PMID- 34915678
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2149-2042 (Print)
IS  - 2149-4606 (Electronic)
IS  - 2149-4606 (Linking)
VI  - 36
IP  - 3
DP  - 2021
TI  - Does Early Diabetic Kidney Damage Alter Renal Elasticity? An Ultrasound-Based, 
      Two-Dimensional Shear Wave Elastography Study.
PG  - 209-216
LID - 10.5222/MMJ.2021.65021 [doi]
AB  - OBJECTIVE: Kidney damage caused by type 2 diabetes mellitus (T2DM) can reduce 
      renal elasticity. Limited number of data exist indicating whether early kidney 
      damage causes stiffening of renal tissue. This comparative study aims to assess 
      kidney elasticity in T2DM patients with or without moderate albuminuria, using 
      ultrasound-based two-dimensional shear wave velocity (2D-SWV) measurements. 
      METHODS: Fifty-seven cases (40 T2D patients with stage 1 or 2 chronic kidney 
      disease and 17 age- and sex-matched healthy controls) were included in this 
      single-center prospective study. The T2DM patients were divided into those with 
      moderate albuminuria (n=22) and those without albuminuria (n=18). Bilateral renal 
      parenchymal 2D-SWV values were measured (separately) in the upper, middle, and 
      lower kidney regions. Group data were compared using the t-test or Mann-Whitney-U 
      test (whichever appropriate). Inter-observer agreement was assessed by deriving 
      the intra-class correlation coefficient. RESULTS: There was no difference between 
      the T2DM and control groups in terms of the median age [55.5 (50-62) vs. 55 
      (48.5-59.5) years, p=0.48] and sex ratio [18 (45%) males vs. 10 (58.8%) females, 
      p=0.34]. The average regional 2D-SWV values were all similar between the groups 
      (all p>0.05). The average 2D-SWV values were similar between the subgroups with 
      and without albuminuria. The inter-observer agreement was good (intra-class 
      correlation coefficient=0.66, 95% CI 0.19-0.88, p=0.006). CONCLUSION: Kidney 
      elasticity does not seem to be compromised in patients with diabetes and 
      preserved estimated glomerular filtration rate with or without moderate 
      albuminuria.
CI  - (c) Copyright Istanbul Medeniyet University Faculty of Medicine.
FAU - Gunduz, Nesrin
AU  - Gunduz N
AUID- ORCID: 0000-0001-8754-5676
AD  - Istanbul Medeniyet University, School of Medicine, Department of Radiology, 
      Istanbul, Turkey.
FAU - Buz, Aysenur
AU  - Buz A
AUID- ORCID: 0000-0003-1324-2810
AD  - Istanbul Medeniyet University, School of Medicine, Department of Radiology, 
      Istanbul, Turkey.
FAU - Kabaalioglu, Adnan
AU  - Kabaalioglu A
AUID- ORCID: 0000-0001-6247-1738
AD  - Istanbul Medeniyet University, School of Medicine, Department of Radiology, 
      Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20210930
PL  - Turkey
TA  - Medeni Med J
JT  - Medeniyet medical journal
JID - 101676811
PMC - PMC8565583
OTO - NOTNLM
OT  - Shear wave elastography
OT  - albuminuria
OT  - diabetes mellitus
COIS- Conflict of interest: The authors declare that they have no conflict of interest.
EDAT- 2021/12/18 06:00
MHDA- 2021/12/18 06:01
PMCR- 2021/09/30
CRDT- 2021/12/17 02:46
PHST- 2021/06/26 00:00 [received]
PHST- 2021/08/30 00:00 [accepted]
PHST- 2021/12/17 02:46 [entrez]
PHST- 2021/12/18 06:00 [pubmed]
PHST- 2021/12/18 06:01 [medline]
PHST- 2021/09/30 00:00 [pmc-release]
AID - 10.5222/MMJ.2021.65021 [doi]
PST - ppublish
SO  - Medeni Med J. 2021;36(3):209-216. doi: 10.5222/MMJ.2021.65021. Epub 2021 Sep 30.