PMID- 34912408
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220429
IS  - 1682-024X (Print)
IS  - 1681-715X (Electronic)
IS  - 1681-715X (Linking)
VI  - 37
IP  - 7
DP  - 2021 Nov-Dec
TI  - Changes of Serum Ficolin-3 and C5b-9 in Patients with Heart Failure.
PG  - 1860-1864
LID - 10.12669/pjms.37.7.4151 [doi]
AB  - OBJECTIVES: To investigate the correlation of serum ficolin-3 and C5b-9 with 
      cardiac function and NT-proBNP in patients with heart failure. METHODS: Sixty 
      patients with heart failure admitted to the Baoding First Central Hospital from 
      May 2019 to May 2020 were selected and divided into three groups according to the 
      classification of New York Heart Association (NYHA). Patients with NYHA grade II, 
      III, and IV were included into group A, B, and C, respectively. Among the 
      population undergoing physical examination at the same time, 20 cases with no 
      significant difference in age and gender from the experimental group were 
      selected as the control group (Group-N), and their clinical data were recorded. 
      The serum levels of ficolin-3, C5b-9 and NT-proBNP in each group were detected 
      and compared. RESULTS: The serum concentrations of ficolin-3 and C5b-9 in Group N 
      were significantly different from those in Group A, B and C (p<0.05), the 
      difference between Group C and Group A and B was statistically significant 
      (p<0.05), there was no significant difference between group A and B (p>0.05). The 
      correlation analysis between serum ficolin-3 and NT-proBNP showed that serum 
      ficolin-3 was negatively correlated with NT-proBNP (r=-0.606, p<0.0001), while 
      the correlation analysis between serum C5b-9 and NT-proBNP showed that serum 
      C5b-9 was positively correlated with NT-proBNP (r=0.499, p<0.0001). According to 
      the etiology of heart failure, patients with heart failure were divided into 
      coronary heart disease (25 cases), dilated cardiomyopathy (15 cases) and others 
      (20 cases). The differences of ficolin-3 and C5b-9 among patients were compared, 
      and there was no statistical difference (p<0.05). CONCLUSION: Ficolin-3 was 
      inversely associated with the severity of heart failure, while C5b-9 was 
      positively associated with the severity of cardiac impairment. Both of them have 
      nothing to do with the etiology of heart failure.
CI  - Copyright: (c) Pakistan Journal of Medical Sciences.
FAU - Li, Hongli
AU  - Li H
AD  - Hongli Li, Department of Cardiology, Baoding First Central Hospital, Baoding, 
      Hebei 071000, China.
FAU - Zhang, Fangfang
AU  - Zhang F
AD  - Fangfang Zhang, Department of Cardiology, Baoding First Central Hospital, 
      Baoding, Hebei 071000, China.
FAU - Zhang, Dan
AU  - Zhang D
AD  - Dan Zhang, Department of Cardiology, Baoding First Central Hospital, Baoding, 
      Hebei 071000, China.
FAU - Tian, Xiang
AU  - Tian X
AD  - Xiang Tian, Department of Cardiology, Baoding First Central Hospital, Baoding, 
      Hebei 071000, China.
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - Pak J Med Sci
JT  - Pakistan journal of medical sciences
JID - 100913117
PMC - PMC8613035
OTO - NOTNLM
OT  - C5b-9
OT  - Ficolin-3
OT  - Heart failure
COIS- Declaration of conflicting interest: None
EDAT- 2021/12/17 06:00
MHDA- 2021/12/17 06:01
PMCR- 2021/11/01
CRDT- 2021/12/16 06:31
PHST- 2021/01/12 00:00 [received]
PHST- 2021/07/12 00:00 [revised]
PHST- 2021/07/19 00:00 [revised]
PHST- 2021/07/25 00:00 [accepted]
PHST- 2021/12/16 06:31 [entrez]
PHST- 2021/12/17 06:00 [pubmed]
PHST- 2021/12/17 06:01 [medline]
PHST- 2021/11/01 00:00 [pmc-release]
AID - PJMS-37-1860 [pii]
AID - 10.12669/pjms.37.7.4151 [doi]
PST - ppublish
SO  - Pak J Med Sci. 2021 Nov-Dec;37(7):1860-1864. doi: 10.12669/pjms.37.7.4151.