PMID- 34915278
OWN - NLM
STAT- MEDLINE
DCOM- 20220401
LR  - 20220401
IS  - 1872-7603 (Electronic)
IS  - 0165-0378 (Linking)
VI  - 149
DP  - 2022 Feb
TI  - The role of dendritic cells in endometriosis: A systematic review.
PG  - 103462
LID - S0165-0378(21)00192-3 [pii]
LID - 10.1016/j.jri.2021.103462 [doi]
AB  - Endometriosis (EDT), a common estrogen-dependent inflammatory disorder, is 
      characterized by endometrial-like tissue outside the uterus. While its 
      pathogenesis is poorly understood, it is supposed that the immune system plays a 
      role in its pathophysiology, and increased number of immune cells and changes in 
      both cell-mediated and humoral immunity have been described. Dendritic cells 
      (DCs) are antigen-presenting cells (APC) of the immune system that recognize, 
      capture, and process complex antigens and present them to T cells, conferring 
      them a unique ability as mediators between the innate and adaptive immune 
      systems. This systematic review aims to enlighten possible disturbances 
      (systemically and locally) of DCs in the development and progression of 
      endometriosis. A search using the strategy: ("dendritic cells" AND "immunology" 
      AND "endometriosis") in databases resulted in 490 citations; after applying 
      inclusion and exclusion criteria, a total of 13 studies were assessed. The 
      evaluated studies demonstrated that DCs are susceptible to pro-endometriotic 
      changes which could inhibit immature DCs (imDCs) from their maturation and induce 
      imDCs into a macrophage phenotype. In addition, the growth and vascularization of 
      endometriosis requires the presence of endogenous DC, which infiltrate 
      endometriotic lesions and enhance endothelial cell migration by secreting 
      proangiogenic factors. Whereas DC maturation suppresses this response, imDC 
      actively promote angiogenesis and growth, leading to a switch in their 
      immunologic role from presenting antigens to support angiogenesis and EDT 
      progression.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Laginha, Paulo Arantes
AU  - Laginha PA
AD  - Disciplina de Ginecologia, Departamento de Obstetricia e Ginecologia, Faculdade 
      de Medicina FMUSP, Universidade de Sao Paulo, Av. Dr. Eneas Carvalho de Aguiar, 
      255 - Cerqueira Cesar, Sao Paulo, SP, 05403-000, Brazil. Electronic address: 
      laginhap@hotmail.com.
FAU - Arcoverde, Fernanda Vieira Lins
AU  - Arcoverde FVL
AD  - Servico de Ginecologia, Hospital Universitario Materno Infantil (UFMA), R. Silva 
      Jardim, s/n - Centro, Sao Luis, MA, 65021-000, Brazil. Electronic address: 
      fernandaarcoverde@hotmail.com.
FAU - Riccio, Luiza Gama Coelho
AU  - Riccio LGC
AD  - Disciplina de Ginecologia, Departamento de Obstetricia e Ginecologia, Faculdade 
      de Medicina FMUSP, Universidade de Sao Paulo, Av. Dr. Eneas Carvalho de Aguiar, 
      255 - Cerqueira Cesar, Sao Paulo, SP, 05403-000, Brazil. Electronic address: 
      luiza.riccio@gmail.com.
FAU - Andres, Marina Paula
AU  - Andres MP
AD  - Disciplina de Ginecologia, Departamento de Obstetricia e Ginecologia, Faculdade 
      de Medicina FMUSP, Universidade de Sao Paulo, Av. Dr. Eneas Carvalho de Aguiar, 
      255 - Cerqueira Cesar, Sao Paulo, SP, 05403-000, Brazil; Gynecologic Division, BP 
      - A Beneficencia Portuguesa de Sao Paulo, R. Maestro Cardim, 769 - Bela Vista, 
      Sao Paulo, SP, 01323-001, Brazil. Electronic address: marina.dpandres@gmail.com.
FAU - Abrao, Mauricio Simoes
AU  - Abrao MS
AD  - Disciplina de Ginecologia, Departamento de Obstetricia e Ginecologia, Faculdade 
      de Medicina FMUSP, Universidade de Sao Paulo, Av. Dr. Eneas Carvalho de Aguiar, 
      255 - Cerqueira Cesar, Sao Paulo, SP, 05403-000, Brazil; Gynecologic Division, BP 
      - A Beneficencia Portuguesa de Sao Paulo, R. Maestro Cardim, 769 - Bela Vista, 
      Sao Paulo, SP, 01323-001, Brazil. Electronic address: msabrao@mac.com.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20211209
PL  - Ireland
TA  - J Reprod Immunol
JT  - Journal of reproductive immunology
JID - 8001906
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Cell Differentiation
MH  - Dendritic Cells/*immunology
MH  - Endometriosis/*immunology
MH  - Endothelial Cells/*physiology
MH  - Female
MH  - Humans
MH  - Neovascularization, Pathologic
OTO - NOTNLM
OT  - Dendritic cells
OT  - Endometriosis
OT  - Immune system
OT  - Immunology
EDAT- 2021/12/17 06:00
MHDA- 2022/04/02 06:00
CRDT- 2021/12/16 20:25
PHST- 2021/08/31 00:00 [received]
PHST- 2021/12/02 00:00 [revised]
PHST- 2021/12/07 00:00 [accepted]
PHST- 2021/12/17 06:00 [pubmed]
PHST- 2022/04/02 06:00 [medline]
PHST- 2021/12/16 20:25 [entrez]
AID - S0165-0378(21)00192-3 [pii]
AID - 10.1016/j.jri.2021.103462 [doi]
PST - ppublish
SO  - J Reprod Immunol. 2022 Feb;149:103462. doi: 10.1016/j.jri.2021.103462. Epub 2021 
      Dec 9.