PMID- 34916926
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211218
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 13
DP  - 2021
TI  - Deficits in N-Methyl-D-Aspartate Receptor Function and Synaptic Plasticity in 
      Hippocampal CA1 in APP/PS1 Mouse Model of Alzheimer's Disease.
PG  - 772980
LID - 10.3389/fnagi.2021.772980 [doi]
LID - 772980
AB  - The N-methyl-D-aspartate receptor is a critical molecule for synaptic plasticity 
      and cognitive function. Impaired synaptic plasticity is thought to contribute to 
      the cognitive impairment associated with Alzheimer's disease (AD). However, the 
      neuropathophysiological alterations of N-methyl-D-aspartate receptor (NMDAR) 
      function and synaptic plasticity in hippocampal CA1 in transgenic rodent models 
      of AD are still unclear. In the present study, APP/PS1 mice were utilized as a 
      transgenic model of AD, which exhibited progressive cognitive impairment 
      including defective working memory, recognition memory, and spatial memory 
      starting at 6 months of age and more severe by 8 months of age. We found an 
      impaired long-term potentiation (LTP) and reduced NMDAR-mediated spontaneous 
      excitatory postsynaptic currents (sEPSCs) in the hippocampal CA1 of APP/PS1 mice 
      with 8 months of age. Golgi staining revealed that dendrites of pyramidal neurons 
      had shorter length, fewer intersections, and lower spine density in APP/PS1 mice 
      compared to control mice. Further, the reduced expression levels of NMDAR 
      subunits, PSD95 and SNAP25 were observed in the hippocampus of APP/PS1 mice. 
      These results suggest that NMDAR dysfunction, impaired synaptic plasticity, and 
      disrupted neuronal morphology constitute an important part of the 
      neuropathophysiological alterations associated with cognitive impairment in 
      APP/PS1 mice.
CI  - Copyright (c) 2021 Xu, Zhou, Hu, Jiang, Dong, Shen, Lou, Yang, Ji, Ruan and Zhang.
FAU - Xu, Le
AU  - Xu L
AD  - Zhejiang Key Laboratory of Pathophysiology, Department of Pharmacology, School of 
      Medicine, Ningbo University, Ningbo, China.
AD  - Department of Psychosomatic Medicine, Ningbo First Hospital, Ningbo Hospital of 
      Zhejiang University, Ningbo, China.
FAU - Zhou, Yiying
AU  - Zhou Y
AD  - Zhejiang Key Laboratory of Pathophysiology, Department of Pharmacology, School of 
      Medicine, Ningbo University, Ningbo, China.
AD  - Key Laboratory of Addiction Research of Zhejiang Province, Ningbo Kangning 
      Hospital, Ningbo, China.
FAU - Hu, Linbo
AU  - Hu L
AD  - Zhejiang Key Laboratory of Pathophysiology, Department of Pharmacology, School of 
      Medicine, Ningbo University, Ningbo, China.
FAU - Jiang, Hongde
AU  - Jiang H
AD  - Zhejiang Key Laboratory of Pathophysiology, Department of Pharmacology, School of 
      Medicine, Ningbo University, Ningbo, China.
FAU - Dong, Yibei
AU  - Dong Y
AD  - Zhejiang Key Laboratory of Pathophysiology, Department of Pharmacology, School of 
      Medicine, Ningbo University, Ningbo, China.
FAU - Shen, Haowei
AU  - Shen H
AD  - Zhejiang Key Laboratory of Pathophysiology, Department of Pharmacology, School of 
      Medicine, Ningbo University, Ningbo, China.
AD  - Key Laboratory of Addiction Research of Zhejiang Province, Ningbo Kangning 
      Hospital, Ningbo, China.
FAU - Lou, Zhongze
AU  - Lou Z
AD  - Department of Psychosomatic Medicine, Ningbo First Hospital, Ningbo Hospital of 
      Zhejiang University, Ningbo, China.
AD  - Central Laboratory of the Medical Research Center, Ningbo First Hospital, Ningbo 
      Hospital of Zhejiang University, Ningbo, China.
FAU - Yang, Siyu
AU  - Yang S
AD  - Zhejiang Key Laboratory of Pathophysiology, Department of Pharmacology, School of 
      Medicine, Ningbo University, Ningbo, China.
FAU - Ji, Yunxin
AU  - Ji Y
AD  - Department of Psychosomatic Medicine, Ningbo First Hospital, Ningbo Hospital of 
      Zhejiang University, Ningbo, China.
FAU - Ruan, Liemin
AU  - Ruan L
AD  - Department of Psychosomatic Medicine, Ningbo First Hospital, Ningbo Hospital of 
      Zhejiang University, Ningbo, China.
FAU - Zhang, Xiaoqin
AU  - Zhang X
AD  - Zhejiang Key Laboratory of Pathophysiology, Department of Pharmacology, School of 
      Medicine, Ningbo University, Ningbo, China.
AD  - Key Laboratory of Addiction Research of Zhejiang Province, Ningbo Kangning 
      Hospital, Ningbo, China.
LA  - eng
PT  - Journal Article
DEP - 20211130
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC8669806
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - NMDAR
OT  - cognitive behavior
OT  - dendritic morphology
OT  - synaptic plasticity
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/12/18 06:00
MHDA- 2021/12/18 06:01
PMCR- 2021/01/01
CRDT- 2021/12/17 06:52
PHST- 2021/09/09 00:00 [received]
PHST- 2021/10/29 00:00 [accepted]
PHST- 2021/12/17 06:52 [entrez]
PHST- 2021/12/18 06:00 [pubmed]
PHST- 2021/12/18 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2021.772980 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2021 Nov 30;13:772980. doi: 10.3389/fnagi.2021.772980. 
      eCollection 2021.