PMID- 34912508
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220429
IS  - 2008-7802 (Print)
IS  - 2008-8213 (Electronic)
IS  - 2008-7802 (Linking)
VI  - 12
DP  - 2021
TI  - Subcutaneous Adipose Tissue Browning, Serum Orexin-A, and Insulin Resistance 
      Following Aerobic Exercise in High-Fat Diet Obesity Male Wistar Rats.
PG  - 132
LID - 10.4103/ijpvm.IJPVM_110_19 [doi]
LID - 132
AB  - BACKGROUND: Subcutaneous adipose tissue (SAT) relative to the other adipose 
      tissues may have different roles in health and insulin resistance. The purpose of 
      this study was to investigate the effectiveness of aerobic exercise on SAT 
      thermogenesis indices, serum orexin-A (OXA), and insulin resistance in high-fat 
      diet-induced obesity male Wistar rats. METHODS: Thirty-two male Wistar rats with 
      an average weight of 180-200 g were randomly assigned into 4 equal groups: normal 
      fat diet (NFD), high-fat diet obesity (HFDO), normal fat diet after high-fat diet 
      obesity (HFDO-NFD), and aerobic exercise group with normal fat diet after 
      high-fat diet obesity (HFDO-AEX). Fasting levels of serum OXA, insulin, FBS, 
      high-density lipoproteins, low-density lipoproteins, cholesterol and gene 
      expression of peroxisome proliferator-activated receptor gamma coactivator 
      1-alpha (PGC-1alpha) and UCP1 in SAT were evaluated. Samples were taken in the HFDO 
      group after obesity-induced and in other groups 48 h after 8 weeks of aerobic 
      exercise. RESULTS: The results showed that HFD significantly decreased serum 
      levels of OXA, HDL-c and gene expression of PGC1alpha and UCP1 in SAT. In addition, 
      it caused a significant increase in Lee index, FBS, insulin resistance, and serum 
      lipid profile in comparison with the NFD group (P </= 0.001). Aerobic exercise 
      significantly modified the changes caused by HFD to the normal levels (P </= 
      0.001). CONCLUSIONS: These data suggest that aerobic exercise caused an 
      improvement in insulin resistance and blood lipid profiles through an increase in 
      the serum level of OXA and alteration in the SAT phenotype from white to brown or 
      beige.
CI  - Copyright: (c) 2021 International Journal of Preventive Medicine.
FAU - Moslehi, Ebrahim
AU  - Moslehi E
AD  - Department of Exercise Physiology, University of Isfahan, Isfahan, Iran.
FAU - Minasian, Vazgen
AU  - Minasian V
AD  - Department of Exercise Physiology, University of Isfahan, Isfahan, Iran.
FAU - Sadeghi, Heibatollah
AU  - Sadeghi H
AD  - Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, 
      I.R. Iran.
LA  - eng
PT  - Journal Article
DEP - 20211019
PL  - Iran
TA  - Int J Prev Med
JT  - International journal of preventive medicine
JID - 101535380
PMC - PMC8631127
OTO - NOTNLM
OT  - Aerobic exercise
OT  - insulin resistance
OT  - obesity
OT  - orexin A
OT  - subcutaneous adipose tissue
COIS- There are no conflicts of interest.
EDAT- 2021/12/17 06:00
MHDA- 2021/12/17 06:01
PMCR- 2021/10/19
CRDT- 2021/12/16 06:32
PHST- 2019/03/23 00:00 [received]
PHST- 2019/12/04 00:00 [accepted]
PHST- 2021/12/16 06:32 [entrez]
PHST- 2021/12/17 06:00 [pubmed]
PHST- 2021/12/17 06:01 [medline]
PHST- 2021/10/19 00:00 [pmc-release]
AID - IJPVM-12-132 [pii]
AID - 10.4103/ijpvm.IJPVM_110_19 [doi]
PST - epublish
SO  - Int J Prev Med. 2021 Oct 19;12:132. doi: 10.4103/ijpvm.IJPVM_110_19. eCollection 
      2021.