PMID- 3491337
OWN - NLM
STAT- MEDLINE
DCOM- 19870102
LR  - 20190726
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 25
IP  - 10
DP  - 1986 Oct
TI  - Reversal of tolerance to morphine but no potentiation of morphine-induced 
      analgesia by antiserum against cholecystokinin octapeptide.
PG  - 1155-60
AB  - Tolerance to morphine analgesia was induced in rats by chronic treatment with 
      morphine (5-30 mg/kg, t.i.d. for 6 days). Intracerebroventricular (i.c.v.) 
      injection of antiserum against cholecystokinin octapeptide (CCK-8) reversed 
      tolerance to morphine by 50% (P less than 0.001). Intrathecal (ith) injection of 
      the CCK-8 antiserum produced a similar, although less marked, reversal of 
      tolerance to morphine. Rats made tolerant to analgesia induced by morphine 
      developed a cross tolerance to electroacupuncture-induced analgesia. This cross 
      tolerance was also reversed by the CCK-8 antiserum by more than 50% (P less than 
      0.001). Intracerebroventricular or intrathecal injection of the CCK-8 antiserum 
      per se produced no significant changes in the basal level of the latency of the 
      tail flick response, nor did it affect the analgesia induced by morphine in naive 
      rats. The results suggest that prolonged activation of opioid receptors may 
      trigger the CCK-8 system in the central nervous system to exert a negative 
      feedback control, which may constitute one of the mechanisms for the development 
      of tolerance to opioids.
FAU - Ding, X Z
AU  - Ding XZ
FAU - Fan, S G
AU  - Fan SG
FAU - Zhou, J P
AU  - Zhou JP
FAU - Han, J S
AU  - Han JS
LA  - eng
PT  - Journal Article
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 76I7G6D29C (Morphine)
RN  - M03GIQ7Z6P (Sincalide)
SB  - IM
MH  - *Analgesia
MH  - Animals
MH  - Drug Tolerance
MH  - Female
MH  - *Immunization, Passive
MH  - Injections, Intraventricular
MH  - Injections, Spinal
MH  - Male
MH  - Morphine/*pharmacology
MH  - Pain Measurement
MH  - Rats
MH  - Sincalide/immunology/*physiology
MH  - Transcutaneous Electric Nerve Stimulation
EDAT- 1986/10/01 00:00
MHDA- 1986/10/01 00:01
CRDT- 1986/10/01 00:00
PHST- 1986/10/01 00:00 [pubmed]
PHST- 1986/10/01 00:01 [medline]
PHST- 1986/10/01 00:00 [entrez]
AID - 10.1016/0028-3908(86)90164-4 [doi]
PST - ppublish
SO  - Neuropharmacology. 1986 Oct;25(10):1155-60. doi: 10.1016/0028-3908(86)90164-4.