PMID- 34918133
OWN - NLM
STAT- MEDLINE
DCOM- 20220823
LR  - 20220823
IS  - 1439-7609 (Electronic)
IS  - 1439-7595 (Linking)
VI  - 32
IP  - 5
DP  - 2022 Aug 20
TI  - Rheumatologic manifestations in a cohort of patients with Vogt-Koyanagi-Harada 
      disease.
PG  - 994-998
LID - 10.1093/mr/roab061 [doi]
AB  - OBJECTIVES: Vogt-Koyanagi-Harada Disease (VKHD) is a systemic autoimmune disorder 
      characterized by granulomatous panuveitis. Inflammatory rheumatic diseases (IRDs) 
      are among the differential diagnosis of VKHD. However, current knowledge on the 
      rheumatological aspects of VKHD is still limited. We aimed to investigate the 
      prevalence of rheumatic conditions in VKHD patients. METHODS: VKHD patients were 
      included in the study and they were reviewed in terms of the presence of any 
      rheumatological manifestations. RESULTS: There were 18 patients with a female 
      preponderance (83.3%, female). Inflammatory type of peripheral joint pain (11%) 
      and sicca symptoms (33%) were the most common rheumatological findings. The 
      frequency of spondyloarthritis-related features such as inflammatory back pain 
      and HLA-B27 rate was not increased. None of the patients had radiographic 
      sacroiliitis. Anti-nuclear antibody was positive in high titres nearly in 30% of 
      the patients and three patients had antibodies against extractable nuclear 
      antigens. Nailfold capillaroscopy was abnormal in about one-third of the 
      patients. Pathergy test was negative in all cohorts. While angiotensin-converting 
      enzyme was elevated in nearly 20% of the patients, there were no abnormalities on 
      chest X-rays. CONCLUSION: VKHD shares some features with IRDs. The common 
      features were mostly suggestive of connective tissue disease rather than SpA or 
      rheumatoid arthritis.
CI  - (c) Japan College of Rheumatology 2021. Published by Oxford University Press. All 
      rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
FAU - Kocaer, Sinem Burcu
AU  - Kocaer SB
AUID- ORCID: 0000-0002-5481-0776
AD  - Department of Rheumatology, Dokuz Eylul University, Izmir, Turkey.
FAU - Kaya, Mahmut
AU  - Kaya M
AD  - Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey.
FAU - Yilmaz, Suzan Guven
AU  - Yilmaz SG
AD  - Department of Ophthalmology, Ege University, Izmir, Turkey.
FAU - Ayhan, Ziya
AU  - Ayhan Z
AD  - Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey.
FAU - Saatci, Ali Osman
AU  - Saatci AO
AD  - Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey.
FAU - Onen, Fatos
AU  - Onen F
AD  - Department of Rheumatology, Dokuz Eylul University, Izmir, Turkey.
FAU - Sari, Ismail
AU  - Sari I
AD  - Department of Rheumatology, Dokuz Eylul University, Izmir, Turkey.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
SB  - IM
MH  - *Arthritis, Rheumatoid
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - *Rheumatic Diseases/complications/diagnostic imaging/epidemiology
MH  - *Uveomeningoencephalitic Syndrome/complications/diagnosis/epidemiology
OTO - NOTNLM
OT  - Rheumatoid arthritis
OT  - Vogt-Koyanagi-Harada disease
OT  - spondyloarthritis
OT  - undifferentiated connective tissue diseases
OT  - vasculitis
EDAT- 2021/12/18 06:00
MHDA- 2022/08/24 06:00
CRDT- 2021/12/17 07:10
PHST- 2021/06/01 00:00 [received]
PHST- 2021/07/24 00:00 [revised]
PHST- 2021/08/05 00:00 [accepted]
PHST- 2021/12/18 06:00 [pubmed]
PHST- 2022/08/24 06:00 [medline]
PHST- 2021/12/17 07:10 [entrez]
AID - 6363771 [pii]
AID - 10.1093/mr/roab061 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2022 Aug 20;32(5):994-998. doi: 10.1093/mr/roab061.