PMID- 34911838
OWN - NLM
STAT- MEDLINE
DCOM- 20211217
LR  - 20240321
IS  - 1672-7347 (Print)
IS  - 1672-7347 (Linking)
VI  - 46
IP  - 10
DP  - 2021 Oct 28
TI  - Abnormal neurobiochemical metabolites in the first- episode schizophrenia and 
      clinical high-risk population.
PG  - 1090-1095
LID - 1672-7347(2021)10-1090-06 [pii]
LID - 10.11817/j.issn.1672-7347.2021.200240 [doi]
AB  - OBJECTIVES: To explore the metabolite characteristics in medial prefrontal cortex 
      (mPFC) by (1)H magnetic resonance spectroscopy ((1)H-MRS) in the first-episode 
      schizophrenia (FES) and clinical high-risk (CHR) people. METHODS: A total of 46 
      patients with the first-episode schizophrenia (FES), 49 people with clinical high 
      risk (CHR), 61 people with genetic high risk (GHR), and 58 healthy controls (HC) 
      were enrolled. The levels of N-acetylaspartylglutamate+N-acetylaspartate (tNAA), 
      choline-containing compounds (Cho) and myo-inositol (MI), glutamate+glutamine 
      (Glx) in medial prefrontal cortex were measured by single-voxel (1)H-MRS. The 
      clinical symptoms were evaluated in the FES group and the CHR group. Continuous 
      performance test (CPT) were carried out to assess the visual and auditory 
      accuracy and reaction time in the 4 groups. RESULTS: There were significant 
      differences in Glx, tNAA, and MI concentrations among 4 groups (all P<0.05). 
      Compared with the HC group, the FES group showed lower level of MI and Glx. The 
      levels of Glx and tNAA in the CHR group were significantly lower than those in 
      the GHR group (all P<0.05). The visual and auditory accuracies of CPT in the FES 
      group were significantly lower than those in the HC group (P<0.05). In the FES 
      group, Glx was negatively correlated with the reaction time of vision (r=-0.41, 
      P=0.05). CONCLUSIONS: The decreased levels of MI and Glx in the FES patients 
      suggest that there may be glial functional damage and glutamatergic transmitter 
      dysfunction in the early stage of the disease. The compensatory increase of 
      metabolites may be a protective factor for schizophrenia in the genetic 
      individuals.
FAU - Ouyang, Lijun
AU  - Ouyang L
AD  - Mental Health Institute, Second Xiangya Hospital, Central South University; China 
      National Technology Institute on Mental Disorders; National Technology Institute 
      on Mental Disorders; Hunan Key Laboratory of Psychiatry and Mental Health; Hunan 
      Medical Center for Mental Health, Changsha 410011, China. lijunouyang@csu.edu.cn.
FAU - Zheng, Wenxiao
AU  - Zheng W
AD  - Mental Health Institute, Second Xiangya Hospital, Central South University; China 
      National Technology Institute on Mental Disorders; National Technology Institute 
      on Mental Disorders; Hunan Key Laboratory of Psychiatry and Mental Health; Hunan 
      Medical Center for Mental Health, Changsha 410011, China.
FAU - Ma, Xiaoqian
AU  - Ma X
AD  - Mental Health Institute, Second Xiangya Hospital, Central South University; China 
      National Technology Institute on Mental Disorders; National Technology Institute 
      on Mental Disorders; Hunan Key Laboratory of Psychiatry and Mental Health; Hunan 
      Medical Center for Mental Health, Changsha 410011, China.
FAU - Yuan, Liu
AU  - Yuan L
AD  - Mental Health Institute, Second Xiangya Hospital, Central South University; China 
      National Technology Institute on Mental Disorders; National Technology Institute 
      on Mental Disorders; Hunan Key Laboratory of Psychiatry and Mental Health; Hunan 
      Medical Center for Mental Health, Changsha 410011, China.
