PMID- 34917873
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220429
IS  - 2514-1775 (Electronic)
IS  - 2514-1775 (Linking)
VI  - 5
IP  - 3
DP  - 2021
TI  - Indication and outcome of lupus anticoagulant and antiphospholipid antibodies 
      testing in routine clinical practice.
PG  - rkab093
LID - 10.1093/rap/rkab093 [doi]
LID - rkab093
AB  - OBJECTIVES: Lupus anticoagulans (LACs) and aPLs, both further summarized as aPL, 
      are frequently assessed in routine daily clinical practice in diagnostic workups 
      for suspected autoimmune diseases or to test for underlying risk factors in 
      patients with thrombosis or obstetric complications. The aim of this study was to 
      determine the prevalence of aPL positivity in patients with an indication for aPL 
      testing in routine clinical practice. METHODS: In this retrospective 
      single-centre study, indication for aPL testing, aPL test results and clinical 
      data were collected for patients tested between June 2015 and April 2018. 
      RESULTS: During the study period, 16 847 single aPL tests were performed in 2139 
      patients. In 212 patients one or more positive aPL test was found, confirmed in 
      43.9% with a second positive test. Indications for aPL testing were diagnostic 
      workup/follow-up of autoimmune diseases (33.6%), thrombosis (21.4%) and obstetric 
      complications (28%). Seventy-four patients (3.5% of all patients) fulfilled the 
      criteria of APS, of whom 51% were newly diagnosed. Second positive aPL titres and 
      titres of APS patients were significantly higher compared with positive aPL 
      titres at the first measurement (P < 0.05). Patients with indications of arterial 
      thrombosis and diagnostic workup/follow-up of autoimmune diseases had 
      significantly higher levels of aCL IgG and anti-beta2 glycoprotein I (beta2GPI) IgG 
      compared with patients with other indications. CONCLUSION: The prevalence of one 
      or more positive aPL test was 9.9% and APS was diagnosed in 3.5% of the patients. 
      Patients with arterial thrombosis had significantly higher anti-beta2GPI IgG and aCL 
      IgG, which should be confirmed in future studies.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the 
      British Society for Rheumatology.
FAU - Kempers, Eva K
AU  - Kempers EK
AUID- ORCID: 0000-0001-9458-8674
AD  - Department of Hematology.
FAU - Dalm, Virgil A S H
AU  - Dalm VASH
AD  - Department of Immunology.
AD  - Department of Internal Medicine, Division of Clinical Immunology.
FAU - van Rijn, Marie Josee E
AU  - van Rijn MJE
AD  - Department of Vascular Surgery.
FAU - Mulders, Annemarie G M G J
AU  - Mulders AGMGJ
AD  - Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center 
      Rotterdam, Rotterdam, The Netherlands.
FAU - Leebeek, Frank W G
AU  - Leebeek FWG
AD  - Department of Hematology.
FAU - de Maat, Moniek P M
AU  - de Maat MPM
AD  - Department of Hematology.
FAU - Jansen, A J Gerard
AU  - Jansen AJG
AUID- ORCID: 0000-0002-2612-1420
AD  - Department of Hematology.
LA  - eng
PT  - Journal Article
DEP - 20211127
PL  - England
TA  - Rheumatol Adv Pract
JT  - Rheumatology advances in practice
JID - 101736676
PMC - PMC8669994
OTO - NOTNLM
OT  - aPL
OT  - antiphospholipid syndrome
OT  - blood coagulation disorders
OT  - obstetric complications
OT  - thrombosis
EDAT- 2021/12/18 06:00
MHDA- 2021/12/18 06:01
PMCR- 2021/11/27
CRDT- 2021/12/17 07:03
PHST- 2021/06/16 00:00 [received]
PHST- 2021/11/17 00:00 [accepted]
PHST- 2021/12/17 07:03 [entrez]
PHST- 2021/12/18 06:00 [pubmed]
PHST- 2021/12/18 06:01 [medline]
PHST- 2021/11/27 00:00 [pmc-release]
AID - rkab093 [pii]
AID - 10.1093/rap/rkab093 [doi]
PST - epublish
SO  - Rheumatol Adv Pract. 2021 Nov 27;5(3):rkab093. doi: 10.1093/rap/rkab093. 
      eCollection 2021.