PMID- 34917616
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211218
IS  - 2296-634X (Print)
IS  - 2296-634X (Electronic)
IS  - 2296-634X (Linking)
VI  - 9
DP  - 2021
TI  - Steroid-Induced Osteonecrosis of the Femoral Head: Novel Insight Into the Roles 
      of Bone Endothelial Cells in Pathogenesis and Treatment.
PG  - 777697
LID - 10.3389/fcell.2021.777697 [doi]
LID - 777697
AB  - Steroid-induced osteonecrosis of the femoral head (SONFH) is a disease 
      characterized by the collapse of the femoral head. SONFH occurs due to the 
      overuse of glucocorticoids (GCs) in patients with immune-related diseases. Among 
      various pathogenesis proposed, the mechanism related to impaired blood vessels is 
      gradually becoming the most convincing hypothesis. Bone endothelial cells 
      including bone microvascular endothelial cells (BMECs) and endothelial progenitor 
      cells (EPCs) play a crucial role in the maintenance of vascular homeostasis. 
      Therefore, bone endothelial cells are key regulators in the occurrence and 
      progression of SONFH. Impaired angiogenesis, abnormal apoptosis, thrombosis and 
      fat embolism caused by the dysfunctions of bone endothelial cells are considered 
      to be the pathogenesis of SONFH. In addition, even with high disability rates, 
      SONFH lacks effective therapeutic approach. Icariin (ICA, a flavonoid extracted 
      from Epimedii Herba), pravastatin, and VO-OHpic (a potent inhibitor of PTEN) are 
      candidate reagents to prevent and treat SONFH through improving above 
      pathological processes. However, these reagents are still in the preclinical 
      stage and will not be widely used temporarily. In this case, bone tissue 
      engineering represented by co-transplantation of bone endothelial cells and bone 
      marrow mesenchymal stem cells (BMSCs) may be another feasible therapeutic 
      strategy.
CI  - Copyright (c) 2021 Huang, Wen, Niu, Lin and Wang.
FAU - Huang, Cheng
AU  - Huang C
AD  - Department of Orthopedics, China-Japan Friendship Hospital, Beijing, China.
FAU - Wen, Zeqin
AU  - Wen Z
AD  - Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, 
      China.
FAU - Niu, Junjie
AU  - Niu J
AD  - Department of Orthopedics, The First Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Lin, Subin
AU  - Lin S
AD  - Department of Orthopedics, The Second Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Wang, Weiguo
AU  - Wang W
AD  - Department of Orthopedics, China-Japan Friendship Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20211130
PL  - Switzerland
TA  - Front Cell Dev Biol
JT  - Frontiers in cell and developmental biology
JID - 101630250
PMC - PMC8670327
OTO - NOTNLM
OT  - angiogenesis
OT  - bone endothelial cells
OT  - bone microvascular endothelial cells
OT  - bone progenitor cells
OT  - pathogenesis
OT  - steroid-induced osteonecrosis of the femoral head
OT  - treatment
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/12/18 06:00
MHDA- 2021/12/18 06:01
PMCR- 2021/01/01
CRDT- 2021/12/17 06:59
PHST- 2021/09/15 00:00 [received]
PHST- 2021/11/16 00:00 [accepted]
PHST- 2021/12/17 06:59 [entrez]
PHST- 2021/12/18 06:00 [pubmed]
PHST- 2021/12/18 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 777697 [pii]
AID - 10.3389/fcell.2021.777697 [doi]
PST - epublish
SO  - Front Cell Dev Biol. 2021 Nov 30;9:777697. doi: 10.3389/fcell.2021.777697. 
      eCollection 2021.