PMID- 34916664
OWN - NLM
STAT- MEDLINE
DCOM- 20220225
LR  - 20230211
IS  - 1348-4214 (Electronic)
IS  - 0916-9636 (Linking)
VI  - 45
IP  - 3
DP  - 2022 Mar
TI  - Distribution and maturation state of peripheral blood dendritic cells in children 
      with primary hypertension.
PG  - 401-413
LID - 10.1038/s41440-021-00809-9 [doi]
AB  - Dendritic cells (DCs) play an important role in T cell alterations in primary 
      hypertension (PH). We determined the numbers and maturation markers of peripheral 
      blood total DCs (tDCs), myeloid cells (mDCs), and plasmacytoid cells (pDCs) and 
      their association with hypertension-mediated organ damage (HMOD) markers and 
      selected immune parameters in 30 adolescents with white coat hypertension (WCH), 
      25 adolescents with PH and a group of 35 age- and sex-matched children with 
      normotension. Using multicolor flow cytometry, expression of maturation markers 
      (CD86 and CD83) in tDCs (Lin1(-)/HLA-DR(+)), myeloid DCs 
      (Lin1(-)/HLA-DR(+)/CD11c(+)) (mDCs), and plasmacytoid DCs 
      (Lin1(-)/HLA-DR(+)/CD123(+)) (pDCs) and the distribution of peripheral 
      Th17-bearing and T-reg cells were defined. In subjects with hypertension, carotid 
      intima-media thickness (cIMT), left ventricular mass index (LVMI), and pulse wave 
      velocity (PWV) were assessed. Compared with WCH and subjects with normotension, 
      subjects with hypertension had reduced tDC and pDC numbers, an increased 
      percentage of mDC subsets, an elevated mDC/pDC ratio, an increased population of 
      mature mDC and pDC subsets bearing CD83 of high density, a decreased subset of 
      CD86-bearing pDCs, and increased expression of DC activation markers (HLA-DR, 
      CD86), as well as CD11c (mDCs) and CD123 (pDCs). PWV, LVMI, and cIMT values 
      correlated negatively with tDCs and pDCs and positively with mDC numbers. 
      Expression of DC maturation/activation markers (CD83, CD86, HLA-DR, CD11c, and 
      CD123) correlated positively with PWV. Certain DC characteristics of WCH subjects 
      resembled those of PH subjects (decreased tDC frequency and upregulation of 
      activation marker expression). These changes correlated with HMOD. WCH subjects 
      presented a DC phenotype that was intermediate between the normotensive and 
      hypertensive phenotypes.
CI  - (c) 2021. The Author(s), under exclusive licence to The Japanese Society of 
      Hypertension.
FAU - Kubiszewska, Izabela
AU  - Kubiszewska I
AD  - Department of Immunology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, 
      Nicolaus Copernicus University in Torun, Torun, Poland.
FAU - Gackowska, Lidia
AU  - Gackowska L
AD  - Department of Immunology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, 
      Nicolaus Copernicus University in Torun, Torun, Poland.
FAU - Obrycki, Lukasz
AU  - Obrycki L
AD  - Department of Nephrology, Kidney Transplantation and Arterial Hypertension, The 
      Children's Memorial Health Institute, Warsaw, Poland.
FAU - Wierzbicka, Aldona
AU  - Wierzbicka A
AD  - Department of Biochemistry and Experimental Medicine, The Children's Memorial 
      Health Institute, Warsaw, Poland.
FAU - Helmin-Basa, Anna
AU  - Helmin-Basa A
AD  - Department of Immunology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, 
      Nicolaus Copernicus University in Torun, Torun, Poland.
FAU - Kulaga, Zbigniew
AU  - Kulaga Z
AD  - Department of Public Health, The Children's Memorial Health Institute, Warsaw, 
      Poland.
FAU - Wiese-Szadkowska, Malgorzta
AU  - Wiese-Szadkowska M
AD  - Department of Immunology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, 
      Nicolaus Copernicus University in Torun, Torun, Poland.
FAU - Michalkiewicz, Jacek
AU  - Michalkiewicz J
AD  - Department of Immunology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, 
      Nicolaus Copernicus University in Torun, Torun, Poland.
AD  - Department of Microbiology and Clinical Immunology, The Children's Memorial 
      Health Institute, Warsaw, Poland.
FAU - Litwin, Mieczyslaw
AU  - Litwin M
AD  - Department of Nephrology, Kidney Transplantation and Arterial Hypertension, The 
      Children's Memorial Health Institute, Warsaw, Poland. m.litwin@ipczd.pl.
LA  - eng
PT  - Journal Article
DEP - 20211216
PL  - England
TA  - Hypertens Res
JT  - Hypertension research : official journal of the Japanese Society of Hypertension
JID - 9307690
SB  - IM
CIN - Hypertens Res. 2022 Mar;45(3):527-529. PMID: 34961789
MH  - Adolescent
MH  - Carotid Intima-Media Thickness
MH  - Dendritic Cells/metabolism
MH  - Flow Cytometry
MH  - Humans
MH  - *Hypertension/metabolism
MH  - *Pulse Wave Analysis
OTO - NOTNLM
OT  - arterial stiffness
OT  - children
OT  - dendritic cells
OT  - lymphocyte maturation
OT  - primary hypertension
EDAT- 2021/12/18 06:00
MHDA- 2022/02/26 06:00
CRDT- 2021/12/17 06:47
PHST- 2021/07/26 00:00 [received]
PHST- 2021/10/28 00:00 [accepted]
PHST- 2021/10/18 00:00 [revised]
PHST- 2021/12/18 06:00 [pubmed]
PHST- 2022/02/26 06:00 [medline]
PHST- 2021/12/17 06:47 [entrez]
AID - 10.1038/s41440-021-00809-9 [pii]
AID - 10.1038/s41440-021-00809-9 [doi]
PST - ppublish
SO  - Hypertens Res. 2022 Mar;45(3):401-413. doi: 10.1038/s41440-021-00809-9. Epub 2021 
      Dec 16.