PMID- 34912392
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220429
IS  - 1682-024X (Print)
IS  - 1681-715X (Electronic)
IS  - 1681-715X (Linking)
VI  - 37
IP  - 7
DP  - 2021 Nov-Dec
TI  - Correlation of Serum Vaspin, Omentin-1, and adiponectin with metabolic phenotypes 
      in Type-2 diabetes mellitus patients.
PG  - 1762-1767
LID - 10.12669/pjms.37.7.4330 [doi]
AB  - OBJECTIVES: To investigate adipocytokines' (vaspin, omentin-1, and adiponectin) 
      correlation with metabolic phenotypes in type 2 diabetes mellitus (T2DM) 
      patients. METHODS: This case-control research was done at the Diabetic Clinic in 
      Jeddah, Kingdom of Saudi Arabia (KSA), from November 2018 to March 2019. 
      Seventy-five T2DM patients and 75 gender, age, and BMI-matched healthy subjects 
      were recruited for this research. RESULTS: In DM patients, the concentrations of 
      serum vaspin and omentin-1 were substantially lower (p<0.001) than in the control 
      group. A significant positive relationship between vaspin concentration and DBP 
      (p<0.001), BMI (p<0.001), and waist circumference (p<0.001) was found in patients 
      and control subjects, while FPG (p<0.016), serum insulin (p<0.001), HOMA-IR 
      (p<0.001), TC (p<0.001), TG (p<0.001), and LDLc (p<0.001) were significantly 
      interrelated among patients. Serum concentrations of omentin-1 and ADN were 
      significantly negatively correlated with serum insulin, HOMA-IR, and TG among the 
      DM group. Serum vaspin and ADN levels were significantly higher in the cases and 
      control groups with BMI>25, and no gender-wise variance was observed in 
      adipocytokines levels. Binary logistic regression analysis showed a significantly 
      negative predictive relationship of vaspin and omentin-1 with DM. CONCLUSION: The 
      DM group displayed substantially lower serum vaspin and omentin-1 levels. 
      However, there was no consistent relationship observed between these 
      adipocytokines and metabolic phenotypes.
CI  - Copyright: (c) Pakistan Journal of Medical Sciences.
FAU - Baig, Mukhtiar
AU  - Baig M
AD  - Dr. Mukhtiar Baig, Ph.D. Department of Clinical Biochemistry, Faculty of 
      Medicine, Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia.
FAU - Gazzaz, Zohair J
AU  - Gazzaz ZJ
AD  - Dr. Zohair J Gazzaz, Ph.D. Department of Internal Medicine, Faculty of Medicine, 
      Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia.
FAU - Bakarman, Marwan A
AU  - Bakarman MA
AD  - Dr. Marwan A Bakarman, FFCM. Department of Family and Community Medicine, Faculty 
      of Medicine, Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia.
FAU - Alzahrani, Sami H
AU  - Alzahrani SH
AD  - Dr. Sami H Alzahrani, SBFM Department of Family Medicine, Faculty of Medicine, 
      King Abdulaziz University, Jeddah, Saudi Arabia.
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - Pak J Med Sci
JT  - Pakistan journal of medical sciences
JID - 100913117
PMC - PMC8613014
OTO - NOTNLM
OT  - Adipokines
OT  - Adiponectin
OT  - Diabetes Mellitus
OT  - Omentin-1
OT  - Vaspin
EDAT- 2021/12/17 06:00
MHDA- 2021/12/17 06:01
PMCR- 2021/11/01
CRDT- 2021/12/16 06:31
PHST- 2021/02/24 00:00 [received]
PHST- 2021/05/29 00:00 [revised]
PHST- 2021/06/15 00:00 [accepted]
PHST- 2021/12/16 06:31 [entrez]
PHST- 2021/12/17 06:00 [pubmed]
PHST- 2021/12/17 06:01 [medline]
PHST- 2021/11/01 00:00 [pmc-release]
AID - PJMS-37-1762 [pii]
AID - 10.12669/pjms.37.7.4330 [doi]
PST - ppublish
SO  - Pak J Med Sci. 2021 Nov-Dec;37(7):1762-1767. doi: 10.12669/pjms.37.7.4330.