PMID- 34920683
OWN - NLM
STAT- MEDLINE
DCOM- 20220317
LR  - 20220317
IS  - 2309-4990 (Electronic)
IS  - 1022-5536 (Linking)
VI  - 29
IP  - 3
DP  - 2021 Sep-Dec
TI  - Clinical outcome of Maggot Debridement Therapy followed by Negative Pressure 
      Wound Therapy for chronic hand wound with Multi-Drug Resistant Organism 
      infection: Two cases and review of the literature.
PG  - 23094990211067302
LID - 10.1177/23094990211067302 [doi]
AB  - The advancement in science and research has led to development of medical maggots 
      which feed exclusively on dead tissue. Medical maggots have three important 
      functions namely debridement, disinfection, and stimulation of wound healing. The 
      modern use of medical maggots now goes by the term "Maggot Debridement Therapy" 
      (MDT) for use in wound management. MDT is still used infrequently due to the 
      effectiveness of surgical debridement and antibiotics for treatment of wound 
      infection. Lately, there was emergence of Multi-Drug Resistant Organism (MDRO) 
      likely due to inappropriate antibiotics usage. Maggot secretions have been shown 
      to be effective in inhibiting some MDRO, for example, Methicillin-resistant 
      Staphylococcus aureus, thus making MDT an attractive option for wounds with MDRO. 
      We report two patients with multiple medical comorbidities, diagnosed with 
      serious MDRO Diabetic Hand Infections treated with three cycles of MDT followed 
      by Negative Pressure Wound Therapy.
FAU - Phang, Zi Hao
AU  - Phang ZH
AUID- ORCID: 0000-0001-8703-1069
AD  - National Orthopaedic Centre of Excellence for Research and Learning (NOCERAL), 
      Department of Orthopaedic Surgery, Faculty of Medicine, 65300University Malaya, 
      Kuala Lumpur, Malaysia.
FAU - Khoo, Saw Sian
AU  - Khoo SS
AD  - National Orthopaedic Centre of Excellence for Research and Learning (NOCERAL), 
      Department of Orthopaedic Surgery, Faculty of Medicine, 65300University Malaya, 
      Kuala Lumpur, Malaysia.
FAU - Gunasagaran, Jayaletchumi
AU  - Gunasagaran J
AUID- ORCID: 0000-0001-5398-6545
AD  - National Orthopaedic Centre of Excellence for Research and Learning (NOCERAL), 
      Department of Orthopaedic Surgery, Faculty of Medicine, 65300University Malaya, 
      Kuala Lumpur, Malaysia.
FAU - Tunku Ahmad, Tunku Sara
AU  - Tunku Ahmad TS
AD  - National Orthopaedic Centre of Excellence for Research and Learning (NOCERAL), 
      Department of Orthopaedic Surgery, Faculty of Medicine, 65300University Malaya, 
      Kuala Lumpur, Malaysia.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Orthop Surg (Hong Kong)
JT  - Journal of orthopaedic surgery (Hong Kong)
JID - 9440382
SB  - IM
MH  - Animals
MH  - Debridement
MH  - *Hand Injuries
MH  - Humans
MH  - Larva
MH  - *Methicillin-Resistant Staphylococcus aureus
MH  - *Negative-Pressure Wound Therapy
OTO - NOTNLM
OT  - antibiotic resistance
OT  - dressing
OT  - hand
OT  - infection
OT  - maggot
OT  - wound
EDAT- 2021/12/19 06:00
MHDA- 2022/03/18 06:00
CRDT- 2021/12/18 05:20
PHST- 2021/12/18 05:20 [entrez]
PHST- 2021/12/19 06:00 [pubmed]
PHST- 2022/03/18 06:00 [medline]
AID - 10.1177/23094990211067302 [doi]
PST - ppublish
SO  - J Orthop Surg (Hong Kong). 2021 Sep-Dec;29(3):23094990211067302. doi: 
      10.1177/23094990211067302.