PMID- 34912858
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211217
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 8
DP  - 2021
TI  - Pediatric Acute Myocarditis With Short-Term Outcomes and Factors for 
      Extracorporeal Membrane Oxygenation: A Single-Center Retrospective Cohort Study 
      in Vietnam.
PG  - 741260
LID - 10.3389/fcvm.2021.741260 [doi]
LID - 741260
AB  - Objective: Data on the management and outcomes of acute myocarditis treated with 
      extracorporeal membrane oxygenation (ECMO) among low- and middle-income countries 
      are limited. This study aimed to determine the short-term outcomes and also 
      identify factors associated with ECMO use among children with acute myocarditis 
      at a tertiary children's hospital in Vietnam. Methods: A single-center, 
      retrospective observational study was conducted between January 2016 and February 
      2021. Pediatric patients with acute myocarditis, aged 1 month to 16 years, were 
      included. Results: In total, 54 patients (male, 46%; median age, 7 years) with 
      acute myocarditis were included; 37 of them received ECMO support. Thirty percent 
      (16/54) of the patients died, and 12 of them received ECMO. Laboratory variables 
      that differed between survivors and non-survivors included median left 
      ventricular ejection fraction (LVEF) at 48 h (42 vs. 25%; p = 0.001), platelet 
      count (304 g/L [interquartile range (IQR): 243-271] vs. 219 g/L [IQR: 167-297]; p 
      = 0.014), and protein (60 g/dl [IQR: 54-69] vs. 55 [IQR: 50-58]; p = 0.025). 
      Among patients who received ECMO, compared with the survivors, non-survivors had 
      a low LVEF at 48 h (odds ratio (OR), 0.8; 95% confidence interval (CI): 0.6-0.9; 
      p = 0.006) and high vasoactive-inotropic score (OR, 1.0; 95% CI: 1.0-1.0; p = 
      0.038) and lactate (OR, 2.8; 95% CI, 1.2-6.1; p = 0.013) at 24 h post-ECMO. 
      Conclusions: The case fatality rate among children with acute myocarditis was 30 
      and 32% among patients requiring ECMO support. Arrhythmia was an indicator for 
      ECMO in patients with cardiogenic shock.
CI  - Copyright (c) 2021 Tuan, Xoay, Phuc, Hung, Dung, Truong, Thuan and Dien.
FAU - Tuan, Ta Anh
AU  - Tuan TA
AD  - Pediatric Intensive Care Unit, Vietnam National Children's Hospital, Hanoi, 
      Vietnam.
AD  - Children's Department, University of Medicine and Pharmacy, Vietnam National 
      University, Hanoi, Vietnam.
AD  - Department of Pediatric, Hanoi Medical University, Hanoi, Vietnam.
FAU - Xoay, Tran Dang
AU  - Xoay TD
AD  - Pediatric Intensive Care Unit, Vietnam National Children's Hospital, Hanoi, 
      Vietnam.
FAU - Phuc, Phan Huu
AU  - Phuc PH
AD  - Pediatric Intensive Care Unit, Vietnam National Children's Hospital, Hanoi, 
      Vietnam.
FAU - Hung, Dau Viet
AU  - Hung DV
AD  - Pediatric Intensive Care Unit, Vietnam National Children's Hospital, Hanoi, 
      Vietnam.
AD  - Children's Department, University of Medicine and Pharmacy, Vietnam National 
      University, Hanoi, Vietnam.
FAU - Dung, Nguyen Trong
AU  - Dung NT
AD  - Pediatric Intensive Care Unit, Vietnam National Children's Hospital, Hanoi, 
      Vietnam.
FAU - Truong, Nguyen Ly Thinh
AU  - Truong NLT
AD  - Department of Cardiovascular Surgery, Children Heart Center, Vietnam National 
      Children's Hospital, Hanoi, Vietnam.
FAU - Thuan, Nguyen Van
AU  - Thuan NV
AD  - Surgical Intensive Care Unit, Vietnam National Children's Hospital, Hanoi, 
      Vietnam.
FAU - Dien, Tran Minh
AU  - Dien TM
AD  - Children's Department, University of Medicine and Pharmacy, Vietnam National 
      University, Hanoi, Vietnam.
AD  - Surgical Intensive Care Unit, Vietnam National Children's Hospital, Hanoi, 
      Vietnam.
LA  - eng
PT  - Journal Article
DEP - 20211129
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC8666974
OTO - NOTNLM
OT  - acute myocarditis
OT  - cardiac arrhythmia
OT  - extracorporeal membrane oxygenation
OT  - mortality
OT  - pediatrics
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/12/17 06:00
MHDA- 2021/12/17 06:01
PMCR- 2021/01/01
CRDT- 2021/12/16 06:36
PHST- 2021/07/14 00:00 [received]
PHST- 2021/11/02 00:00 [accepted]
PHST- 2021/12/16 06:36 [entrez]
PHST- 2021/12/17 06:00 [pubmed]
PHST- 2021/12/17 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2021.741260 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2021 Nov 29;8:741260. doi: 10.3389/fcvm.2021.741260. 
      eCollection 2021.