings of these four models. More research 
      is needed in the future to gain a better understanding of the impact of mixed 
      chemical exposure on allergic disorders and how to minimize chemical exposure, 
      especially for people under the age of 18.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Duc Nguyen, Hai
AU  - Duc Nguyen H
AD  - Department of Pharmacy, College of Pharmacy and Research Institute of Life and 
      Pharmaceutical Sciences, Sunchon National University, Sunchon, Jeonnam, Republic 
      of Korea.
FAU - Oh, Hojin
AU  - Oh H
AD  - Department of Pharmacy, College of Pharmacy and Research Institute of Life and 
      Pharmaceutical Sciences, Sunchon National University, Sunchon, Jeonnam, Republic 
      of Korea.
FAU - Kim, Min-Sun
AU  - Kim MS
AD  - Department of Pharmacy, College of Pharmacy and Research Institute of Life and 
      Pharmaceutical Sciences, Sunchon National University, Sunchon, Jeonnam, Republic 
      of Korea. Electronic address: minsun@scnu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20211212
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Environmental Pollutants)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Environmental Exposure/*adverse effects
MH  - Environmental Pollutants/*adverse effects
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - Young Adult
OTO - NOTNLM
OT  - Allergic disorders
OT  - Bayesian kernel machine regression
OT  - Chemical mixture
OT  - Modeling
OT  - Threshold
OT  - Total serum IgE
EDAT- 2021/12/16 06:00
MHDA- 2022/03/24 06:00
CRDT- 2021/12/15 20:13
PHST- 2021/10/25 00:00 [received]
PHST- 2021/11/20 00:00 [revised]
PHST- 2021/11/30 00:00 [accepted]
PHST- 2021/12/16 06:00 [pubmed]
PHST- 2022/03/24 06:00 [medline]
PHST- 2021/12/15 20:13 [entrez]
AID - S1567-5769(21)01064-X [pii]
AID - 10.1016/j.intimp.2021.108428 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2022 Jan;102:108428. doi: 10.1016/j.intimp.2021.108428. Epub 
      2021 Dec 12.