PMID- 34917649
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211218
IS  - 2296-889X (Print)
IS  - 2296-889X (Electronic)
IS  - 2296-889X (Linking)
VI  - 8
DP  - 2021
TI  - A Novel Diagnostic Biomarker, PZP, for Detecting Colorectal Cancer in Type 2 
      Diabetes Mellitus Patients Identified by Serum-Based Mass Spectrometry.
PG  - 736272
LID - 10.3389/fmolb.2021.736272 [doi]
LID - 736272
AB  - Background: Growing evidence has confirmed that populations with type 2 diabetes 
      mellitus (T2DM) have an increasing risk of developing colorectal cancer (CRC). 
      Thus, convenient and effective screening strategies for CRC should be developed 
      for the T2DM population to increase the detection rate of CRC. Methods: Twenty 
      serum samples extracted from five healthy participants, five T2DM patients, five 
      CRC patients and five T2DM patients with CRC (T2DM + CRC) were submitted to 
      data-independent acquisition mass spectrometry (DIA-MS) analysis to discover 
      unique differentially altered proteins (DAPs) for CRC in patients with T2DM. 
      Then, the diagnostic value of pregnancy zone protein (PZP) was validated by ELISA 
      analysis in the validated cohort. Results: Based on DIA-MS analysis, we found 
      eight unique proteins specific to T2DM patients with CRC. Among these proteins, 
      four proteins showed different expression between the T2DM + CRC and T2DM groups, 
      and PZP exhibited the largest difference. Next, the diagnostic value of serum PZP 
      was validated by ELISA analysis with an AUC of 0.713. Moreover, the combination 
      of PZP, CA199 and CEA exhibited encouraging diagnostic value, and the AUC reached 
      0.916. Conclusion: Overall, our current research implied that PZP could be 
      regarded as a newfound serum biomarker for CRC medical diagnosis in T2DM 
      patients.
CI  - Copyright (c) 2021 Yang, Fang, Wu, Tian, Gao, Yu, Chen, Weng, Zhu and Yang.
FAU - Yang, Jiayue
AU  - Yang J
AD  - Department of Endocrinology, The Affiliated Wuxi People's Hospital of Nanjing 
      Medical University, Wuxi, China.
FAU - Fang, Weigang
AU  - Fang W
AD  - Department of Gastroenterology, The Affiliated Wuxi People's Hospital of Nanjing 
      Medical University, Wuxi, China.
FAU - Wu, Wenjun
AU  - Wu W
AD  - Department of Endocrinology, The Affiliated Wuxi People's Hospital of Nanjing 
      Medical University, Wuxi, China.
FAU - Tian, Zhen
AU  - Tian Z
AD  - Department of Clinical Laboratory, The Affiliated Wuxi People's Hospital of 
      Nanjing Medical University, Wuxi, China.
FAU - Gao, Rong
AU  - Gao R
AD  - Department of Clinical Laboratory, The Affiliated Wuxi People's Hospital of 
      Nanjing Medical University, Wuxi, China.
FAU - Yu, Lu
AU  - Yu L
AD  - Department of Endocrinology, The Affiliated Wuxi People's Hospital of Nanjing 
      Medical University, Wuxi, China.
FAU - Chen, Dayang
AU  - Chen D
AD  - Department of Gastroenterology, The Affiliated Wuxi People's Hospital of Nanjing 
      Medical University, Wuxi, China.
FAU - Weng, Xiaohua
AU  - Weng X
AD  - Department of Endocrinology, The Affiliated Wuxi People's Hospital of Nanjing 
      Medical University, Wuxi, China.
FAU - Zhu, Shengwei
AU  - Zhu S
AD  - Department of Endocrinology, The Affiliated Wuxi People's Hospital of Nanjing 
      Medical University, Wuxi, China.
FAU - Yang, Cheng
AU  - Yang C
AD  - Department of Gastroenterology, The Affiliated Wuxi People's Hospital of Nanjing 
      Medical University, Wuxi, China.
LA  - eng
PT  - Journal Article
DEP - 20211130
PL  - Switzerland
TA  - Front Mol Biosci
JT  - Frontiers in molecular biosciences
JID - 101653173
PMC - PMC8670180
OTO - NOTNLM
OT  - PZP
OT  - biomarker
OT  - colorectal cancer
OT  - mass spectrum
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/12/18 06:00
MHDA- 2021/12/18 06:01
PMCR- 2021/01/01
CRDT- 2021/12/17 07:00
PHST- 2021/07/05 00:00 [received]
PHST- 2021/11/16 00:00 [accepted]
PHST- 2021/12/17 07:00 [entrez]
PHST- 2021/12/18 06:00 [pubmed]
PHST- 2021/12/18 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 736272 [pii]
AID - 10.3389/fmolb.2021.736272 [doi]
PST - epublish
SO  - Front Mol Biosci. 2021 Nov 30;8:736272. doi: 10.3389/fmolb.2021.736272. 
      eCollection 2021.