PMID- 34912622
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231108
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 13
IP  - 11
DP  - 2021 Nov
TI  - Delayed Immune Reconstitution Inflammatory Syndrome in an Immunosuppressed 
      Patient With SARS-CoV-2.
PG  - e19481
LID - 10.7759/cureus.19481 [doi]
LID - e19481
AB  - Both immune reconstitution inflammatory syndrome (IRIS) and severe coronavirus 
      disease 2019 (COVID-19) are marked by hyperinflammation as a consequence of 
      dysfunction in myeloid cells and increased production of proinflammatory 
      cytokines. Although these features are common to both diseases, their 
      physiopathology remains unclear. Here we report the case of a 63-year-old woman 
      admitted for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 
      infection. In her clinical course, she developed acute respiratory distress 
      syndrome, probably triggered by the use of granulocyte colony-stimulating factor 
      (G-CSF). We hypothesize that G-CSF unmasked IRIS.
CI  - Copyright (c) 2021, Garcia-Carretero et al.
FAU - Garcia-Carretero, Rafael
AU  - Garcia-Carretero R
AD  - Department of Internal Medicine, Mostoles University Hospital, Mostoles, ESP.
FAU - Vazquez-Gomez, Oscar
AU  - Vazquez-Gomez O
AD  - Department of Internal Medicine, Mostoles University Hospital, Mostoles, ESP.
FAU - Ordonez-Garcia, Maria
AU  - Ordonez-Garcia M
AD  - Department of Hematology, Mostoles University Hospital, Mostoles, ESP.
LA  - eng
PT  - Case Reports
DEP - 20211111
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC8665849
OTO - NOTNLM
OT  - breast cancer
OT  - covid-19
OT  - granulocyte colony-stimulating factor
OT  - immune reconstitution inflammatory syndrome
OT  - immunosuppression
COIS- The authors have declared that no competing interests exist.
EDAT- 2021/12/17 06:00
MHDA- 2021/12/17 06:01
PMCR- 2021/11/11
CRDT- 2021/12/16 06:34
PHST- 2021/11/11 00:00 [accepted]
PHST- 2021/12/16 06:34 [entrez]
PHST- 2021/12/17 06:00 [pubmed]
PHST- 2021/12/17 06:01 [medline]
PHST- 2021/11/11 00:00 [pmc-release]
AID - 10.7759/cureus.19481 [doi]
PST - epublish
SO  - Cureus. 2021 Nov 11;13(11):e19481. doi: 10.7759/cureus.19481. eCollection 2021 
      Nov.