PMID- 34917295
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220429
IS  - 2008-126X (Print)
IS  - 2228-7442 (Electronic)
IS  - 2008-126X (Linking)
VI  - 12
IP  - 3
DP  - 2021 May-Jun
TI  - Comparing the Effects of Rosemary Extract and Treadmill Exercise on the 
      Hippocampal Function and Antioxidant Capacity in Old Rats.
PG  - 361-372
LID - 10.32598/bcn.12.3.2139.1 [doi]
AB  - INTRODUCTION: A sequence of time-dependent changes can affect the brain's 
      functional capacity.This study aimed at investigating the effects of Forced 
      Aerobic Exercise (FAE) versus the Rosemary Extract (RE) on the learning abilities 
      and oxidative stress modulation in rats. METHODS: Young and old rats received 
      daily FAE and RE for 3 months. Using the Passive Avoidance (PA) test, we 
      evaluated the learning and memory of the rats by Step-Through Latency (STL) 
      score. We measured the Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx), 
      Catalase (CATA), Malondialdehyde (MDA) enzymes levels, and Total Antioxidant 
      Capacity (TAC) in the hippocampus. RESULTS: FAE could significantly increase the 
      STL score (P<0.001) among old rats similar to the rosemary extract consumption. 
      The SOD, GPx, and CATA enzyme activities and the level of TAC significantly 
      increased by the treatments (exercise: P<0.001 for SOD and TAC and P<0.05 for 
      CATA, exercise/rosemary: P<0.001 for all enzymes, and rosemary: P<0.01 for SOD 
      and TAC). Furthermore, the MDA level significantly decreased by the treatments 
      (exercise and exercise/rosemary: P<0.001, rosemary: P<0.01). The partial Pearson 
      test revealed the significant positive correlations between the score of STL (day 
      2) with the SOD (P<0.01) and TAC (P<0.05) levels and negative correlations 
      between the MDA level and STL score in both days (P<0.05 for the first day and 
      P<0.001 for the second day). CONCLUSION: Similar to the rosemary extract, FAE 
      could increase the working memory and antioxidants activity in old rats in 3 
      months.
CI  - Copyright(c) 2021 Iranian Neuroscience Society.
FAU - Rasoolijazi, Homa
AU  - Rasoolijazi H
AUID- ORCID: 0000-0003-0051-9171
AD  - Cellular & Molecular Research Center, Iran University of Medical Sciences, 
      Tehran, Iran.
AD  - Department of Anatomy, School of Medicine, Iran University of Medical Sciences, 
      Tehran, Iran.
AD  - Department of Neuroscience, School of Advanced Technologies in Medicine, Iran 
      University of Medical Sciences, Tehran, Iran.
FAU - Norouzi Ofogh, Sattar
AU  - Norouzi Ofogh S
AUID- ORCID: 0000-0001-7715-1657
AD  - Department of Neuroscience, School of Advanced Technologies in Medicine, Iran 
      University of Medical Sciences, Tehran, Iran.
FAU - Ababzadeh, Shima
AU  - Ababzadeh S
AUID- ORCID: 0000-0002-3481-9714
AD  - Cellular & Molecular Research Center, Iran University of Medical Sciences, 
      Tehran, Iran.
AD  - Department of Anatomy, School of Medicine, Iran University of Medical Sciences, 
      Tehran, Iran.
FAU - Mehdizadeh, Mehdi
AU  - Mehdizadeh M
AUID- ORCID: 0000-0002-9268-7318
AD  - Cellular & Molecular Research Center, Iran University of Medical Sciences, 
      Tehran, Iran.
AD  - Department of Anatomy, School of Medicine, Iran University of Medical Sciences, 
      Tehran, Iran.
FAU - Shabkhiz, Fatemeh
AU  - Shabkhiz F
AUID- ORCID: 0000-0003-1183-9517
AD  - Department of Neuroscience, School of Advanced Technologies in Medicine, Iran 
      University of Medical Sciences, Tehran, Iran.
AD  - Department of Exercise Physiology, Faculty of Physical Education and Sport 
      Sciences, University of Tehran, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20210501
PL  - Iran
TA  - Basic Clin Neurosci
JT  - Basic and clinical neuroscience
JID - 101575211
PMC - PMC8666924
OTO - NOTNLM
OT  - Aerobic exercise
OT  - Aging
OT  - Antioxidant
OT  - Cognition
OT  - Enzymes
COIS- Conflict of interest The authors declared no conflict of interest.
EDAT- 2021/12/18 06:00
MHDA- 2021/12/18 06:01
PMCR- 2021/05/01
CRDT- 2021/12/17 06:55
PHST- 2019/10/26 00:00 [received]
PHST- 2019/11/15 00:00 [revised]
PHST- 2020/04/07 00:00 [accepted]
PHST- 2021/12/17 06:55 [entrez]
PHST- 2021/12/18 06:00 [pubmed]
PHST- 2021/12/18 06:01 [medline]
PHST- 2021/05/01 00:00 [pmc-release]
AID - bcn-12-361 [pii]
AID - 10.32598/bcn.12.3.2139.1 [doi]
PST - ppublish
SO  - Basic Clin Neurosci. 2021 May-Jun;12(3):361-372. doi: 10.32598/bcn.12.3.2139.1. 
      Epub 2021 May 1.