PMID- 34911084
OWN - NLM
STAT- MEDLINE
DCOM- 20220719
LR  - 20220719
IS  - 1439-3646 (Electronic)
IS  - 0947-7349 (Linking)
VI  - 130
IP  - 7
DP  - 2022 Jul
TI  - A Risk Assessment Tool for Identifying Osteoporosis in Older Women with Type 2 
      Diabetes Mellitus.
PG  - 426-433
LID - 10.1055/a-1702-5168 [doi]
AB  - PURPOSE: To develop a simple and clinically useful assessment tool for 
      osteoporosis in older women with type 2 diabetes mellitus (T2DM). METHODS: A 
      total of 601 women over 60 years of age with T2DM were enrolled in this study. 
      The levels of serum sex hormones and bone metabolism markers were compared 
      between the osteoporosis and non-osteoporosis groups. The least absolute 
      shrinkage and selection operator regularization (LASSO) model was applied to 
      generate a risk assessment tool. The risk score formula was evaluated using 
      receiver operating characteristic analysis and the relationship between the risk 
      score and the bone mineral density (BMD) and T-value were investigated. RESULTS: 
      Serum sex hormone-binding globulin (SHBG), cross-linked C-telopeptide of type 1 
      collagen (CTX), and osteocalcin (OC) were significantly higher in the 
      osteoporosis group. After adjustment for age and body mass index (BMI), SHBG was 
      found to be correlated with the T-value or BMD. Then, a risk score was 
      specifically generated with age, BMI, SHBG, and CTX using the LASSO model. The 
      risk score was significantly negatively correlated with the T-value and BMD of 
      the lumbar spine, femoral neck, and total hip (all P<0.05). CONCLUSION: A risk 
      score using age, BMI, SHBG, and CTX performs well for identifying osteoporosis in 
      older women with T2DM.
CI  - Thieme. All rights reserved.
FAU - Pan, Fenghui
AU  - Pan F
AD  - Division of Geriatrics, Nanjing Drum Tower Hospital, The Affiliated Hospital of 
      Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
FAU - Cui, Wenxia
AU  - Cui W
AD  - Division of Geriatrics, Nanjing Drum Tower Hospital, The Affiliated Hospital of 
      Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
FAU - Gao, Lei
AU  - Gao L
AD  - Division of Geriatrics, Nanjing Drum Tower Hospital, The Affiliated Hospital of 
      Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
FAU - Shi, Xiaoting
AU  - Shi X
AD  - Division of Geriatrics, Nanjing Drum Tower Hospital, The Affiliated Hospital of 
      Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
FAU - Zhang, Mingrui
AU  - Zhang M
AD  - Division of Geriatrics, Nanjing Drum Tower Hospital, The Affiliated Hospital of 
      Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
FAU - Li, Man
AU  - Li M
AD  - Division of Geriatrics, Nanjing Drum Tower Hospital, The Affiliated Hospital of 
      Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
FAU - Yang, Haiyan
AU  - Yang H
AD  - Division of Geriatrics, Nanjing Drum Tower Hospital, The Affiliated Hospital of 
      Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
FAU - Hu, Yun
AU  - Hu Y
AD  - Division of Geriatrics, Nanjing Drum Tower Hospital, The Affiliated Hospital of 
      Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
LA  - eng
PT  - Journal Article
DEP - 20211215
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German 
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
RN  - 0 (Biomarkers)
RN  - 0 (Collagen Type I)
RN  - 104982-03-8 (Osteocalcin)
SB  - IM
MH  - Absorptiometry, Photon
MH  - Aged
MH  - Biomarkers
MH  - Bone Density
MH  - Collagen Type I
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Osteocalcin
MH  - *Osteoporosis
MH  - Risk Assessment
COIS- The authors declare that they have no conflict of interest.
EDAT- 2021/12/16 06:00
MHDA- 2022/07/20 06:00
CRDT- 2021/12/15 20:14
PHST- 2021/12/16 06:00 [pubmed]
PHST- 2022/07/20 06:00 [medline]
PHST- 2021/12/15 20:14 [entrez]
AID - 10.1055/a-1702-5168 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2022 Jul;130(7):426-433. doi: 10.1055/a-1702-5168. 
      Epub 2021 Dec 15.