FAU - He, Ying
AU  - He Y
AD  - Mental Health Institute, Second Xiangya Hospital, Central South University; China 
      National Technology Institute on Mental Disorders; National Technology Institute 
      on Mental Disorders; Hunan Key Laboratory of Psychiatry and Mental Health; Hunan 
      Medical Center for Mental Health, Changsha 410011, China. yinghe@csu.edu.cn.
FAU - Chen, Xiaogang
AU  - Chen X
AD  - Mental Health Institute, Second Xiangya Hospital, Central South University; China 
      National Technology Institute on Mental Disorders; National Technology Institute 
      on Mental Disorders; Hunan Key Laboratory of Psychiatry and Mental Health; Hunan 
      Medical Center for Mental Health, Changsha 410011, China. 
      Chenxiaogang@csu.edu.cn.
LA  - eng
LA  - chi
GR  - 81871056/the National Natural Science Foundation of China/
PT  - Journal Article
TT  - 首发精神分裂症及临床高危人群脑神经生化代谢物异常.
PL  - China
TA  - Zhong Nan Da Xue Xue Bao Yi Xue Ban
JT  - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. 
      Medical sciences
JID - 101230586
RN  - 0RH81L854J (Glutamine)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
MH  - Aspartic Acid
MH  - Glutamic Acid
MH  - Glutamine
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Magnetic Resonance Spectroscopy
MH  - Proton Magnetic Resonance Spectroscopy
MH  - *Schizophrenia
PMC - PMC10930238
OAB - OBJECTIVE: To explore the metabolite characteristics in medial prefrontal cortex 
      (mPFC) by (1)H magnetic resonance spectroscopy ((1)H-MRS) in the first-episode 
      schizophrenia (FES) and clinical high-risk (CHR) people. METHODS: A total of 46 
      patients with the first-episode schizophrenia (FES), 49 people with clinical high 
      risk (CHR), 61 people with genetic high risk (GHR), and 58 healthy controls (HC) 
      were enrolled. The levels of N-acetylaspartylglutamate+N-acetylaspartate (tNAA), 
      choline-containing compounds (Cho) and myo-inositol (MI), glutamate+glutamine 
      (Glx) in medial prefrontal cortex were measured by single-voxel (1)H-MRS. The 
      clinical symptoms were evaluated in the FES group and the CHR group. Continuous 
      performance test (CPT) were carried out to assess the visual and auditory 
      accuracy and reaction time in the 4 groups. RESULTS: There were significant 
      differences in Glx, tNAA, and MI concentrations among 4 groups (all P<0.05). 
      Compared with the HC group, the FES group showed lower level of MI and Glx. The 
      levels of Glx and tNAA in the CHR group were significantly lower than those in 
      the GHR group (all P<0.05). The visual and auditory accuracies of CPT in the FES 
      group were significantly lower than those in the HC group (P<0.05). In the FES 
      group, Glx was negatively correlated with the reaction time of vision (r=-0.41, 
      P=0.05). CONCLUSION: The decreased levels of MI and Glx in the FES patients 
      suggest that there may be glial functional damage and glutamatergic transmitter 
      dysfunction in the early stage of the disease. The compensatory increase of 
      metabolites may be a protective factor for schizophrenia in the genetic 
      individuals.
OABL- eng
OTO - NOTNLM
OT  - first-episode schizophrenia
OT  - high-risk population
OT  - magnetic resonance spectroscopy
COIS- 作者声称无任何利益冲突。
EDAT- 2021/12/17 06:00
MHDA- 2021/12/18 06:00
PMCR- 2021/10/28
CRDT- 2021/12/16 05:53
PHST- 2021/12/16 05:53 [entrez]
PHST- 2021/12/17 06:00 [pubmed]
PHST- 2021/12/18 06:00 [medline]
PHST- 2021/10/28 00:00 [pmc-release]
AID - 1672-7347(2021)10-1090-06 [pii]
AID - 10.11817/j.issn.1672-7347.2021.200240 [doi]
PST - ppublish
SO  - Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2021 Oct 28;46(10):1090-1095. doi: 
      10.11817/j.issn.1672-7347.2021.200240.